Cell Type Determines the Light-Induced Endosomal Escape Kinetics of Multifunctional Mesoporous Silica Nanoparticles

Nano Letters ◽  
2013 ◽  
Vol 13 (3) ◽  
pp. 1047-1052 ◽  
Author(s):  
Maria Pamela Dobay ◽  
Alexandra Schmidt ◽  
Eduardo Mendoza ◽  
Thomas Bein ◽  
Joachim O. Rädler
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Endosomal Escape ◽  
Cell Type ◽  
Kinetics Of

scholarly journals Sterically Stabilised Polymeric Mesoporous Silica Nanoparticles Improve Doxorubicin Efficiency: Tailored Cancer Therapy

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 742 ◽  
Author(s):  
Thashini Moodley ◽  
Moganavelli Singh
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Release Kinetics ◽  
Drug Delivery Vehicles ◽  
Biological Compatibility ◽  
Delivery Vehicles ◽  
Efficient Loading ◽  
Kinetics Of

The fruition, commercialisation and clinical application combining nano-engineering, nanomedicine and material science for utilisation in drug delivery is becoming a reality. The successful integration of nanomaterial in nanotherapeutics requires their critical development to ensure physiological and biological compatibility. Mesoporous silica nanoparticles (MSNs) are attractive nanocarriers due to their biodegradable, biocompatible, and relative malleable porous frameworks that can be functionalized for enhanced targeting and delivery in a variety of disease models. The optimal formulation of an MSN with polyethylene glycol (2% and 5%) and chitosan was undertaken, to produce sterically stabilized, hydrophilic MSNs, capable of efficient loading and delivery of the hydrophobic anti-neoplastic drug, doxorubicin (DOX). The pH-sensitive release kinetics of DOX, together with the anticancer, apoptosis and cell-cycle activities of DOX-loaded MSNs in selected cancer cell lines were evaluated. MSNs of 36–60 nm in size, with a pore diameter of 9.8 nm, and a cumulative surface area of 710.36 m2/g were produced. The 2% pegylated MSN formulation (PCMSN) had the highest DOX loading capacity (0.98 mgdox/mgmsn), and a sustained release profile over 72 h. Pegylated-drug nanoconjugates were effective at a concentration range between 20–50 μg/mL, inducing apoptosis in cancer cells, and affirming their potential as effective drug delivery vehicles.

Comparative release kinetics of small drugs (ibuprofen and acetaminophen) from multifunctional mesoporous silica nanoparticles

2020 ◽  
Vol 8 (10) ◽  
pp. 2096-2106 ◽  
Author(s):  
Eun-Bi Lim ◽  
Tran Anh Vy ◽  
Sang-Wha Lee
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Intermolecular Interactions ◽  
Mesoporous Silica Nanoparticles ◽  
Release Kinetics ◽  
Kinetics Of

Multifunctional mesoporous silica nanoparticles (MSNs) can confer dynamically varied release kinetics depending on the intermolecular interactions between model drugs and functional decorations on the MSNs.

Dissolution kinetics of mesoporous silica nanoparticles in different simulated body fluids

2016 ◽  
Vol 79 (2) ◽  
pp. 319-327 ◽  
Author(s):  
Katharina Braun ◽  
Alexander Pochert ◽  
Michaela Beck ◽  
Richard Fiedler ◽  
Jens Gruber ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Dissolution Kinetics ◽  
Body Fluids ◽  
Simulated Body Fluids ◽  
Kinetics Of

scholarly journals Dendronized mesoporous silica nanoparticles provide an internal endosomal escape mechanism for successful cytosolic drug release

2016 ◽  
Vol 227 ◽  
pp. 242-251 ◽  
Author(s):  
Veronika Weiss ◽  
Christian Argyo ◽  
Adriano A. Torrano ◽  
Claudia Strobel ◽  
Stephan A. Mackowiak ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Endosomal Escape ◽  
Escape Mechanism

In-depth study on the gene silencing capability of silica nanoparticles with different pore sizes: degree and duration of RNA interference

RSC Advances ◽  
2016 ◽  
Vol 6 (32) ◽  
pp. 27143-27150 ◽  
Author(s):  
Seongchan Kim ◽  
Hee-Kyung Na ◽  
Cheolhee Won ◽  
Dal-Hee Min
Keyword(s):  
Rna Interference ◽  
Mesoporous Silica ◽  
Gene Silencing ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Sirna Delivery ◽  
Pore Sizes ◽  
Depth Study ◽  
Kinetics Of ◽  
Sirna Delivery System

The mesoporous silica nanoparticles (MSN) having different pore sizes were synthesized and utilized for siRNA delivery system capable of controlling kinetics of RNA interference.

scholarly journals Functionalized Mesoporous Silica Nanoparticles as Delivery Systems for Doxorubicin: Drug Loading and Release

2021 ◽  
Vol 11 (13) ◽  
pp. 6121
Author(s):  
Candace M. Day ◽  
Martin J. Sweetman ◽  
Yunmei Song ◽  
Sally E. Plush ◽  
Sanjay Garg
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Release Kinetics ◽  
Drug Loading ◽  
In Vitro Release ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Kinetics Of

Functionalized nanoparticles have played a major role in the field of targeted therapy, owing to their ability to control the release and for the selective delivery of entrapped materials to tumours. In this work, we described the loading capacity and in vitro release kinetics of mesoporous silica nanoparticles (MSNs), functionalized with Poly-L-Histidine and Tamoxifen. The model drug Doxorubicin (DOX) was successfully encapsulated into MSN-based systems, using the technique of solvent immersion. A post-surface grafting loading method was investigated on functionalized systems, with DOX loading content determined using HPLC. Dialysis bag diffusion was employed to investigate the release kinetics of DOX-loaded-systems at pH 7.4 and 5. The amount of DOX released from native MSNs systems over a 72 h period at pH 5 was approximately 40%; and at pH 7.4 ≈ 30%. A moderate pH dependent release behaviour was observed with both our functionalized systems: DOX@MSN-PLH and DOX@MSN-PLH-TAM; with approximately 5% of DOX released from DOX@MSN-PLH-TAM at pH 7.4 and about 9% released at pH 7.4 over 72 h. The maximal cumulated release of DOX molecules from DOX@MSN-PLH after 72 h was ≈ 18% at pH 7.4 and ≈ 23% at pH 5, respectively. The outcome of this work offers a promising contribution towards building future stimuli-responsive nano-drug delivery systems.

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