pH-Responsive Poly(d,l-lactic-co-glycolic acid) Nanoparticles with Rapid Antigen Release Behavior Promote Immune Response

ACS Nano ◽  
2015 ◽  
Vol 9 (5) ◽  
pp. 4925-4938 ◽  
Author(s):  
Qi Liu ◽  
Xiaoming Chen ◽  
Jilei Jia ◽  
Weifeng Zhang ◽  
Tingyuan Yang ◽  
...  
Keyword(s):  
Immune Response ◽  
Glycolic Acid ◽  
Release Behavior ◽  
Ph Responsive ◽  
Antigen Release

Design of pH-responsive poly(D, L-lactic-co-glycolic acid) nanoparticles to promote immune response

2017 ◽  
Vol 259 ◽  
pp. e81
Author(s):  
Lianyan Wang ◽  
Qi Liu ◽  
Jilei Jia ◽  
Tingyuan Yang ◽  
Guanghui Ma
Keyword(s):  
Immune Response ◽  
Glycolic Acid ◽  
Ph Responsive

Injectable Polypeptide Hydrogel Depot System for Assessment of the Immune Response–Inducing Efficacy of Sustained Antigen Release Alone

2019 ◽  
Vol 19 (10) ◽  
pp. 1900167 ◽  
Author(s):  
Daisuke Asai ◽  
Tadashi Fukuda ◽  
Kazunori Morokuma ◽  
Daiki Funamoto ◽  
Yuko Yamaguchi ◽  
...  
Keyword(s):  
Immune Response ◽  
Antigen Release

scholarly journals Preparation and Swelling Behaviors of High-Strength Hemicellulose-g-Polydopamine Composite Hydrogels

Materials ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 186
Author(s):  
Jiayan Ge ◽  
Kaiqi Gu ◽  
Kewen Sun ◽  
Xinyue Wang ◽  
Shuangquan Yao ◽  
...  
Keyword(s):  
Water Retention ◽  
High Strength ◽  
Release Behavior ◽  
Ph Responsive ◽  
Composite Hydrogels ◽  
Hydrogel Network ◽  
Microsphere Size ◽  
Chemical Cross Linking ◽  
Swelling Behaviors ◽  
Good Water Retention

Hemicellulose-based composite hydrogels were successfully prepared by adding polydopamine (PDA) microspheres as reinforcing agents. The effects of PDA microsphere size, dosage, and nitrogen content in hydrogel on the mechanical and rheological properties was studied. The compressive strength of hydrogel was increased from 0.11 to 0.30 MPa. The storage modulus G’ was increased from 7.9 to 22.0 KPa. The gaps in the hemicellulose network are filled with PDA microspheres. There is also chemical cross-linking between them. These gaps increased the density of the hydrogel network structure. It also has good water retention and pH sensitivity. The maximum cumulative release rate of methylene blue was 62.82%. The results showed that the release behavior of hydrogel was pH-responsive, which was beneficial to realizing targeted and controlling drug release.

pH-responsive Astragalus polysaccharides-loaded poly(lactic-co-glycolic acid) nanoparticles and their in vitro immunogenicity

2019 ◽  
Vol 125 ◽  
pp. 865-875 ◽  
Author(s):  
Shuwen Xu ◽  
Adelijiang Wusiman ◽  
Zhenguang Liu ◽  
Pengfei Gu ◽  
Haiyu Ni ◽  
...  
Keyword(s):  
Glycolic Acid ◽  
Ph Responsive ◽  
Astragalus Polysaccharides

scholarly journals ENZYMATICALLY SYNTHESIZED pH-RESPONSIVE IPN FOR IN-SITU RELEASE OF PANTOPRAZOLE SODIUM

2019 ◽  
pp. 98-103
Author(s):  
Saruchi Sharma ◽  
VANEET KUMAR
Keyword(s):  
Drug Release ◽  
Polymer Network ◽  
Lateral Diffusion ◽  
Ph Sensitive ◽  
Interpenetrating Polymer Network ◽  
Release Behavior ◽  
Ph Responsive ◽  
Gum Tragacanth ◽  
Swelling Capacity

Objective: This study involves the synthesis of Gum tragacanth (gt) based interpenetrating polymer network (ipn) and its utilization for sustained release of anti-ulcerative drug i.e. pantoprazole sodium. Methods: IPN was synthesized from Gum tragacanth, polyacrylic acid (gt-cl-paa) hydrogel. gt-cl-paa was kept in distilled water. Further, acryamide (aam) and methylmethacrylate (mma) was added and then kept for overnight. Later on, lipase and glutaraldehyde were added. Homopolymers and the unreacted monomers were removed using acetone. Synthesized IPN was dried at 50 °C for further study. Synthesized ipn was swelled in water and the drug was added to it. The drug was entrapped in the pores of the synthesized ipn and then drug release behavior was studied using uv-vis spectrophotometer. Results: Gt, paa and mma based crosslinked IPN were synthesized using lipase-glutaraldehyde as initiator-crosslinker system. The synthesized IPN was pH sensitive and possessed the desired swelling capacity required for the controlled and systematic liberation of pantoprazole sodium at 37 °C. The kinetic of drug release was studied and found that lateral diffusion (DL) of drug was higher as compared to the initial diffusion (DI). The prepared IPN can be used as prospective carrier for prolonged drug delivery. Conclusion: A novel pH sensitive and colon targeted IPN was synthesized. It acts as an effective device for the controlled release of drug pantoprazole sodium.

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