Tailored Magnetic Nanoparticles for Direct and Sensitive Detection of Biomolecules in Biological Samples

Nano Letters ◽  
2008 ◽  
Vol 8 (10) ◽  
pp. 3423-3428 ◽  
Author(s):  
Andrea Fornara ◽  
Petter Johansson ◽  
Karolina Petersson ◽  
Stefan Gustafsson ◽  
Jian Qin ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Biological Samples ◽  
Sensitive Detection ◽  
Detection Of Biomolecules

scholarly journals Magnetic nanoparticles for biomedical NMR-based diagnostics

2010 ◽  
Vol 1 ◽  
pp. 142-154 ◽  
Author(s):  
Huilin Shao ◽  
Tae-Jong Yoon ◽  
Monty Liong ◽  
Ralph Weissleder ◽  
Hakho Lee
Keyword(s):  
Magnetic Nanoparticles ◽  
Magnetic Resonance ◽  
Biological Samples ◽  
Low Cost ◽  
Disease Diagnosis ◽  
Protein Biomarkers ◽  
Resonance Effects ◽  
Wide Range ◽  
Detection Of Biomolecules

Rapid and accurate measurements of protein biomarkers, pathogens and cells in biological samples could provide useful information for early disease diagnosis, treatment monitoring, and design of personalized medicine. In general, biological samples have only negligible magnetic susceptibility. Thus, using magnetic nanoparticles for biosensing not only enhances sensitivity but also effectively reduces sample preparation needs. This review focuses on the use of magnetic nanoparticles for in vitro detection of biomolecules and cells based on magnetic resonance effects. This detection platform, termed diagnostic magnetic resonance (DMR), exploits magnetic nanoparticles as proximity sensors, which modulate the spin–spin relaxation time of water molecules surrounding molecularly-targeted nanoparticles. By developing more effective magnetic nanoparticle biosensors, DMR detection limits for various target moieties have been considerably improved over the last few years. Already, a library of magnetic nanoparticles has been developed, in which a wide range of targets, including DNA/mRNA, proteins, small molecules/drugs, bacteria, and tumor cells, have been quantified. More recently, the capabilities of DMR technology have been further advanced with new developments such as miniaturized nuclear magnetic resonance detectors, better magnetic nanoparticles and novel conjugational methods. These developments have enabled parallel and sensitive measurements to be made from small volume samples. Thus, the DMR technology is a highly attractive platform for portable, low-cost, and efficient biomolecular detection within a biomedical setting.

Low fouling and ultrasensitive electrochemical immunosensors with dual assay methods based on Fe3O4 magnetic nanoparticles

2019 ◽  
Vol 7 (38) ◽  
pp. 5842-5847 ◽  
Author(s):  
Wenshi Li ◽  
Gao-Chao Fan ◽  
Xiaojian Fan ◽  
Ruiqiao Zhang ◽  
Lei Wang ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Analytical Methods ◽  
Sensitive Detection ◽  
Fe3o4 Magnetic Nanoparticles ◽  
Cancer Antigen ◽  
Electrochemical Immunosensors ◽  
Highly Sensitive ◽  
Assay Methods ◽  
Highly Sensitive Detection

Low fouling electrochemical immunosensors for the highly sensitive detection of cancer antigen 15-3 with both “signal-off” and “signal-on” analytical methods were developed.

Synthesis of raspberry-like nanogapped Fe3O4@Au nanocomposites for SERS-based lateral flow detection of multiple tumor biomarkers

2020 ◽  
Vol 8 (37) ◽  
pp. 12854-12864 ◽  
Author(s):  
Wanzhu Shen ◽  
Chongwen Wang ◽  
Xingsheng Yang ◽  
Chaoguang Wang ◽  
Zihui Zhou ◽  
...  
Keyword(s):  
Biological Samples ◽  
Lateral Flow ◽  
Sensitive Detection ◽  
Tumor Biomarkers ◽  
Multiple Tumor ◽  
Flow Detection ◽  
Sers Tags

A novel magnetic SERS-LFA system with raspberry-like Fe3O4@Au MNPs as nanogapped SERS tags was proposed for the quantitative and ultra-sensitive detection of multiple tumor biomarkers in biological samples.

Luminescent magnetic nanoparticles encapsulated in MOFs for highly selective and sensitive detection of ClO−/SCN− and anti-counterfeiting

Nanoscale ◽  
2018 ◽  
Vol 10 (18) ◽  
pp. 8667-8676 ◽  
Author(s):  
Chaorui Li ◽  
Jun Hai ◽  
Siliang Li ◽  
Baodui Wang ◽  
Zhengyin Yang
Keyword(s):  
Magnetic Nanoparticles ◽  
Fluorescent Probe ◽  
Pure Water ◽  
High Sensitivity ◽  
Sensitive Detection ◽  
Zeolitic Imidazolate Framework ◽  
Framework Materials ◽  
Ultra Pure Water

Luminous Eu(iii) complex-functionalized Fe3O4 nanoparticles encapsulated into zeolitic imidazolate framework materials (nano-ZIF-8) were prepared and employed as a fluorescent probe for detecting ClO− and SCN− with good selectivity and high sensitivity in ultra-pure water.

Number sensitive detection and direct imaging of dipolar coupled magnetic nanoparticles by tunnel magnetoresistive sensors

2009 ◽  
Vol 95 (16) ◽  
pp. 163106 ◽  
Author(s):  
C. Albon ◽  
A. Weddemann ◽  
A. Auge ◽  
D. Meißner ◽  
K. Rott ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Sensitive Detection ◽  
Direct Imaging ◽  
Magnetoresistive Sensors
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