Lipoplexes Targeting the CD44 Hyaluronic Acid Receptor for Efficient Transfection of Breast Cancer Cells

2009 ◽  
Vol 6 (4) ◽  
pp. 1062-1073 ◽  
Author(s):  
Claudio Surace ◽  
Silvia Arpicco ◽  
Amélie Dufaÿ-Wojcicki ◽  
Véronique Marsaud ◽  
Céline Bouclier ◽  
...  
2020 ◽  
Vol 107 ◽  
pp. 65-77 ◽  
Author(s):  
Akshay A. Narkhede ◽  
James H. Crenshaw ◽  
David K. Crossman ◽  
Lalita A. Shevde ◽  
Shreyas S. Rao

1995 ◽  
Vol 109 (1) ◽  
pp. 77-86 ◽  
Author(s):  
Bas-jan M. van der Leede ◽  
Gert E. Folkers ◽  
Christina E. van den Brink ◽  
Paul T. van der Saag ◽  
Bart van der Burg

Polymers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1094 ◽  
Author(s):  
Hsin-Ta Wang ◽  
Po-Chien Chou ◽  
Ping-Han Wu ◽  
Chi-Ming Lee ◽  
Kang-Hsin Fan ◽  
...  

Low-molecular-weight hyaluronic acid (LMWHA) was integrated with superparamagnetic Fe3O4 nanoparticles (Fe3O4 NPs). The size distribution, zeta potential, viscosity, thermogravimetric and paramagnetic properties of the LMWHA-Fe3O4 NPs were systematically examined. For cellular experiments, MCF7 breast cancer cell line was carried out. In addition, the cell targeting ability and characteristics of the LMWHA-Fe3O4 NPs for MCF7 breast cancer cells were analyzed using the thiocyanate method and time-of-flight secondary ion mass spectrometry (TOF-SIMS). The experimental results showed that the LMWHA-Fe3O4 NPs were not only easily injectable due to their low viscosity, but also exhibited a significant superparamagnetic property. Furthermore, the in vitro assay results showed that the NPs had negligible cytotoxicity and exhibited a good cancer cell targeting ability. Overall, the results therefore suggest that the LMWHA-Fe3O4 NPs have considerable potential as an injectable agent for enhanced magnetic resonance imaging (MRI) and/or hyperthermia treatment in breast cancer therapy.


RSC Advances ◽  
2016 ◽  
Vol 6 (45) ◽  
pp. 38624-38636 ◽  
Author(s):  
Tong An ◽  
Cong Zhang ◽  
Xue Han ◽  
Guoyun Wan ◽  
Dan Wang ◽  
...  

Hyaluronic acid-coated poly(β-amino) ester nanoparticles used as carrier for doxorubicin could efficiently overcome the drug resistance in breast cancer cells.


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