Multihydroxylated [Gd@C82(OH)22]nNanoparticles:  Antineoplastic Activity of High Efficiency and Low Toxicity

Nano Letters ◽  
2005 ◽  
Vol 5 (10) ◽  
pp. 2050-2057 ◽  
Author(s):  
Chunying Chen ◽  
Gengmei Xing ◽  
Jiangxue Wang ◽  
Yuliang Zhao ◽  
Bai Li ◽  
...  
Keyword(s):  
High Efficiency ◽  
Antineoplastic Activity ◽  
Low Toxicity

scholarly journals Pathogenesis and Potential Therapeutic Targets for Triple-Negative Breast Cancer

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2978
Author(s):  
Chia-Jung Li ◽  
Yen-Dun Tony Tzeng ◽  
Yi-Han Chiu ◽  
Hung-Yu Lin ◽  
Ming-Feng Hou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Targeted Therapy ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
High Efficiency ◽  
Early Recurrence ◽  
New Developments ◽  
Great Progress ◽  
Low Toxicity ◽  
Made In

Triple negative breast cancer (TNBC) is a heterogeneous tumor characterized by early recurrence, high invasion, and poor prognosis. Currently, its treatment includes chemotherapy, which shows a suboptimal efficacy. However, with the increasing studies on TNBC subtypes and tumor molecular biology, great progress has been made in targeted therapy for TNBC. The new developments in the treatment of breast cancer include targeted therapy, which has the advantages of accurate positioning, high efficiency, and low toxicity, as compared to surgery, radiotherapy, and chemotherapy. Given its importance as cancer treatment, we review the latest research on the subtypes of TNBC and relevant targeted therapies.

scholarly journals Mitochondria-targeting fluorescent molecules for high efficiency cancer growth inhibition and imaging

2019 ◽  
Vol 10 (34) ◽  
pp. 7946-7951 ◽  
Author(s):  
Hao Chen ◽  
Jing Wang ◽  
Xin Feng ◽  
Mark Zhu ◽  
Simon Hoffmann ◽  
...  
Keyword(s):  
Growth Inhibition ◽  
High Efficiency ◽  
Clinical Translation ◽  
Cancer Growth ◽  
Lipophilic Cations ◽  
Anti Cancer ◽  
Low Toxicity ◽  
Fluorescent Molecules ◽  
Mitochondria Targeting

5BMF is a new fluorescent mitochondria-accumulating delocalized lipophilic cations [DLC] that boasts significantly increased anti-cancer effects and low toxicity in comparison to previous DLCs, addressing current hurdles in DLC clinical translation.

scholarly journals The Development of Functional Non-Viral Vectors for Gene Delivery

2019 ◽  
Vol 20 (21) ◽  
pp. 5491 ◽  
Author(s):  
Patil ◽  
Gao ◽  
Lin ◽  
Li ◽  
Dang ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Targeted Delivery ◽  
Viral Vectors ◽  
High Efficiency ◽  
Transfection Efficiency ◽  
Cationic Lipids ◽  
Gene Vectors ◽  
Potential Applications ◽  
Low Toxicity ◽  
Low Cytotoxicity

Gene therapy is manipulation in/of gene expression in specific cells/tissue to treat diseases. This manipulation is carried out by introducing exogenous nucleic acids, such as DNA or RNA, into the cell. Because of their negative charge and considerable larger size, the delivery of these molecules, in general, should be mediated by gene vectors. Non-viral vectors, as promising delivery systems, have received considerable attention due to their low cytotoxicity and non-immunogenicity. As research continued, more and more functional non-viral vectors have emerged. They not only have the ability to deliver a gene into the cells but also have other functions, such as the performance of fluorescence imaging, which aids in monitoring their progress, targeted delivery, and biodegradation. Recently, many reviews related to non-viral vectors, such as polymers and cationic lipids, have been reported. However, there are few reviews regarding functional non-viral vectors. This review summarizes the common functional non-viral vectors developed in the last ten years and their potential applications in the future. The transfection efficiency and the transport mechanism of these materials were also discussed in detail. We hope that this review can help researchers design more new high-efficiency and low-toxicity multifunctional non-viral vectors, and further accelerate the progress of gene therapy.

scholarly journals Disarmed anthrax toxin delivers antisense oligonucleotides and siRNA with high efficiency and low toxicity

2015 ◽  
Vol 220 ◽  
pp. 316-328 ◽  
Author(s):  
Paul D.R. Dyer ◽  
Thomas R. Shepherd ◽  
Alexander S. Gollings ◽  
Susan A. Shorter ◽  
Monique A.M. Gorringe-Pattrick ◽  
...  
Keyword(s):  
Antisense Oligonucleotides ◽  
High Efficiency ◽  
Anthrax Toxin ◽  
Low Toxicity

scholarly journals Specific AAV serotypes stably transduce primary hippocampal and cortical cultures with high efficiency and low toxicity

2008 ◽  
Vol 1190 ◽  
pp. 15-22 ◽  
Author(s):  
Nicolas C. Royo ◽  
Luk H. Vandenberghe ◽  
Jing-Yuan Ma ◽  
Alisse Hauspurg ◽  
LiYa Yu ◽  
...  
Keyword(s):  
High Efficiency ◽  
Cortical Cultures ◽  
Low Toxicity

Low toxicity environmentally friendly single component aqueous organic ionic conductors for high efficiency photoelectrochemical solar cells

2018 ◽  
Vol 6 (3) ◽  
pp. 1009-1016 ◽  
Author(s):  
Jayraj V. Vaghasiya ◽  
Dilip Krishna Nandakumar ◽  
Zhang Yaoxin ◽  
Swee Ching Tan
Keyword(s):  
Solar Cells ◽  
High Efficiency ◽  
Dye Sensitized Solar Cells ◽  
Single Component ◽  
Ionic Conductors ◽  
Environment Friendly ◽  
Dye Sensitized ◽  
Photoelectrochemical Solar Cells ◽  
Low Toxicity ◽  
Sensitized Solar Cells

Low-toxic, environment friendly single component organic ionic conductors are synthesized by facile methods and used as electrolytes in Dye Sensitized Solar Cells (DSSCs).

scholarly journals Research Progress on Toxicity of Natural Compounds

2021 ◽  
Vol 5 (2) ◽  
Author(s):  
Zhangping Zhou ◽  
Zilong Fu ◽  
Yan Li ◽  
Biao Ren ◽  
Ling Duan ◽  
...  
Keyword(s):  
Natural Resources ◽  
High Efficiency ◽  
Natural Compounds ◽  
Research Progress ◽  
Rational Utilization ◽  
Active Compounds ◽  
Natural Substances ◽  
Low Toxicity ◽  
Further Development ◽  
Active Substances

There are many active substances in natural resources. After years of research, researchers at home and abroad have extracted active compounds and proved that these compounds have low toxicity and high efficiency, but the toxicity of these compounds cannot be ignored. In this paper, the research progress on the toxicity of compounds isolated from various natural substances is reviewed, which provides a reference for the further development and rational utilization of natural compounds.

scholarly journals A Novel Sulfonated Derivative of β-Cyclodextrin Effectively Inhibits Influenza A Virus Infection in vitro and in vivo

Acta Naturae ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 20-30 ◽  
Author(s):  
E. P. Goncharova ◽  
Y. A. Kostyro ◽  
A. V. Ivanov ◽  
M. A. Zenkova
Keyword(s):  
Influenza Virus ◽  
Influenza A ◽  
High Efficiency ◽  
Influenza Infection ◽  
Lethal Infection ◽  
Novel Drugs ◽  
Infected Cells ◽  
Low Toxicity

The development of novel drugs against the influenza virus with high efficiency and low toxicity is an urgent and important task. Previous reports have demonstrated that compounds based on sulfo derivatives of oligo- and polysaccharides possess high antiviral activity. In this study, we have examined the ability of a novel sulfonated derivative of -cyclodextrin (KS-6469) to inhibit the influenza virus A/WSN/33 (H1N1) infection in vitro and in vivo. The antiviral potential of KS-6469 against the influenza virus was evaluated in Madin-Darby Canine Kidney epithelial cells treated with serially diluted KS-6469. We found out that KS-6469 completely inhibited viral reproduction after treatment of the infected cells with the compound for 48 h. Our data show that double intranasal treatment of mice with KS-6469 fully protected the animals from a lethal infection and significantly decreased the viral titers in the lungs of the infected animals. Thus, the novel sulfonated -cyclodextrin derivative KS-6469 is a promising candidate for the development of antiviral drugs for preventing and treating the influenza infection.

scholarly journals iTRAQ-based proteomic analysis reveals the mechanisms of Botrytis cinerea controlled with Wuyiencin

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Liming Shi ◽  
Beibei Ge ◽  
Jinzi Wang ◽  
Binghua Liu ◽  
Jinjin Ma ◽  
...  
Keyword(s):  
Botrytis Cinerea ◽  
Plant Disease ◽  
High Efficiency ◽  
Biological Effects ◽  
Plant Stress ◽  
Grey Mould ◽  
Economic Loss ◽  
Reaction Monitoring ◽  
Parallel Reaction Monitoring ◽  
Low Toxicity

Abstract Background Grey mould is an important plant disease worldwide, caused by Botrytis cinerea, resulting in serious economic loss. Wuyiencin, a low toxicity, high efficiency, and broad-spectrum agricultural antibiotic, has been demonstrated effectiveness against B. cinerea. Results Wuyiencin treatment inhibited growth and sporulation of B. cinerea, specifically altering hypha morphology and intracellular structures. These changes were accompanied by differential expression (fold change > 2.0) of 316 proteins identified by iTRAQ-labelling LC-MS/MS analysis (P < 0.05). Up-regulation of 14 proteins, including carbohydrate metabolism proteins and cell wall stabilization proteins, was validated by parallel reaction monitoring (PRM). Down-regulation of 13 proteins was validated by PRM, including regulators of energy metabolism, nucleotide/protein synthesis, and the biosynthesis of mediators of plant stress and decay. Conclusion Our results confirm the inhibitory biological effects of wuyiencin on B. cinereal and elaborate on the differentially expressed proteins and associated pathways implicated in the capacity of wuyiencin to debilitate the growth and pathogenicity of grey mould. This study provides validated candidates for further targeted exploration with the goal of optimizing wuyiencin as a safe, low-toxicity agent for biological control.

Sign in / Sign up

Export Citation Format

Share Document