scholarly journals Biological Functionalization of Drug Delivery Carriers To Bypass Size Restrictions of Receptor-Mediated Endocytosis Independently from Receptor Targeting

ACS Nano ◽  
2013 ◽  
Vol 7 (12) ◽  
pp. 10597-10611 ◽  
Author(s):  
Maria Ansar ◽  
Daniel Serrano ◽  
Iason Papademetriou ◽  
Tridib Kumar Bhowmick ◽  
Silvia Muro
Keyword(s):  
Drug Delivery ◽  
Receptor Targeting ◽  
Receptor Mediated Endocytosis

Receptor-mediated endocytosis and targeted drug delivery

Hepatology ◽  
1985 ◽  
Vol 5 (5) ◽  
pp. 899-901 ◽  
Author(s):  
Robert J. Fallon ◽  
Alan L. Schwartz
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Receptor Mediated Endocytosis ◽  
Targeted Drug

Folate-conjugated nanodiamond for tumor-targeted drug delivery

RSC Advances ◽  
2015 ◽  
Vol 5 (101) ◽  
pp. 82711-82716 ◽  
Author(s):  
Yu Dong ◽  
Ruixia Cao ◽  
Yingqi Li ◽  
Zhiqin Wang ◽  
Lin Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Cells ◽  
Targeted Drug Delivery ◽  
Normal Cells ◽  
Folate Receptors ◽  
Receptor Mediated Endocytosis ◽  
Targeted Drug

Relying on the role of folate and folate receptors, NPFD nanoparticles tend to selectively discriminate tumor cells from normal cells and enter the cells by clathrin-dependent and receptor-mediated endocytosis.

scholarly journals Poroelastic Attributes: A Real-time Determinant Membrane Nanorheology for Receptor Dependent Endocytosis of Targeted Gold Nanoparticles

2021 ◽  
Author(s):  
Tanmay Abhay Kulkarni ◽  
Debabrata Mukhopadhyay ◽  
Santanu Bhattacharya
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Shear Stress ◽  
Diffusion Coefficient ◽  
Cell Membrane ◽  
Pore Size ◽  
Surface Engineering ◽  
Diffusion Constant ◽  
Uptake Mechanism ◽  
Receptor Mediated Endocytosis

Abstract BackgroundEfficacy of targeted drug delivery using nanoparticles relies on several factors including the uptake mechanisms such as phagocytosis, macropinocytosis, micropinocytosis and receptor mediated endocytosis. These mechanisms have been studied with respect to the alteration in signaling mechanisms, cellular morphology, and linear nanomechanical properties (NMPs). Commonly employed classical contact mechanics models to address cellular NMPs fail to address mesh like structure consisting of bilayer lipids and proteins of cell membrane. To overcome this technical challenge, we employed poroelastic model which accounts for the biphasic nature of cells including their porous behavior exhibiting both solid like (fluid storage) and liquid like (fluid dissipate) behavior ResultsIn this study, we employed atomic force microscopy to monitor the influence of surface engineering of gold nanoparticles (GNPs) to the alteration of nonlinear NMPs such as drained Poisson’s ratio, effective shear stress, diffusion constant and pore dimensions of cell membranes during their uptake. Herein, we used pancreatic cancer (PDAC) cell lines including Panc1, AsPC-1 and endothelial cell HUVECs to understand the receptor-dependent and -independent endocytosis of two different GNPs derived using plectin-1 targeting peptide (PTP-GNP) and corresponding scrambled peptide (sPEP-GNP). Compared to untreated cells, in case of receptor dependent endocytosis of PTP-GNPs diffusion coefficient altered ~1264-fold and ~1530-fold and pore size altered ~320-fold and ~260-fold in Panc1 and AsPC-1 cells respectively. Whereas for receptor independent mechanisms, we observed modest alteration in diffusion coefficient and pore size, in these cells compared to untreated cells. Effective shear stress corresponding to 7.38±0.15 kPa and 20.49±0.39 kPa in PTP-GNP treatment in Panc1 and AsPC-1, respectively was significantly more than that for sPEP-GNP. These results demonstrate that with temporal recruitment of plectin-1 during receptor mediated endocytosis affects the poroelastic attributes of the membrane. ConclusionThis study confirms that nonlinear NMPs of cell membrane are directly associated with the uptake mechanism of nanoparticles and can provide promising insights of the nature of endocytosis mechanism involved for organ specific drug delivery using nanoparticles. Hence, nanomechanical analysis of cell membrane es using this noninvasive, label-free and live-cell analytical tool can therefore be instrumental to evaluate therapeutic benefit of nanoformulations.

scholarly journals Correction: Biocompatible graphene oxide as a folate receptor-targeting drug delivery system for the controlled release of anti-cancer drugs

RSC Advances ◽  
2015 ◽  
Vol 5 (22) ◽  
pp. 17041-17041 ◽  
Author(s):  
Xubo Zhao ◽  
Peng Liu
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Folate Receptor ◽  
Cancer Drugs ◽  
Receptor Targeting ◽  
Anti Cancer ◽  
Folate Receptor Targeting

Correction for ‘Biocompatible graphene oxide as a folate receptor-targeting drug delivery system for the controlled release of anti-cancer drugs’ by Xubo Zhao et al., RSC Adv., 2014, 4, 24232–24239.

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