pH-Stimulated Concurrent Mechanical Activation of Two DNA “Tweezers”. A “SET−RESET” Logic Gate System

Nano Letters ◽  
2009 ◽  
Vol 9 (12) ◽  
pp. 4510-4514 ◽  
Author(s):  
Johann Elbaz ◽  
Zhen-Gang Wang ◽  
Ron Orbach ◽  
Itamar Willner
2019 ◽  
Vol 21 (30) ◽  
pp. 16798-16803 ◽  
Author(s):  
Weijie Chi ◽  
Jie Chen ◽  
Qinglong Qiao ◽  
Ying Gao ◽  
Zhaochao Xu ◽  
...  

We showed that TICT and PET were responsible for the off–on–off switching mechanisms of a fluorescent molecular logic gate.


2021 ◽  
Author(s):  
Jake Hanson ◽  
Sara Imari Walker

Integrated Information Theory is currently the leading mathematical theory of conscious- ness. The core of the theory relies on the calculation of a scalar mathematical measure of consciousness, Φ, which is deduced from the phenomenological axioms of the theory. Here, we show that despite its widespread use, Φ is not a well-defined mathematical concept in the sense that the value it specifies is neither unique nor specific. This problem, occasionally referred to as “undetermined qualia”, is the result of degeneracies in the optimization routine used to calculate Φ, which leads to ambiguities in determining the consciousness of systems under study. As demonstration, we first apply the mathematical definition of Φ to a simple AND+OR logic gate system and show 83 non-unique Φ values result, spanning a substantial portion of the range of possibilities. We then introduce a Python package called PyPhi-Spectrum which, unlike currently available packages, delivers the entire spectrum of possible Φ values for a given system. We apply this to a variety of examples of recently published calculations of Φ and show how virtually all Φ values from the sampled literature are chosen arbitrarily from a set of non-unique possibilities, the full range of which often includes both conscious and unconscious predictions. Lastly, we review proposed solutions to this degeneracy problem, and find none to provide a satisfactory solution, either because they fail to specify a unique Φ value or yield Φ = 0 for systems that are clearly integrated. We conclude with a discussion of requirements moving forward for scientifically valid theories of consciousness that avoid these degeneracy issues.


Nanoscale ◽  
2020 ◽  
Vol 12 (37) ◽  
pp. 19149-19158
Author(s):  
Jouharsha Afthab ◽  
Nafeesa Khatoon ◽  
Lulu Zhou ◽  
Tianming Yao ◽  
Shuo Shi

A silver nanoformulation for combating bacterial infections and its integration in Boolean analysis for the detection of multiple bacteria has been developed.


Author(s):  
Tomonori Kawano ◽  

Color is one of the most useful and attractive characteristics of light applicable to optical science and the related industries. In recent decades, a number of studies focusing on the use of light as a key component of computation have attracted considerable attention from researchers and engineers because these studies are potentially applicable to signal processing through optical interconnections between electronic devices. Such studies include the optical parallel logic gates proposed by a Japanese research group, allowing spontaneous and parallel computing with spatial coding using lights, simply by overlaying a pair of shadowgram images. For computational handling of the colors visible to human eyes,Commission Internationale de l’Eclairgehas defined CIE 1976 color space (CIELAB). The author has been engaged in the development of CIELAB-based printable and computable color codes possibly used for novel optical logic gate system as one of natural computing approaches. In the present study, by employing the pairs of CIELAB-coded-printed transparent films overlaid, a Boolean operation for the crossing (conjugation) of 2-by-2 color matrices based on the scanning of CIELAB values was demonstrated. This approach is still primitive but might be a significant step for manifesting the array-based processing of colors representing print-preserved and digitalized information.


RSC Advances ◽  
2017 ◽  
Vol 7 (67) ◽  
pp. 42345-42349 ◽  
Author(s):  
You Zhang ◽  
Xiangjiang Zheng ◽  
Lian Xia ◽  
Jinmao You ◽  
Rui Ren

A proof-of-principle logic system was established to process multi-input and multi-output logic relationships with the aim of identifying the tissue origins of cancer in light of their established relationships with miRNA distributions.


Sensors ◽  
2018 ◽  
Vol 18 (10) ◽  
pp. 3358 ◽  
Author(s):  
Xuemei Wu ◽  
Xiaoqing Bai ◽  
Yang Ma ◽  
Jie Wei ◽  
Juan Peng ◽  
...  

In this work, binary hydrogel films based on carboxylated multi-walled carbon nanotubes/poly(N,N-diethylacrylamide) (c-MWCNTs/PDEA) were successfully polymerized and assembled on a glassy carbon (GC) electrode surface. The electroactive drug probes matrine and sophoridine in solution showed reversible thermal-, salt-, methanol- and pH-responsive switchable cyclic voltammetric (CV) behaviors at the film electrodes. The control experiments showed that the pH-responsive property of the system could be ascribed to the drug components of the solutions, whereas the thermal-, salt- and methanol-sensitive behaviors were attributed to the PDEA constituent of the films. The CV signals particularly, of matrine and sophoridine were significantly amplified by the electrocatalysis of c-MWCNTs in the films at 1.02 V and 0.91 V, respectively. Moreover, the addition of esterase, urease, ethyl butyrate, and urea to the solution also changed the pH of the system, and produced similar CV peaks as with dilution by HCl or NaOH. Based on these experiments, a 6-input/5-output logic gate system and 2-to-1 encoder were successfully constructed. The present system may lead to the development of novel types of molecular computing systems.


The Analyst ◽  
2020 ◽  
Vol 145 (20) ◽  
pp. 6572-6578
Author(s):  
Xun Zhang ◽  
Qiang Zhang ◽  
Yuan Liu ◽  
Xiaopeng Wei

A switchable logic circuit which can represent three kinds of logical operations by adjusting concentration of silver ion and cysteine (Cys) based on E6 and Ag10c DNAzyme was developed.


2014 ◽  
Vol 10 (1) ◽  
pp. 225-230 ◽  
Author(s):  
Shuang Liu ◽  
Lei Wang ◽  
Wenjing Lian ◽  
Hongyun Liu ◽  
Chen-Zhong Li

2020 ◽  
Vol 9 (2) ◽  
pp. 316-328 ◽  
Author(s):  
Neža Omersa ◽  
Saša Aden ◽  
Matic Kisovec ◽  
Marjetka Podobnik ◽  
Gregor Anderluh

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