Cytosolic Delivery of Membrane-Impermeable Molecules in Dendritic Cells Using pH-Responsive Core−Shell Nanoparticles

Nano Letters ◽  
2007 ◽  
Vol 7 (10) ◽  
pp. 3056-3064 ◽  
Author(s):  
Yuhua Hu ◽  
Tamara Litwin ◽  
Arpun R. Nagaraja ◽  
Brandon Kwong ◽  
Joshua Katz ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Core Shell ◽  
Ph Responsive ◽  
Shell Nanoparticles ◽  
Cytosolic Delivery ◽  
Core Shell Nanoparticles

Highly efficient sunitinib release from pH-responsive mHPMC@Chitosan core-shell nanoparticles

2021 ◽  
Vol 258 ◽  
pp. 117719
Author(s):  
Hessam Jafari ◽  
Gholam Reza Mahdavinia ◽  
Bagher Kazemi ◽  
Hermann Ehrlich ◽  
Yvonne Joseph ◽  
...  
Keyword(s):  
Core Shell ◽  
Ph Responsive ◽  
Shell Nanoparticles ◽  
Highly Efficient ◽  
Core Shell Nanoparticles

Rationale Design of pH-Responsive Core–Shell Nanoparticles: Polyoxometalate-Mediated Structural Reorganization

2020 ◽  
Vol 3 (11) ◽  
pp. 11247-11253
Author(s):  
Yanting Gao ◽  
Jingjing Xu ◽  
Changhe Zhang ◽  
Hariprasad Venugopal ◽  
Sarah S. Kermaniyan ◽  
...  
Keyword(s):  
Core Shell ◽  
Ph Responsive ◽  
Structural Reorganization ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

scholarly journals Multifunctional chitosan modified Gd2O3:Yb3+,Er3+@nSiO2@mSiO2 core/shell nanoparticles for pH responsive drug delivery and bioimaging

RSC Advances ◽  
2017 ◽  
Vol 7 (17) ◽  
pp. 10287-10294 ◽  
Author(s):  
Shanshan Huang ◽  
Ping'an Ma ◽  
Ziyong Cheng ◽  
Bei Liu ◽  
Xiaoran Deng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Core Shell ◽  
Ph Responsive ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

Chitosan modified Gd2O3:Yb3+,Er3+@nSiO2@mSiO2 core/shell nanoparticles were synthesized for pH responsive drug delivery and bioimaging.

scholarly journals Synthesis, Characterization, and Drug Delivery from pH- and Thermoresponsive Poly(N-Isopropylacrylamide)/Chitosan Core/Shell Nanocomposites Made by Semicontinuous Heterophase Polymerization

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Abraham G. Alvarado ◽  
Andres Ortega ◽  
Lourdes A. Pérez-Carrillo ◽  
Israel Ceja ◽  
Martin Arellano ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Crosslinking Agent ◽  
Core Shell ◽  
Ph Responsive ◽  
Doxycycline Hyclate ◽  
Shell Nanoparticles ◽  
Heterophase Polymerization ◽  
Heating And Cooling ◽  
Core Shell Nanoparticles ◽  
Semicontinuous Heterophase Polymerization

Temperature- and pH-responsive core/shell nanoparticles were prepared by semicontinuous heterophase polymerization of N-isopropylacrylamide (NIPA) in the presence of chitosan micelles for drug delivery purposes. Micelles of chitosan, formed in an acetic acid aqueous solution at 70°C containing potassium persulfate, were fed with N-isopropylacrylamide (NIPA) at a controlled rate, to produce PNIPA/chitosan core/shell nanoparticles of about 350 nm. Then, the crosslinking agent, glutaraldehyde, was added to crosslink the nanoparticles. These nanocomposites were temperature- and pH-responsive, which make them suitable as controlled drug releasing agents. The nanoparticles exhibit thermoreversibility to heating-and-cooling cycles and show different responses depending on the releasing medium’s pH. Drug delivery tests were performed, employing as a model drug, doxycycline hyclate.

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