Dendimer-Mediated Solubilization, Formulation Development and in Vitro−in Vivo Assessment of Piroxicam

2009 ◽  
Vol 6 (3) ◽  
pp. 940-950 ◽  
Author(s):  
Ram N. Prajapati ◽  
Rakesh K. Tekade ◽  
Umesh Gupta ◽  
Virendra Gajbhiye ◽  
Narendra K. Jain
Keyword(s):  
Formulation Development ◽  
In Vivo Assessment

Formulation development and in vitro–in vivo assessment of protransfersomal gel of anti-resorptive drug in osteoporosis treatment

2021 ◽  
pp. 121060
Author(s):  
Suman Gyanewali ◽  
Prashant Kesharwani ◽  
Afsana ◽  
Farhan Jalees Ahmad ◽  
Ritu Trivedi ◽  
...  
Keyword(s):  
Osteoporosis Treatment ◽  
Formulation Development ◽  
In Vivo Assessment

Transdermal Prodrug Delivery for Radionuclide Decorporation: Nonaqueous Gel Formulation Development and In Vitro and In Vivo Assessment

2013 ◽  
Vol 74 (5) ◽  
pp. 322-331 ◽  
Author(s):  
Yong Zhang ◽  
Matthew P. Sadgrove ◽  
Russell J. Mumper ◽  
Michael Jay
Keyword(s):  
Formulation Development ◽  
Nonaqueous Gel ◽  
In Vivo Assessment

scholarly journals In vivo assessment of a single adenine mutation in 5′UTR of Endothelin-1 gene in paediatric cases with severe pulmonary hypertension: an observational study

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Abhishek Kumar ◽  
Minati Choudhury ◽  
Sakshi Dhingra Batra ◽  
Kriti Sikri ◽  
Anushree Gupta
Keyword(s):  
Pulmonary Hypertension ◽  
Congenital Heart ◽  
Small Sample Size ◽  
Small Sample ◽  
Severe Pulmonary Hypertension ◽  
Endothelin 1 ◽  
Circulating Levels ◽  
In Vivo Assessment

Abstract Objective Endothelin-1 plays an important role in the pathogenesis of severe pulmonary hypertension. The + 139 ‘A’, adenine insertion variant in 5′UTR of edn1 gene has been reported to be associated with increased expression of Endothelin-1 in vitro. The aim of present study was to explore the association of this variant with the circulating levels of Endothelin-1 in vivo using archived DNA and plasma samples from 38 paediatric congenital heart disease (cyanotic and acyanotic) patients with severe pulmonary hypertension. Results The plasma Endothelin-1 levels were highly varied ranging from 1.63 to75.16 pg/ml. The + 139 ‘A’ insertion variant in 5′UTR of edn1 was seen in 8 out of 38 cases with only one acyanotic sample demonstrating homozygosity of inserted ‘A’ allele at + 139 site (4A/4A genotype). The plasma Endothelin-1 levels in children with homozygous variant 3A/3A genotype were comparable in cyanotic and acyanotic groups. Lone 4A/4A acyanotic sample had ET-1 levels similar to the median value of ET-1 associated with 3A/3A genotype and was absent in cyanotic group presumably due to deleterious higher ET-1 levels. The discussed observations, limited by the small sample size, are suggestive of homozygous adenine insertion variant posing a risk in cyanotic babies with Severe Pulmonary Hypertension.

scholarly journals In-vivo assessment of in-vitro killing patterns of Pseudomonas aeruginosa

1985 ◽  
Vol 15 (suppl A) ◽  
pp. 201-206 ◽  
Author(s):  
A. U. Gerber ◽  
C. Feller-Segessenmann
Keyword(s):  
Pseudomonas Aeruginosa ◽  
In Vivo Assessment

scholarly journals Toxicity of citrate-capped AuNPs: an in vitro and in vivo assessment

2011 ◽  
Vol 13 (12) ◽  
pp. 6821-6835 ◽  
Author(s):  
Stefania Sabella ◽  
Virgilio Brunetti ◽  
Giuseppe Vecchio ◽  
Antonio Galeone ◽  
Gabriele Maiorano ◽  
...  
Keyword(s):  
In Vivo Assessment

In Vitro and In Vivo Assessment of Renal Drug Transporters in the Disposition of Mesna and Dimesna

2012 ◽  
Vol 52 (4) ◽  
pp. 530-542 ◽  
Author(s):  
M. J. Cutler ◽  
B. L. Urquhart ◽  
T. J. Velenosi ◽  
H. E. Meyer zu Schwabedissen ◽  
G. K. Dresser ◽  
...  
Keyword(s):  
Drug Transporters ◽  
In Vivo Assessment
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