Smart Human Serum Albumin-Indocyanine Green Nanoparticles Generated by Programmed Assembly for Dual-Modal Imaging-Guided Cancer Synergistic Phototherapy

ACS Nano ◽  
2014 ◽  
Vol 8 (12) ◽  
pp. 12310-12322 ◽  
Author(s):  
Zonghai Sheng ◽  
Dehong Hu ◽  
Mingbin Zheng ◽  
Pengfei Zhao ◽  
Huilong Liu ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Indocyanine Green ◽  
Human Serum ◽  
Programmed Assembly

Detection of the Communication Site by Indocyanine Green Adsorbed to Human Serum Albumin Fluorescence During Surgery for a Pleuroperitoneal Communication

2021 ◽  
Author(s):  
Daisuke Kimura ◽  
Ikuo Fukuda ◽  
Takeshi Fujita ◽  
Reiichi Murakami ◽  
Norio Nakamura ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Indocyanine Green ◽  
Human Serum ◽  
Near Infrared ◽  
Thoracoscopic Surgery ◽  
Good Method ◽  
Pleuroperitoneal Communication ◽  
Fluorescence Images ◽  
One Year

Abstract A pleuroperitoneal communication is a serious complication for patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Video-assisted thoracoscopic surgery is performed using indocyanine green adsorbed to human serum albumin fluorescence to identify the communication because human serum albumin reinforces fluorescence images. A patient diagnosed with a pleuroperitoneal communication was referred to our department and underwent surgery. To detect the communication, a dialysate mixture that contained indocyanine green and human serum albumin was injected from the CAPD catheter. Real-time fluorescence images were able to clearly show a bleb-like lesion with a near-infrared spectroscopy camera, and the site was repaired. The patient had no recurrence at one-year follow-up. This method might be good method for pleuroperitoneal communication surgery.

Benefit of technetium-99mgalactosyl human serum albumin scintigraphy instead of indocyanine green test in patients scheduled for hepatectomy

2014 ◽  
Vol 44 (10) ◽  
pp. E118-E128 ◽  
Author(s):  
Yasuo Ohkura ◽  
Shugo Mizuno ◽  
Masashi Kishiwada ◽  
Takashi Hamada ◽  
Masanobu Usui ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Indocyanine Green ◽  
Human Serum ◽  
Indocyanine Green Test

scholarly journals Human Serum Albumin Decorated Indocyanine Green Improves Fluorescence-Guided Resection of Residual Lesions of Breast Cancer in Mice

2021 ◽  
Vol 11 ◽  
Author(s):  
Zun Wang ◽  
Min Chen ◽  
Jing-Jing Liu ◽  
Rong-He Chen ◽  
Qian Yu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Indocyanine Green ◽  
Human Serum ◽  
Real Time ◽  
Mice Model ◽  
Cancer Tissues ◽  
Residual Lesions

ObjectiveAchieving negative resection margin is critical but challenging in breast-conserving surgery. Fluorescence-guided surgery allows the surgeon to visualize the tumor bed in real-time and to facilitate complete resection. We envisioned that intraoperative real-time fluorescence imaging with a human serum albumin decorated indocyanine green probe could enable complete surgical removal of breast cancer in a mouse model.MethodsWe prepared the probe by conjugating indocyanine green (ICG) with human serum albumin (HSA). In vitro uptake of the HSA-ICG probe was compared between human breast cancer cell line MDA-MB-231 and normal breast epithelial cell line MCF 10A. In vivo probe selectivity for tumors was examined in nude mice bearing MDA-MB-231-luc xenografts and the FVB/N-Tg (MMTV-PyMT) 634Mul/J mice model with spontaneous breast cancer. A positive-margin resection mice model bearing MDA-MB-231-luc xenograft was established and the performance of the probe in assisting surgical resection of residual lesions was examined.ResultsA significantly stronger fluorescence intensity was detected in MDA-MB-231 cells than MCF 10A cells incubated with HSA-ICG. In vivo fluorescence imaging showed that HSA-ICG had an obvious accumulation at tumor site at 24 h with tumor-to-normal tissue ratio of 8.19 ± 1.30. The same was true in the transgenic mice model. The fluorescence intensity of cancer tissues was higher than that of non-cancer tissues (58.53 ± 18.15 vs 32.88 ± 11.34). During the surgical scenarios, the residual tumors on the surgical bed were invisible with the naked eye, but were detected and resected with negative margin under HSA-ICG guidance in all the mice (8/8). Recurrence rate among mice that underwent resection with HSA-ICG (0/8) was significantly lower than the rates among mice with ICG (4/8), as well as the control group under white light (7/7).ConclusionsThis study suggests that real-time in vivo visualization of breast cancer with an HSA-ICG fluorescent probe facilitates complete surgical resection of breast cancer in a mouse xenograft model.

Human serum albumin (HSA) coated liposomal indocyanine green for in vivo tumor imaging

RSC Advances ◽  
2016 ◽  
Vol 6 (18) ◽  
pp. 15220-15225 ◽  
Author(s):  
Siqin Chen ◽  
Gongjie Yu ◽  
Bo Zhang ◽  
Yinsong Wang ◽  
Ning Zhang ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Indocyanine Green ◽  
Human Serum ◽  
Near Infrared ◽  
Tumor Imaging ◽  
Fluorescent Nanoprobe

In this study, a near-infrared (NIR) fluorescent nanoprobe based on indocyanine green (ICG) was synthesized.

scholarly journals Indocyanine green can stand alone in detecting sentinel lymph nodes in cervical cancer

2018 ◽  
Vol 46 (12) ◽  
pp. 4885-4897 ◽  
Author(s):  
Qurat Ulain ◽  
Lu Han ◽  
Qian Wu ◽  
Lanbo Zhao ◽  
Qi Wang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Lymph Nodes ◽  
Indocyanine Green ◽  
Human Serum ◽  
Detection Rate ◽  
Sentinel Lymph Nodes ◽  
Detection Rates ◽  
Pubmed Database

Objectives The effectiveness of indocyanine green (ICG) dye for detecting sentinel lymph nodes (SLNs) in cervical cancer compared with other tracers is unknown. This study aimed to assess the validity of ICG dye in detecting SLNs in cervical cancer preoperatively. Methods We performed a literature search for identifying eligible articles from PubMed database using the search terms “cervical cancer”, “sentinel lymph node”, “indocyanine green”, “blue dyes”, “human serum albumin”, and “technetium-99 radiocolloid”. We performed a meta-analysis. Comparison of the overall, bilateral, and unilateral detection rates of the different tracers was the primary goal. Comparison of the false-negative rate among the tracers was the secondary goal. Results Only eight retrospective studies including 661 patients were included. ICG versus combinations of three other tracers showed significantly higher bilateral and unilateral detection rates, but no difference in the overall rate of detecting SLNs. ICG had a higher bilateral detection rate than blue dye and technetium-99. Absorbing human serum albumin into ICG as a lymphatic tracer did not show a difference in detection rate compared with ICG alone. Conclusions ICG is superior and better than other tracers, and absorbing human serum albumin as a lymphatic tracer is not required in patients with cervical cancer.

Investigating the role of human serum albumin protein pocket on the excited state dynamics of indocyanine green using shaped femtosecond laser pulses

2015 ◽  
Vol 17 (8) ◽  
pp. 5872-5877 ◽  
Author(s):  
Muath Nairat ◽  
Arkaprabha Konar ◽  
Marie Kaniecki ◽  
Vadim V. Lozovoy ◽  
Marcos Dantus
Keyword(s):  
Excited State ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Indocyanine Green ◽  
Human Serum ◽  
Laser Pulses ◽  
Femtosecond Laser Pulses ◽  
Vibrational Motion ◽  
Protein Pocket

When indocyanine green (ICG) is confined inside the pocket of human serum albumin its triplet state formation is mitigated and coherent vibrational motion becomes more observable.

Spectrometric study on the interaction of indocyanine green with human serum albumin

2016 ◽  
Vol 32 (3) ◽  
pp. 343-347 ◽  
Author(s):  
Xiaodong Li ◽  
Yu Fu ◽  
Lina Ma ◽  
Zhenxin Wang ◽  
Huimao Zhang
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Indocyanine Green ◽  
Human Serum ◽  
Spectrometric Study

Endoscopic sentinel lymph node biopsy using indocyanine green-neomannosyl human serum albumin

2017 ◽  
Vol 128 (4) ◽  
pp. E135-E140 ◽  
Author(s):  
Young Min Park ◽  
Yu Hua Quan ◽  
Ki Hyeok Kwon ◽  
Jae-Gu Cho ◽  
Jeong-Soo Woo ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Indocyanine Green ◽  
Human Serum ◽  
Lymph Node Biopsy ◽  
Node Biopsy
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