scholarly journals In Vivo Tumor Targeting and Image-Guided Drug Delivery with Antibody-Conjugated, Radiolabeled Mesoporous Silica Nanoparticles

ACS Nano ◽  
2013 ◽  
Vol 7 (10) ◽  
pp. 9027-9039 ◽  
Author(s):  
Feng Chen ◽  
Hao Hong ◽  
Yin Zhang ◽  
Hector F. Valdovinos ◽  
Sixiang Shi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Tumor Targeting ◽  
Mesoporous Silica Nanoparticles ◽  
Image Guided ◽  
Image Guided Drug Delivery

scholarly journals Hollow mesoporous silica nanoparticles for tumor vasculature targeting and PET image-guided drug delivery

Nanomedicine ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. 1233-1246 ◽  
Author(s):  
Rubel Chakravarty ◽  
Shreya Goel ◽  
Hao Hong ◽  
Feng Chen ◽  
Hector F Valdovinos ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Tumor Vasculature ◽  
Image Guided ◽  
Image Guided Drug Delivery ◽  
Hollow Mesoporous Silica

Functional Mesoporous Silica Nanoparticles for Photothermal-Controlled Drug Delivery In Vivo

2012 ◽  
Vol 124 (33) ◽  
pp. 8498-8502 ◽  
Author(s):  
Hong Yan ◽  
Cathleen Teh ◽  
Sivaramapanicker Sreejith ◽  
Liangliang Zhu ◽  
Anna Kwok ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Delivery

In vivo evaluation of an anticancer drug delivery system based on heparinized mesoporous silica nanoparticles

RSC Advances ◽  
2015 ◽  
Vol 5 (50) ◽  
pp. 40103-40110 ◽  
Author(s):  
Qiang Wu ◽  
Ruifang Li ◽  
Chao Zhao ◽  
Jiejie Ren ◽  
Keyuan Du ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Anticancer Drug ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
In Vivo Evaluation ◽  
Anticancer Drug Delivery

MSNs-HP loaded with only a low amount of a drug (DOX0.3) achieve a similar antitumor efficacy to that of large doses of the drug (DOX2.0, 7-fold higher in dosage than DOX0.3).

Functional Mesoporous Silica Nanoparticles for Photothermal-Controlled Drug Delivery In Vivo

2012 ◽  
Vol 51 (33) ◽  
pp. 8373-8377 ◽  
Author(s):  
Hong Yan ◽  
Cathleen Teh ◽  
Sivaramapanicker Sreejith ◽  
Liangliang Zhu ◽  
Anna Kwok ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Delivery

Biocompatible, Uniform, and Redispersible Mesoporous Silica Nanoparticles for Cancer-Targeted Drug Delivery In Vivo

2013 ◽  
Vol 24 (17) ◽  
pp. 2450-2461 ◽  
Author(s):  
Quan Zhang ◽  
Xiaoling Wang ◽  
Pei-Zhou Li ◽  
Kim Truc Nguyen ◽  
Xiao-Jun Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Targeted Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Targeted Drug

Multifunctional Peptide-Amphiphile End-Capped Mesoporous Silica Nanoparticles for Tumor Targeting Drug Delivery

2017 ◽  
Vol 9 (3) ◽  
pp. 2093-2103 ◽  
Author(s):  
Yin-Jia Cheng ◽  
Ai-Qing Zhang ◽  
Jing-Jing Hu ◽  
Feng He ◽  
Xuan Zeng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Tumor Targeting ◽  
Mesoporous Silica Nanoparticles ◽  
Peptide Amphiphile

scholarly journals Effect of Shape on Mesoporous Silica Nanoparticles for Oral Delivery of Indomethacin

Pharmaceutics ◽  
2018 ◽  
Vol 11 (1) ◽  
pp. 4 ◽  
Author(s):  
Wei Zhang ◽  
Nan Zheng ◽  
Lu Chen ◽  
Luyao Xie ◽  
Mingshu Cui ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Small Angle ◽  
Oral Delivery ◽  
Oral Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Oral Drug ◽  
Pharmacokinetic Studies

The use of mesoporous silica nanoparticles (MSNs) in the field of oral drug delivery has recently attracted greater attention. However, there is still limited knowledge about how the shape of MSNs affects drug delivery capacity. In our study, we fabricated mesoporous silica nanorods (MSNRs) to study the shape effects of MSNs on oral delivery. MSNRs were characterized by transmission electron microscopy (TEM), nitrogen adsorption/desorption, Fourier transform infrared spectroscopy (FTIR), and small-angle X-ray diffraction (small-angle XRD). Indomethacin (IMC), a non-steroidal anti-inflammatory agent, was loaded into MSNRs as model drug, and the drug-loaded MSNRs resulted in an excellent dissolution-enhancing effect. The cytotoxicity and in vivo pharmacokinetic studies indicated that MSNRs can be applied as a safe and efficient candidate for the delivery of insoluble drugs. The use of MSNs with a rod-like shape, as a drug delivery carrier, will extend the pharmaceutical applications of silica materials.

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