Antiangiogenic Gene Therapy of Solid Tumor by Systemic Injection of Polyplex Micelles Loading Plasmid DNA Encoding Soluble Flt-1

2010 ◽  
Vol 7 (2) ◽  
pp. 501-509 ◽  
Author(s):  
Makoto Oba ◽  
Yelena Vachutinsky ◽  
Kanjiro Miyata ◽  
Mitsunobu R. Kano ◽  
Sorato Ikeda ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Solid Tumor ◽  
Plasmid Dna ◽  
Dna Encoding ◽  
Systemic Injection

scholarly journals A gene therapy for cancer using intramuscular injection of plasmid DNA encoding interferon  

1999 ◽  
Vol 96 (4) ◽  
pp. 1553-1558 ◽  
Author(s):  
H. M. Horton ◽  
D. Anderson ◽  
P. Hernandez ◽  
K. M. Barnhart ◽  
J. A. Norman ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Plasmid Dna ◽  
Intramuscular Injection ◽  
Dna Encoding

GENE THERAPY WITH NAKED PLASMID DNA ENCODING VEGF121 LEADS TO REVASCULARIZATION OF ISCHEMIC TISSUE IN ANIMAL MODELS OF VASCULAR DISEASES

2004 ◽  
Vol 13 (3) ◽  
pp. 24
Author(s):  
Nelson Santiago Vispo ◽  
Ariana Garcia Ojalvo ◽  
Alina Seralena ◽  
Ricardo Silva ◽  
Yaquelin Puchades ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Animal Models ◽  
Plasmid Dna ◽  
Vascular Diseases ◽  
Dna Encoding ◽  
Ischemic Tissue ◽  
Naked Plasmid ◽  
Naked Plasmid Dna

Ultrasound-Enhanced Chemotherapy and Gene Delivery for Glioma Cells

2007 ◽  
Vol 6 (5) ◽  
pp. 433-442 ◽  
Author(s):  
Vladimir G. Zarnitsyn ◽  
Pavel P. Kamaev ◽  
Mark R. Prausnitz
Keyword(s):  
Gene Therapy ◽  
Brain Cancer ◽  
Plasmid Dna ◽  
Glioma Cells ◽  
Intracellular Delivery ◽  
Intracellular Uptake ◽  
Dna Encoding ◽  
Ultrasound Exposure ◽  
Gfp Reporter

Treatment of brain cancer is limited in part by inefficient intracellular delivery of drugs and DNA for chemotherapy and gene therapy, respectively. This study tested the hypothesis that ultrasound may be used to enhance intracellular delivery and efficacy of chemotherapeutics and genes in glioma cells in vitro. First, suitable ultrasound conditions were identified by measuring intracellular uptake of calcein and viability of GS 9L rat gliosarcoma cells after a range of different ultrasound exposures. We selected sonication at 10 J/cm2, which achieved intracellular delivery of ν106 molecules/cell. Next, glial cells were sonicated with varying concentrations of model chemotherapeutics: BCNU and bleomycin. For both drugs, cytotoxicity was increased in a synergistic manner when accompanied by ultrasound exposure. Finally, expression of a plasmid DNA encoding a GFP reporter was increased up to 30-fold when exposed to ultrasound. Altogether, these findings suggest that ultrasound may be useful to increase the efficacy of chemotherapy and gene therapy of glioma cells.

Production of plasmid DNA encoding human hepatocyte growth factor for gene therapy

2008 ◽  
Vol 49 (1) ◽  
pp. 11 ◽  
Author(s):  
Qinglin Zhang ◽  
Jianjing Bi ◽  
Fengjun Xiao ◽  
Haifeng Duan ◽  
Bing Wu ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Plasmid Dna ◽  
Human Hepatocyte ◽  
Dna Encoding ◽  
Human Hepatocyte Growth Factor ◽  
Hepatocyte Growth

scholarly journals Gene Therapy Using Plasmid DNA Encoding VEGF164 and FGF2 Genes: A Novel Treatment of Naturally Occurring Tendinitis and Desmitis in Horses

2018 ◽  
Vol 9 ◽  
Author(s):  
Milomir Kovac ◽  
Yaroslav A. Litvin ◽  
Ruslan O. Aliev ◽  
Elena Y. Zakirova ◽  
Catrin S. Rutland ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Plasmid Dna ◽  
Dna Encoding ◽  
Naturally Occurring ◽  
Novel Treatment
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