scholarly journals Validating Antimetastatic Effects of Natural Products in an Engineered Microfluidic Platform Mimicking Tumor Microenvironment

2014 ◽  
Vol 11 (7) ◽  
pp. 2022-2029 ◽  
Author(s):  
Yiming Niu ◽  
Jing Bai ◽  
Roger D. Kamm ◽  
Yitao Wang ◽  
Chunming Wang
Keyword(s):  
Natural Products ◽  
Tumor Microenvironment ◽  
Microfluidic Platform

scholarly journals Biomimetic tumor microenvironment on a microfluidic platform

2013 ◽  
Vol 7 (1) ◽  
pp. 011501 ◽  
Author(s):  
Huipeng Ma ◽  
Hui Xu ◽  
Jianhua Qin
Keyword(s):  
Tumor Microenvironment ◽  
Microfluidic Platform

scholarly journals Biomimetic Model of Tumor Microenvironment on Microfluidic Platform

2017 ◽  
Vol 6 (15) ◽  
pp. 1700196 ◽  
Author(s):  
Minhwan Chung ◽  
Jungho Ahn ◽  
Kyungmin Son ◽  
Sudong Kim ◽  
Noo Li Jeon
Keyword(s):  
Tumor Microenvironment ◽  
Microfluidic Platform

scholarly journals Natural Products with Activity against Lung Cancer: A Review Focusing on the Tumor Microenvironment

2021 ◽  
Vol 22 (19) ◽  
pp. 10827
Author(s):  
Yue Yang ◽  
Ning Li ◽  
Tian-Ming Wang ◽  
Lei Di
Keyword(s):  
Lung Cancer ◽  
Natural Products ◽  
Tumor Microenvironment ◽  
Anticancer Agents ◽  
Antitumor Effects ◽  
Experimental Proof ◽  
Lung Cancers ◽  
Lung Cancer Patients ◽  
Epithelial Cancers ◽  
Underlying Mechanisms

Lung cancer is one of the most prevalent malignancies worldwide. Despite the undeniable progress in lung cancer research made over the past decade, it is still the leading cause of cancer-related deaths and continues to challenge scientists and researchers engaged in searching for therapeutics and drugs. The tumor microenvironment (TME) is recognized as one of the major hallmarks of epithelial cancers, including the majority of lung cancers, and is associated with tumorigenesis, progression, invasion, and metastasis. Targeting of the TME has received increasing attention in recent years. Natural products have historically made substantial contributions to pharmacotherapy, especially for cancer. In this review, we emphasize the role of the TME and summarize the experimental proof demonstrating the antitumor effects and underlying mechanisms of natural products that target the TME. We also review the effects of natural products used in combination with anticancer agents. Moreover, we highlight nanotechnology and other materials used to enhance the effects of natural products. Overall, our hope is that this review of these natural products will encourage more thoughts and ideas on therapeutic development to benefit lung cancer patients.

Abstract A049: Three-dimensional microfluidic platform mimicking the tumor microenvironment

2019 ◽  
Author(s):  
Andrea Pavesi ◽  
Siew Cheng Wong ◽  
Roger Kamm ◽  
Sharon Wei Ling Lee ◽  
Giulia Adirani
Keyword(s):  
Tumor Microenvironment ◽  
Three Dimensional ◽  
Microfluidic Platform
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