scholarly journals A Quantitative Study on the Photothermal Effect of Immuno Gold Nanocages Targeted to Breast Cancer Cells

ACS Nano ◽  
2008 ◽  
Vol 2 (8) ◽  
pp. 1645-1652 ◽  
Author(s):  
Leslie Au ◽  
Desheng Zheng ◽  
Fei Zhou ◽  
Zhi-Yuan Li ◽  
Xingde Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Quantitative Study ◽  
Breast Cancer Cells ◽  
Photothermal Effect ◽  
Gold Nanocages

scholarly journals Comparative effect of thermo/pH-responsive polymer-coated gold nanocages and hollow nanostars on chemo-photothermal therapy of breast cancer cells

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Asrin Pakravan ◽  
Mehdi Azizi ◽  
Fariborz Rahimi ◽  
Farhad Bani ◽  
Farideh Mahmoudzadeh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Mtt Assay ◽  
Photothermal Therapy ◽  
Breast Cancer Cells ◽  
Covalent Attachment ◽  
Mcf7 Cells ◽  
Dapi Staining ◽  
Hemolysis Assay ◽  
Gold Nanocages

Abstract Background Combination chemo-photothermal therapy appears to be one of the next generations of cancer treatment. In this study hollow gold nanostars (HGNSs) and gold nanocages (GNCs) were synthesized and stabilized with thermo-pH-sensitive thiol-end capped ABC triblock copolymer poly(acrylic acid)-b-poly(N isopropylacrylamide)-b-poly (e-caprolactone)-SH; PAA-b-PNIPAAm-b-PCL-SH (GNSs@Pol). Doxorubicin (Dox) was conjugated to the GNSs@Pol nanostructures via ionic interaction, covalent attachment and hydrogen bonding (GNSs@Dox-Pol). The physicochemical characteristics of prepared GNSs@Pol and GNSs were assessed using dynamic light scattering (DLS), transmission electron microscopy (TEM) and zeta potential techniques. Cytocompatibility of the GNSs@Pol was studied by hemolysis assay and MTT assay. The chemo-photothermal therapy (PTT) potential of GNSs@Dox-Pol was compared on MCF7 cells using MTT assay, cell cycle, DAPI staining and Annexin-V apoptosis assay techniques. Results Cell internalization results showed an almost complete uptake of GNSs@Pol by MCF-7 cells in the first 3 h of treatment. The heat generation measurement results showed that both of GNSs have a potential for light to heat conversion (∆T = 23–27 ºC) and HGNSs demonstrated better efficiency than GNCs after 10-min exposure to NIR irradiation. Following chemo-photothermal treatment, the highest cell mortality (90%) and apoptotic effects (97% apoptosis) were observed in HGNSs@Dox-Pol received laser irradiation treatment group. Conclusions This work highlights the potential application of designed GNSs@Dox-Pol in a combinational chemo-PTT to treat breast cancer cells. Graphic abstract

Quantitative Study of the Interaction of Multivalent Ligand-Modified Nanoparticles with Breast Cancer Cells with Tunable Receptor Density

ACS Nano ◽  
2020 ◽  
Vol 14 (1) ◽  
pp. 372-383 ◽  
Author(s):  
Jing Wang ◽  
Junseon Min ◽  
Seyed Ali Eghtesadi ◽  
Ravi S. Kane ◽  
Ashutosh Chilkoti
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Quantitative Study ◽  
Breast Cancer Cells ◽  
Receptor Density

scholarly journals Does conjugation strategy matter? Cetuximab-conjugated gold nanocages for targeting triple-negative breast cancer cells

2019 ◽  
Vol 1 (9) ◽  
pp. 3626-3638 ◽  
Author(s):  
S. Avvakumova ◽  
L. Pandolfi ◽  
E. Soprano ◽  
L. Moretto ◽  
M. Bellini ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Active Targeting ◽  
Gold Nanocages

The efficient targeting of cancer cells depends on the success of obtaining the active targeting of overexpressed receptors.

scholarly journals Advanced microscopic evaluation of parallel type I and type II cell deaths induced by multi-functionalized gold nanocages in breast cancer

2019 ◽  
Vol 1 (3) ◽  
pp. 989-1001 ◽  
Author(s):  
Sreejith Raveendran ◽  
Anindito Sen ◽  
Hiromi Ito-Tanaka ◽  
Kazunori Kato ◽  
Toru Maekawa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Type I ◽  
Type Ii ◽  
Microscopic Evaluation ◽  
Type Ii Cell ◽  
Gold Nanocages ◽  
Parallel Type

This work evaluates the potential of type I and type II cell deaths in parallel killing of breast cancer cells to mitigate the induced chemoresistance caused.

scholarly journals Near-Infrared Light-Triggered Thermo-responsive Poly(N-Isopropylacrylamide)-Pyrrole Nanocomposites for Chemo-photothermal Cancer Therapy

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Ha Hee Shin ◽  
Hyung Woo Choi ◽  
Jae Hyun Lim ◽  
Ji Woon Kim ◽  
Bong Geun Chung
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Therapeutic Efficacy ◽  
Breast Cancer Cells ◽  
Near Infrared ◽  
Solution Temperature ◽  
Photothermal Effect ◽  
Synthetic Process ◽  
Nir Laser

AbstractThe combination therapy based on multifunctional nanocomposites has been considered as a promising approach to improve cancer therapeutic efficacy. Herein, we report targeted multi-functional poly(N-isopropylacrylamide) (PNIPAM)-based nanocomposites for synergistic chemo-photothermal therapy toward breast cancer cells. To increase the transition temperature, acrylic acid (AAc) was added in synthetic process of PNIPAM, showing that the intrinsic lower critical solution temperature was changed to 42 °C . To generate the photothermal effect under near-infrared (NIR) laser irradiation (808 nm), polypyrrole (ppy) nanoparticles were uniformly decorated in PNIPAM-AAc. Folic acid (FA), as a cancer targeting ligand, was successfully conjugated on the surplus carboxyl groups in PNIPAM network. The drug release of PNIPAM-ppy-FA nanocomposites was efficiently triggered in response to the temperature change by NIR laser irradiation. We also confirmed that PNIPAM-ppy-FA was internalized to MDA-MB-231 breast cancer cells by folate-receptor-mediated endocytosis and significantly enhanced cancer therapeutic efficacy with combination treatment of chemo-photothermal effects. Therefore, our work encourages further exploration of multi-functional nanocarrier agents for synergistic therapeutic approaches to different types of cancer cells.

The proliferation of breast cancer cells are inhibited by the human intrabody targeting cyclinD1

2010 ◽  
Vol 34 (8) ◽  
pp. S49-S49
Author(s):  
Lei Wang ◽  
Xun Zhou ◽  
Lihong Zhou ◽  
Yong Chen ◽  
Xun Zhu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells
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