Paramagnetic Ultrasmall Gadolinium Oxide Nanoparticles as Advanced T1 MRI Contrast Agent: Account for Large Longitudinal Relaxivity, Optimal Particle Diameter, and In Vivo T1 MR Images

ACS Nano ◽  
2009 ◽  
Vol 3 (11) ◽  
pp. 3663-3669 ◽  
Author(s):  
Ja Young Park ◽  
Myung Ju Baek ◽  
Eun Sook Choi ◽  
Seungtae Woo ◽  
Joo Hyun Kim ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Particle Diameter ◽  
Gadolinium Oxide ◽  
Mri Contrast Agent ◽  
Oxide Nanoparticles ◽  
Mr Images ◽  
Mri Contrast ◽  
Longitudinal Relaxivity ◽  
Gadolinium Oxide Nanoparticles

Ligand-size dependent water proton relaxivities in ultrasmall gadolinium oxide nanoparticles and in vivo T1 MR images in a 1.5 T MR field

2014 ◽  
Vol 16 (37) ◽  
pp. 19866-19873 ◽  
Author(s):  
Cho Rong Kim ◽  
Jong Su Baeck ◽  
Yongmin Chang ◽  
Ji Eun Bae ◽  
Kwon Seok Chae ◽  
...  
Keyword(s):  
Gadolinium Oxide ◽  
Water Proton ◽  
Oxide Nanoparticles ◽  
Mr Images ◽  
Size Dependent ◽  
Gadolinium Oxide Nanoparticles

Ligand-size dependent r1 and r2 values of Gd2O3 nanoparticles and in vivo T1 MR images were obtained.

Chitosan Oligosaccharide Lactate-Coated Ultrasmall Gadolinium Oxide Nanoparticles: Synthesis, In Vitro Cytotoxicity, and Relaxometric Properties

2021 ◽  
Vol 21 (8) ◽  
pp. 4145-4150
Author(s):  
Mohammad Yaseen Ahmad ◽  
Md. Wasi Ahmad ◽  
Huan Yue ◽  
Son Long Ho ◽  
Hyunsil Cha ◽  
...  
Keyword(s):  
Gadolinium Oxide ◽  
Mri Contrast Agents ◽  
Proton Spin ◽  
Mri Contrast Agent ◽  
Water Proton ◽  
Oxide Nanoparticles ◽  
Chitosan Oligosaccharide ◽  
Mri Contrast ◽  
Gadolinium Oxide Nanoparticles

In this study, hydrophilic and biocompatible chitosan oligosaccharide lactate (COL)-coated ultra-small gadolinium oxide nanoparticles (NPs) were synthesized through a one-pot polyol method and characterized by various experimental techniques. The In Vitro cellular cytotoxicity assay indicated that the COL-coated gadolinium oxide NPs were non-toxic up to 500 μM Gd. In addition, their water proton spin relaxivities (i.e., r1 and r2) were estimated to be 13.0 and 27.0 s−1mM−1, respectively, which are higher than those of commercial magnetic resonance imaging (MRI) contrast agents. The application potential of the solution sample as a T1 MRI contrast agent was demonstrated In Vitro by measuring map images in which dose-dependent contrast enhancements were observed.

scholarly journals Biocompatibility of Bacterial Magnetosomes as MRI Contrast Agent: A Long-Term In Vivo Follow-Up Study

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1235
Author(s):  
Xiaohui Nan ◽  
Wenjia Lai ◽  
Dan Li ◽  
Jiesheng Tian ◽  
Zhiyuan Hu ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Magnetic Domain ◽  
Bilayer Membrane ◽  
The Body ◽  
Mri Contrast Agent ◽  
Mri Imaging ◽  
Mri Contrast

Derived from magnetotactic bacteria (MTB), magnetosomes consist of magnetite crystals enclosed within a lipid bilayer membrane and are known to possess advantages over artificially synthesized nanoparticles because of the narrow size distribution, uniform morphology, high purity and crystallinity, single magnetic domain, good biocompatibility, and easy surface modification. These unique properties have increasingly attracted researchers to apply bacterial magnetosomes (BMs) in the fields of biology and medicine as MRI imaging contrast agents. Due to the concern of biosafety, a long-term follow-up of the distribution and clearance of BMs after entering the body is necessary. In this study, we tracked changes of BMs in major organs of mice up to 135 days after intravenous injection using a combination of several techniques. We not only confirmed the liver as the well-known targeted organs of BMs, but also found that BMs accumulated in the spleen. Besides, two major elimination paths, as well as the approximate length of time for BMs to be cleared from the mice, were revealed. Together, the results not only confirm that BMs have high biocompatibility, but also provide a long-term in-vivo assessment which may further help to forward the clinical applications of BMs as an MRI contrast agent.

scholarly journals Study on Establishing Reference Safe Concentrations of MRI Contrast Agents for Optimized Images: Paramagnetic Gd-DTPA-BMEA and Superparamagnetic Ferucarbotran

2021 ◽  
Vol 11 (3) ◽  
pp. 1165
Author(s):  
Wen-Tien Hsiao ◽  
Yi-Hong Chou ◽  
Jhong-Wei Tu ◽  
Ai-Yih Wang ◽  
Lu-Han Lai
Keyword(s):  
Contrast Agent ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast Agent ◽  
In Vitro Experiments ◽  
Mri Contrast ◽  
In Vivo Experiments ◽  
Contrast Agent Injection

The purpose of this study is to establish the minimal injection doses of magnetic resonance imaging (MRI) contrast agents that can achieve optimized images while improving the safety of injectable MRI drugs. Gadolinium-diethylenetriamine penta-acetic acid (Gd-DTPA) and ferucarbotran, commonly used in clinical practice, were selected and evaluated with in vitro and in vivo experiments. MRI was acquired using T1-weighted (T1W) and T2-weighted (T2W) sequences, and the results were quantitatively analyzed. For in vitro experiments, results showed that T1W and T2W images were optimal when Gd-DTPA-bisamide (2-oxoethyl) (Gd-DTPA-BMEA) and ferucarbotran were diluted to a volume percentage of 0.6% and 0.05%; all comparisons were significant differences in grayscale statistics using one-way analysis of variance (ANOVA). For in vivo experiments, the contrast agent with optimal concentration percentages determined from in vitro experiments were injected into mice with an injection volume of 100 μL, and the images of brain, heart, liver, and mesentery before and after injection were compared. The statistical results showed that the p values of both T1W and T2W were less than 0.001, which were statistically significant. Under safety considerations for MRI contrast agent injection, optimized MRI images could still be obtained after reducing the injection concentration, which can provide a reference for the safety concentrations of MRI contrast agent injection in the future.

Ultra-small gadolinium oxide nanoparticles to image brain cancer cells in vivo with MRI

2010 ◽  
pp. n/a-n/a ◽  
Author(s):  
Luc Faucher ◽  
Andrée-Anne Guay-Bégin ◽  
Jean Lagueux ◽  
Marie-France Côté ◽  
Éric Petitclerc ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Brain Cancer ◽  
Gadolinium Oxide ◽  
Oxide Nanoparticles ◽  
Gadolinium Oxide Nanoparticles

Hybrid Gadolinium Oxide Nanoparticles:  Multimodal Contrast Agents for in Vivo Imaging

2007 ◽  
Vol 129 (16) ◽  
pp. 5076-5084 ◽  
Author(s):  
Jean-Luc Bridot ◽  
Anne-Charlotte Faure ◽  
Sophie Laurent ◽  
Charlotte Rivière ◽  
Claire Billotey ◽  
...  
Keyword(s):  
Contrast Agents ◽  
In Vivo Imaging ◽  
Gadolinium Oxide ◽  
Oxide Nanoparticles ◽  
Gadolinium Oxide Nanoparticles
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