Enhanced Photodynamic Therapy and Effective Elimination of Cancer Stem Cells Using Surfactant–Polymer Nanoparticles

2014 ◽  
Vol 11 (9) ◽  
pp. 3186-3195 ◽  
Author(s):  
Marina Usacheva ◽  
Suresh Kumar Swaminathan ◽  
Ameya R. Kirtane ◽  
Jayanth Panyam
Keyword(s):  
Stem Cells ◽  
Photodynamic Therapy ◽  
Cancer Stem Cells ◽  
Polymer Nanoparticles

scholarly journals Effective Gold Nanoparticle-Antibody-Mediated Drug Delivery for Photodynamic Therapy of Lung Cancer Stem Cells

2020 ◽  
Vol 21 (11) ◽  
pp. 3742
Author(s):  
Anine Crous ◽  
Heidi Abrahamse
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Stem Cells ◽  
Cell Death ◽  
Photodynamic Therapy ◽  
Cancer Stem Cells ◽  
Lung Cancer Mortality ◽  
Drug Induced ◽  
Biochemical Assays ◽  
Lung Cancer Stem Cells

Cancer stem cells (CSCs) are a leading contributor to lung cancer mortality rates. CSCs are responsible for tumor growth and recurrence through inhibition of drug-induced cell death, decreasing the effect of traditional cancer therapy and photodynamic therapy (PDT). PDT can be improved to successfully treat lung cancer by using gold nanoparticles (AuNPs), due to their size and shape, which have been shown to facilitate drug delivery and retention, along with the targeted antibody (Ab) mediated selection of CSCs. In this study, a nanobioconjugate (NBC) was constructed, using a photosensitizer (PS) (AlPcS4Cl), AuNPs and Abs. The NBC was characterized, using spectroscopy techniques. Photodynamic effects of the NBC on lung CSCs was evaluated, using biochemical assays 24 h post-irradiation, in order to establish its anticancer effect. Results showed successful conjugation of the nanocomposite. Localization of the NBC was seen to be in integral organelles involved in cell homeostasis. Biochemical responses of lung CSCs treated using AlPcS4Cl-AuNP and AlPcS4Cl-AuNP-Ab showed significant cell toxicity and cell death, compared to free AlPcS4Cl. The PDT effects were enhanced when using the NBC, showing significant lung CSC destruction to the point of eradication.

scholarly journals Selective Targeting of Cancer Stem Cells (CSCs) Based on Photodynamic Therapy (PDT) Penetration Depth Inhibits Colon Polyp Formation in Mice

Cancers ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 203 ◽  
Author(s):  
Jun Ki Kim ◽  
Mi Ran Byun ◽  
Chi Hoon Maeng ◽  
Yi Rang Kim ◽  
Jin Woo Choi
Keyword(s):  
Stem Cells ◽  
Colon Cancer ◽  
Photodynamic Therapy ◽  
Cancer Stem Cells ◽  
Fluorescent Protein ◽  
Cancer Therapies ◽  
Therapy Technique ◽  
Selective Targeting ◽  
High Risk Populations ◽  
Green Fluorescent

Targeting cancer stem cells (CSCs) without damaging normal stem cells could contribute to the development of novel radical cancer therapies. Cells expressing leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) constitute a cancer-causing population in the colon; therefore, targeting of Lgr5+ cells is expected to provide an opportunity to mitigate colon cancer. However, the expression of Lgr5 in normal stem cells makes it difficult to prove the efficacy of therapies targeted exclusively at Lgr5+ cancer cells. We used a modified photodynamic therapy technique involving cellular radiative transfer between green fluorescent protein (GFP)-expressing cells and a rose bengal photosensitizer. After treatment, tumors containing GFP-Lgr5+ cells were observed to be significantly suppressed or retarded with little effect on GFP-Lgr5+ stem cells at the crypt bottom. Lgr5+ CSCs were specifically eradicated in situ, when localized based on the depth from the colon lumen, revealing the potential preventive efficacy of Lgr5-targeted therapy on tumor growth. This study supports the idea that Lgr5+ cells localized near the colon luminal surface are central to colorectal cancer. With further development, the targeting of localized Lgr5+ cancer stem cells, which this study demonstrates in concept, may be feasible for prevention of colon cancer in high-risk populations.

CD133 peptide-conjugated pyropheophorbide-a as a novel photosensitizer for targeted photodynamic therapy in colorectal cancer stem cells

2021 ◽  
Author(s):  
Shichao Yan ◽  
Da Tang ◽  
Zhangyong Hong ◽  
Jing Wang ◽  
Hui Yao ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cells ◽  
Photodynamic Therapy ◽  
Cancer Stem Cells ◽  
Malignant Tumor ◽  
The Third ◽  
The World ◽  
Pyropheophorbide A ◽  
Colorectal Cancer Stem Cells ◽  
Targeted Photodynamic Therapy

Colorectal cancer (CRC) is the third most common malignant tumor around the world. Recent findings suggest that cancer stem cells (CSCs) exert a pivotal role in the resistance to current...

scholarly journals Lovastatin Inhibits Cancer Stem Cells and Sensitizes to Chemo- and Photodynamic Therapy in Nasopharyngeal Carcinoma

2017 ◽  
Vol 8 (9) ◽  
pp. 1655-1664 ◽  
Author(s):  
Yikun Peng ◽  
Guangchun He ◽  
Da Tang ◽  
Li Xiong ◽  
Yu Wen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Photodynamic Therapy ◽  
Nasopharyngeal Carcinoma ◽  
Cancer Stem Cells

Nano-curcumin influences blue light photodynamic therapy for restraining glioblastoma stem cells growth

RSC Advances ◽  
2016 ◽  
Vol 6 (97) ◽  
pp. 95165-95168 ◽  
Author(s):  
A. Dev ◽  
A. K. Srivastava ◽  
S. Roy Choudhury ◽  
S. Karmakar
Keyword(s):  
Stem Cells ◽  
Photodynamic Therapy ◽  
Cancer Stem Cells ◽  
Blue Light ◽  
Therapeutic Potential ◽  
Glioblastoma Stem Cells

Nano-curcumin based blue light photodynamic therapy has therapeutic potential in the arsenal of glioblastoma cancer stem cells recurrence.

scholarly journals Photodynamic therapy regulates fate of cancer stem cells through reactive oxygen species

2020 ◽  
Vol 12 (7) ◽  
pp. 562-584 ◽  
Author(s):  
Zi-Jian Zhang ◽  
Kun-Peng Wang ◽  
Jing-Gang Mo ◽  
Li Xiong ◽  
Yu Wen
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cells ◽  
Photodynamic Therapy ◽  
Cancer Stem Cells ◽  
Reactive Oxygen ◽  
Oxygen Species

Hybrid system {W6I8}-cluster/dsDNA as an agent for targeted X-ray induced photodynamic therapy of cancer stem cells

2021 ◽  
Author(s):  
Tatyana Pozmogova ◽  
Natalya A. Sitnikova ◽  
Ekaterina V. Pronina ◽  
Svetlana M. Svetlana M. Miroshnichenko ◽  
Andrey O. Kushnarenko ◽  
...  
Keyword(s):  
Stem Cells ◽  
Photodynamic Therapy ◽  
Cancer Stem Cells ◽  
Hybrid System ◽  
High Mortality ◽  
Hierarchical Model ◽  
X Ray ◽  
Photodynamic Therapy Of Cancer ◽  
Tumour Formation

Metastasis is one of the leading causes of the recurrence and high mortality of cancer. According to a recent hierarchical model of tumour formation, cancer stem cells (CSCs) are responsible...

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