Inhibition of Bcr-Abl in Human Leukemic Cells with a Coiled-Coil Protein Delivered by a Leukemia-Specific Cell-Penetrating Peptide

2015 ◽  
Vol 12 (5) ◽  
pp. 1412-1421 ◽  
Author(s):  
Benjamin J. Bruno ◽  
Carol S. Lim
Keyword(s):  
Coiled Coil ◽  
Leukemic Cells ◽  
Cell Penetrating Peptide ◽  
Specific Cell ◽  
Cell Penetrating ◽  
Human Leukemic Cells

scholarly journals Designing and enhancing the antifungal activity of corneal specific cell penetrating peptide using gelatin hydrogel delivery system

2019 ◽  
Vol Volume 14 ◽  
pp. 605-622 ◽  
Author(s):  
Chatterjee Amit ◽  
Shalini Muralikumar ◽  
Sargunam Janaki ◽  
Meena Lakshmipathy ◽  
Kulandhai Lilly Therese ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Delivery System ◽  
Cell Penetrating Peptide ◽  
Specific Cell ◽  
Gelatin Hydrogel ◽  
Cell Penetrating

scholarly journals A Cancer Specific Cell-Penetrating Peptide, BR2, for the Efficient Delivery of an scFv into Cancer Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e66084 ◽  
Author(s):  
Ki Jung Lim ◽  
Bong Hyun Sung ◽  
Ju Ri Shin ◽  
Young Woong Lee ◽  
Da Jung Kim ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cell Penetrating Peptide ◽  
Specific Cell ◽  
Efficient Delivery ◽  
Cell Penetrating

scholarly journals Design and Screening of a Glial Cell-Specific, Cell Penetrating Peptide for Therapeutic Applications in Multiple Sclerosis

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e45501 ◽  
Author(s):  
Corey Heffernan ◽  
Huseyin Sumer ◽  
Gilles J. Guillemin ◽  
Ursula Manuelpillai ◽  
Paul J. Verma
Keyword(s):  
Multiple Sclerosis ◽  
Glial Cell ◽  
Cell Penetrating Peptide ◽  
Specific Cell ◽  
Therapeutic Applications ◽  
Cell Penetrating

VEGF siRNA Delivery by a Cancer-Specific Cell-Penetrating Peptide

2018 ◽  
Vol 28 (3) ◽  
pp. 367-374 ◽  
Author(s):  
Young Woong Lee ◽  
Young Eun Hwang ◽  
Ju Young Lee ◽  
Jung-Hoon Sohn ◽  
Bong Hyun Sung ◽  
...  
Keyword(s):  
Sirna Delivery ◽  
Cell Penetrating Peptide ◽  
Specific Cell ◽  
Cell Penetrating

A specific cell-penetrating peptide induces apoptosis in SKOV3 cells by down-regulation of Bcl-2

2013 ◽  
Vol 35 (11) ◽  
pp. 1791-1797 ◽  
Author(s):  
Chuying Ma ◽  
Guangfu Yin ◽  
Fei You ◽  
Yan Wei ◽  
Zhongbing Huang ◽  
...  
Keyword(s):  
Cell Penetrating Peptide ◽  
Specific Cell ◽  
Down Regulation ◽  
Skov3 Cells ◽  
Cell Penetrating

scholarly journals Dimerization of a cell-penetrating peptide leads to enhanced cellular uptake and drug delivery

2012 ◽  
Vol 8 ◽  
pp. 1788-1797 ◽  
Author(s):  
Jan Hoyer ◽  
Ulrich Schatzschneider ◽  
Michaela Schulz-Siegmund ◽  
Ines Neundorf
Keyword(s):  
Drug Delivery ◽  
Tumor Cells ◽  
Cell Lines ◽  
Cellular Uptake ◽  
Cell Penetrating Peptides ◽  
Antimicrobial Protein ◽  
Cell Penetrating Peptide ◽  
Specific Cell ◽  
Cell Penetrating ◽  
A Cell

Over the past 20 years, cell-penetrating peptides (CPPs) have gained tremendous interest due to their ability to deliver a variety of therapeutically active molecules that would otherwise be unable to cross the cellular membrane due to their size or hydrophilicity. Recently, we reported on the identification of a novel CPP, sC18, which is derived from the C-terminus of the 18 kDa cationic antimicrobial protein. Furthermore, we demonstrated successful application of sC18 for the delivery of functionalized cyclopentadienyl manganese tricarbonyl (cymantrene) complexes to tumor cell lines, inducing high cellular toxicity. In order to increase the potential of the organometallic complexes to kill tumor cells, we were looking for a way to enhance cellular uptake. Therefore, we designed a branched dimeric variant of sC18, (sC18)2, which was shown to have a dramatically improved capacity to internalize into various cell lines, even primary cells, using flow cytometry and fluorescence microscopy. Cell viability assays indicated increased cytotoxicity of the dimer presumably caused by membrane leakage; however, this effect turned out to be dependent on the specific cell type. Finally, we could show that conjugation of a functionalized cymantrene with (sC18)2leads to significant reduction of its IC50value in tumor cells compared to the respective sC18 conjugate, proving that dimerization is a useful method to increase the drug-delivery potential of a cell-penetrating peptide.

Sign in / Sign up

Export Citation Format

Share Document