Gold Nanoparticle-Enhanced and Size-Dependent Generation of Reactive Oxygen Species from Protoporphyrin IX

ACS Nano ◽  
2012 ◽  
Vol 6 (3) ◽  
pp. 1939-1947 ◽  
Author(s):  
Maung Kyaw Khaing Oo ◽  
Yamin Yang ◽  
Yue Hu ◽  
Maria Gomez ◽  
Henry Du ◽  
...  
2019 ◽  
Vol 11 (11) ◽  
pp. 10589-10596 ◽  
Author(s):  
Jiayong Dai ◽  
Jibin Song ◽  
Yuan Qiu ◽  
Jingjing Wei ◽  
Zhongzhu Hong ◽  
...  

Author(s):  
Maung Kyaw Khaing Oo ◽  
Maria Gomez ◽  
Hongjun Wang ◽  
Henry Du

Reactive oxygen species (ROS) is a vital trigger for photodynamic therapy (PDT) of cancer. We report the production of elevated ROS using gold nanoparticles (GNP) (20–100 nm in diameter) conjugated with Protophorphyrin IX (PpIX). The amount of ROS formation increases with the size of the GNP due to enhanced electromagnetic field resulting from localized surface plasmonic resonance.


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