Magnetoporation and Magnetolysis of Cancer Cells via Carbon Nanotubes Induced by Rotating Magnetic Fields

Nano Letters ◽  
2012 ◽  
Vol 12 (10) ◽  
pp. 5117-5121 ◽  
Author(s):  
Dun Liu ◽  
Lijun Wang ◽  
Zhigang Wang ◽  
Alfred Cuschieri
Keyword(s):  
Carbon Nanotubes ◽  
Magnetic Fields ◽  
Cancer Cells ◽  
Rotating Magnetic Fields

scholarly journals Enhancing cellular morphological changes and ablation of cancer cells via the interaction of drug co-loaded magnetic nanosystems in weak rotating magnetic fields

RSC Advances ◽  
2020 ◽  
Vol 10 (25) ◽  
pp. 14471-14481
Author(s):  
Tingting Wu ◽  
Qian Zhang ◽  
Huiping Hu ◽  
Fang Yang ◽  
Ke Li ◽  
...  
Keyword(s):  
Magnetic Fields ◽  
Cancer Cells ◽  
Morphological Changes ◽  
Rotating Magnetic Fields ◽  
Rotational Movement ◽  
Apoptotic Effect

Tetrandrine and Fe3O4 nanoparticle co-loaded PLGA nanosystems produce rotational movement and promote tetrandrine release, causing a dual apoptotic effect to tumors.

scholarly journals Rotating Magnetic Fields Inhibit Mitochondrial Respiration, Promote Oxidative Stress and Produce Loss of Mitochondrial Integrity in Cancer Cells

2021 ◽  
Vol 11 ◽  
Author(s):  
Martyn A. Sharpe ◽  
David S. Baskin ◽  
Kumar Pichumani ◽  
Omkar B. Ijare ◽  
Santosh A. Helekar
Keyword(s):  
Cell Death ◽  
Electron Transport ◽  
Magnetic Fields ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Rat Liver ◽  
Electron Flow ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Rotating Magnetic Fields

Electromagnetic fields (EMF) raise intracellular levels of reactive oxygen species (ROS) that can be toxic to cancer cells. Because weak magnetic fields influence spin state pairing in redox-active radical electron pairs, we hypothesize that they disrupt electron flow in the mitochondrial electron transport chain (ETC). We tested this hypothesis by studying the effects of oscillating magnetic fields (sOMF) produced by a new noninvasive device involving permanent magnets spinning with specific frequency and timing patterns. We studied the effects of sOMF on ETC by measuring the consumption of oxygen (O2) by isolated rat liver mitochondria, normal human astrocytes, and several patient derived brain tumor cells, and O2 generation/consumption by plant cells with an O2 electrode. We also investigated glucose metabolism in tumor cells using 1H and 13C nuclear magnetic resonance and assessed mitochondrial alterations leading to cell death by using fluorescence microscopy with MitoTracker™ and a fluorescent probe for Caspase 3 activation. We show that sOMF of appropriate field strength, frequency, and on/off profiles completely arrest electron transport in isolated, respiring, rat liver mitochondria and patient derived glioblastoma (GBM), meningioma and diffuse intrinsic pontine glioma (DIPG) cells and can induce loss of mitochondrial integrity. These changes correlate with a decrease in mitochondrial carbon flux in cancer cells and with cancer cell death even in the non-dividing phase of the cell cycle. Our findings suggest that rotating magnetic fields could be therapeutically efficacious in brain cancers such as GBM and DIPG through selective disruption of the electron flow in immobile ETC complexes.

scholarly journals Multi-Walled Carbon Nanotubes Decorated with Guanidinylated Dendritic Molecular Transporters: An Efficient Platform for the Selective Anticancer Activity of Doxorubicin

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 858
Author(s):  
Kyriaki-Marina Lyra ◽  
Archontia Kaminari ◽  
Katerina N. Panagiotaki ◽  
Konstantinos Spyrou ◽  
Sergios Papageorgiou ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Delivery System ◽  
Colloidal Stability ◽  
Triggered Release ◽  
Selective Toxicity ◽  
Molecular Transporters ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

An efficient doxorubicin (DOX) drug delivery system with specificity against tumor cells was developed, based on multi-walled carbon nanotubes (MWCNTs) functionalized with guanidinylated dendritic molecular transporters. Acid-treated MWCNTs (oxCNTs) interacted both electrostatically and through hydrogen bonding and van der Waals attraction forces with guanidinylated derivatives of 5000 and 25,000 Da molecular weight hyperbranched polyethyleneimine (GPEI5K and GPEI25K). Chemical characterization of these GPEI-functionalized oxCNTs revealed successful decoration with GPEIs all over the oxCNTs sidewalls, which, due to the presence of guanidinium groups, gave them aqueous compatibility and, thus, exceptional colloidal stability. These GPEI-functionalized CNTs were subsequently loaded with DOX for selective anticancer activity, yielding systems of high DOX loading, up to 99.5% encapsulation efficiency, while the DOX-loaded systems exhibited pH-triggered release and higher therapeutic efficacy compared to that of free DOX. Most importantly, the oxCNTs@GPEI5K-DOX system caused high and selective toxicity against cancer cells in a non-apoptotic, fast and catastrophic manner that cancer cells cannot recover from. Therefore, the oxCNTs@GPEI5K nanocarrier was found to be a potent and efficient nanoscale DOX delivery system, exhibiting high selectivity against cancerous cells, thus constituting a promising candidate for cancer therapy.

Earth optimization of space experiment on growth of germanium by floating-zone technique with the use of rotating magnetic fields

2001 ◽  
Vol 46 (1) ◽  
pp. 148-153 ◽  
Author(s):  
A. V. Kartavykh ◽  
É. S. Kopeliovich ◽  
M. G. Mil’vidskii ◽  
V. V. Rakov
Keyword(s):  
Magnetic Fields ◽  
Space Experiment ◽  
Floating Zone ◽  
Rotating Magnetic Fields

Eddy current tomography using rotating magnetic fields for deep SQUID NDE

1997 ◽  
Vol 10 (12) ◽  
pp. 901-903
Author(s):  
A Haller ◽  
Y Tavrin ◽  
H-J Krause ◽  
P David ◽  
A I Braginski
Keyword(s):  
Magnetic Fields ◽  
Eddy Current ◽  
Rotating Magnetic Fields
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