scholarly journals Multifunctional Plasmonic Shell–Magnetic Core Nanoparticles for Targeted Diagnostics, Isolation, and Photothermal Destruction of Tumor Cells

ACS Nano ◽  
2012 ◽  
Vol 6 (2) ◽  
pp. 1065-1073 ◽  
Author(s):  
Zhen Fan ◽  
Melanie Shelton ◽  
Anant Kumar Singh ◽  
Dulal Senapati ◽  
Sadia Afrin Khan ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Magnetic Core ◽  
Core Nanoparticles

scholarly journals A SYSTEM AND A DEVICE FOR ISOLATING CIRCULATING TUMOR CELLS FROM THE PERIPHERAL BLOOD IN VIVO

2015 ◽  
Vol 55 (4) ◽  
pp. 242
Author(s):  
Michal Mego ◽  
Miroslav Kocifaj ◽  
František Kundracik
Keyword(s):  
Stem Cells ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Peripheral Blood ◽  
Magnetic Core ◽  
Metastatic Cascade ◽  
Magnetic Shell ◽  
Rare Cells ◽  
New System

Circulating tumor cells (CTC) play a crucial role in disseminating tumors and in the metastatic cascade. CTCs are found only in small numbers, and the limited amount of isolated CTCs makes it impossible to characterize them closely. This paper presents a proposal for a new system for isolating CTCs from the peripheral blood in vivo. The system enables CTCs to be isolated from the whole blood volume for further research and applications. The proposed system consists of magnetic nanoparticles covered by monoclonal antibodies against a common epithelial antigen, large supermagnets, which are used to control the position of the nanoparticles within the human body, and a special wire made of a magnetic core wrapped in a non-magnetic shell. The system could be used not only for isolating CTCs, but also for in vivo isolation of other rare cells from the peripheral blood, including hematopoietic and/or mesenchymal stem cells, with applications in regenerative medicine and/or in stem cell transplantation.

scholarly journals Dynamic magnetic characterization and magnetic particle imaging enhancement of magnetic-gold core–shell nanoparticles

Nanoscale ◽  
2019 ◽  
Vol 11 (13) ◽  
pp. 6489-6496 ◽  
Author(s):  
Asahi Tomitaka ◽  
Satoshi Ota ◽  
Kizuku Nishimoto ◽  
Hamed Arami ◽  
Yasushi Takemura ◽  
...  
Keyword(s):  
Magnetic Particle ◽  
Magnetic Core ◽  
Gold Coating ◽  
Shell Nanoparticles ◽  
Gold Core ◽  
Magnetic Particle Imaging ◽  
Particle Imaging ◽  
Core Shell Nanoparticles ◽  
Imaging Performance ◽  
Core Nanoparticles

The gold coating on magnetic core nanoparticles enhanced magnetic particle imaging performance due to an alteration in dynamic magnetic responses.

scholarly journals Molecular and Cellular Risk Assessment of Healthy Human Cells and Cancer Human Cells Exposed to Nanoparticles

2019 ◽  
Vol 21 (1) ◽  
pp. 230 ◽  
Author(s):  
Edward Helal-Neto ◽  
Aline Oliveira da Silva de Barros ◽  
Roberta Saldanha-Gama ◽  
Renata Brandão-Costa ◽  
Luciana Magalhães Rebêlo Alencar ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Polymeric Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Colon Adenocarcinoma ◽  
Magnetic Core ◽  
Human Cells ◽  
The Body ◽  
Healthy Human ◽  
Lack Of Information ◽  
Great Debate

Nanodrugs have in recent years been a subject of great debate. In 2017 alone, almost 50 nanodrugs were approved for clinical use worldwide. Despite the advantages related to nanodrugs/nanomedicine, there is still a lack of information regarding the biological safety, as the real behavior of these nanodrugs in the body. In order to better understand these aspects, in this study, we evaluated the effect of polylactic acid (PLA) nanoparticles (NPs) and magnetic core mesoporous silica nanoparticles (MMSN), of 1000 nm and 50 nm, respectively, on human cells. In this direction we evaluated the cell cycle, cytochemistry, proliferation and tubulogenesis on tumor cells lines: from melanoma (MV3), breast cancer (MCF-7, MDA-MB-213), glioma (U373MG), prostate (PC3), gastric (AGS) and colon adenocarcinoma (HT-29) and non-tumor cell lines: from human melanocyte (NGM), fibroblast (FGH) and endothelial (HUVEC), respectively. The data showed that an acute exposure to both, polymeric nanoparticles or MMSN, did not show any relevant toxic effects on neither tumor cells nor non-tumor cells, suggesting that although nanodrugs may present unrevealed aspects, under acute exposition to human cells they are harmless.

Magnetic Radio Modifier Based on the Fe3O4/Ta2O5 Nanoparticles

2018 ◽  
Vol 386 ◽  
pp. 156-160
Author(s):  
Ksenya Sergeevna Lukуanenko ◽  
Vladimir Iosifovich Apanasevich ◽  
Leonid Lazarevich Afremov ◽  
Olga Vycheslavovna Tarakova ◽  
Olga Sergeevna Plotnikova ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Radiation Therapy ◽  
Tumor Cells ◽  
Magnetic Core ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
The Core ◽  
Electron Positron ◽  
Nanoparticles Concentration ◽  
Core Shell Nanoparticles

The possibility of application of magnetic core-shell Fe3O4/Ta2O5nanoparticles has been investigated in order to enhance the effect of radiation therapy. It has been shown, that an increase of the concentration of the core-shell nanoparticles due to the influence of the nonuniform magnetic field enhances the absorption of gamma quanta with energy destroying tumor cells (20-200 keV). In addition, an increase of nanoparticles concentration promotes the formation of electron-positron pairs, annihilation of which are leads to an increase in the number of secondary gamma quanta with an energy of 511 keV.

scholarly journals Sizing and Eddy currents in magnetic core nanoparticles: an optical extinction approach

2017 ◽  
Vol 19 (4) ◽  
pp. 3076-3083 ◽  
Author(s):  
Luis J. Mendoza Herrera ◽  
Ignacio J. Bruvera ◽  
Lucía B. Scaffardi ◽  
Daniel C. Schinca
Keyword(s):  
Size Distribution ◽  
Eddy Currents ◽  
Extinction Spectrum ◽  
Mie Theory ◽  
Magnetic Core ◽  
Frequency Dependent ◽  
Optical Extinction ◽  
Coating Layers ◽  
Core Nanoparticles

We extend the typical analysis of the extinction spectrum of magnetic core NPs by solving Mie theory with a frequency dependent susceptibility and considering the effect of Eddy currents in order to obtain the size distribution of the cores and the coating layers.

High quality and tuneable silica shell–magnetic core nanoparticles

2009 ◽  
Vol 12 (4) ◽  
pp. 1137-1147 ◽  
Author(s):  
Carmen Vogt ◽  
Muhammet S. Toprak ◽  
Mamoun Muhammed ◽  
Sophie Laurent ◽  
Jean-Luc Bridot ◽  
...  
Keyword(s):  
Magnetic Core ◽  
Silica Shell ◽  
High Quality ◽  
Core Nanoparticles

scholarly journals Development of Dextran-Coated Magnetic Nanoparticles Loaded with Protocatechuic Acid for Vascular Inflammation Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1414
Author(s):  
Maria Anghelache ◽  
Mihaela Turtoi ◽  
Anca Roxana Petrovici ◽  
Adrian Fifere ◽  
Mariana Pinteala ◽  
...  
Keyword(s):  
Protocatechuic Acid ◽  
Vascular Inflammation ◽  
Magnetic Core ◽  
Inflammatory Activity ◽  
Adhesion Assay ◽  
Theranostic Nanoparticles ◽  
Mitogen Activated Protein ◽  
Attractive Therapeutic Target ◽  
Anti Inflammatory ◽  
Core Nanoparticles

Vascular inflammation plays a crucial role in the progression of various pathologies, including atherosclerosis (AS), and thus it has become an attractive therapeutic target. The protocatechuic acid (PCA), one of the main metabolites of complex polyphenols, is endowed with anti-inflammatory activity, but its formulation into nanocarriers may increase its bioavailability. In this study, we developed and characterized dextran shell‒iron oxide core nanoparticles loaded with PCA (MNP-Dex/PCA) and assessed their cytotoxicity and anti-inflammatory potential on cells acting as key players in the onset and progression of AS, namely, endothelial cells (EC) and monocytes/macrophages. The results showed that MNP-Dex/PCA exert an anti-inflammatory activity at non-cytotoxic and therapeutically relevant concentrations of PCA (350 μM) as supported by the reduced levels of inflammatory molecules such as MCP-1, IL-1β, TNF-α, IL-6, and CCR2 in activated EC and M1-type macrophages and functional monocyte adhesion assay. The anti-inflammatory effect of MNP-Dex/PCA was associated with the reduction in the levels of ERK1/2 and p38-α mitogen-activated protein kinases (MAPKs) and NF-kB transcription factor. Our data support the further development of dextran shell-magnetic core nanoparticles as theranostic nanoparticles for guidance, imaging, and therapy of vascular inflammation using PCA or other anti-inflammatory compounds.

Facile Synthesis of Amino Shell-Magnetic Core Nanoparticles and Application for Direct Electrochemistry

2012 ◽  
Vol 45 (18) ◽  
pp. 2697-2706
Author(s):  
Shurui Cao ◽  
Lei Zhang ◽  
Xiaoling Zheng ◽  
Yaqin Chai ◽  
Ruo Yuan
Keyword(s):  
Direct Electrochemistry ◽  
Magnetic Core ◽  
Facile Synthesis ◽  
Core Nanoparticles
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