Predicting Protein Aggregation during Storage in Lyophilized Solids Using Solid State Amide Hydrogen/Deuterium Exchange with Mass Spectrometric Analysis (ssHDX-MS)

Balakrishnan S. Moorthy; Steven G. Schultz; Sherry G. Kim; Elizabeth M. Topp

doi:10.1021/mp500005v

Predicting Protein Aggregation during Storage in Lyophilized Solids Using Solid State Amide Hydrogen/Deuterium Exchange with Mass Spectrometric Analysis (ssHDX-MS)

Molecular Pharmaceutics ◽

10.1021/mp500005v ◽

2014 ◽

Vol 11 (6) ◽

pp. 1869-1879 ◽

Cited By ~ 30

Author(s):

Balakrishnan S. Moorthy ◽

Steven G. Schultz ◽

Sherry G. Kim ◽

Elizabeth M. Topp

Keyword(s):

Solid State ◽

Protein Aggregation ◽

Mass Spectrometric ◽

Deuterium Exchange ◽

Mass Spectrometric Analysis ◽

Spectrometric Analysis ◽

Hydrogen Deuterium Exchange ◽

Amide Hydrogen ◽

Hydrogen Deuterium

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Effects of Drying Process on an IgG1 Monoclonal Antibody Using Solid-State Hydrogen Deuterium Exchange with Mass Spectrometric Analysis (ssHDX-MS)

Pharmaceutical Research ◽

10.1007/s11095-017-2318-9 ◽

2018 ◽

Vol 35 (1) ◽

Cited By ~ 14

Author(s):

Ehab M. Moussa ◽

Nathan E. Wilson ◽

Qi Tony Zhou ◽

Satish K. Singh ◽

Sandeep Nema ◽

...

Keyword(s):

Monoclonal Antibody ◽

Solid State ◽

Mass Spectrometric ◽

Deuterium Exchange ◽

Mass Spectrometric Analysis ◽

Spectrometric Analysis ◽

Hydrogen Deuterium Exchange ◽

Drying Process ◽

Igg1 Monoclonal Antibody ◽

Hydrogen Deuterium

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Probing the Conformation of an IgG1 Monoclonal Antibody in Lyophilized Solids Using Solid-State Hydrogen–Deuterium Exchange with Mass Spectrometric Analysis (ssHDX-MS)

Molecular Pharmaceutics ◽

10.1021/acs.molpharmaceut.7b00696 ◽

2018 ◽

Vol 15 (2) ◽

pp. 356-368 ◽

Cited By ~ 6

Author(s):

Ehab M. Moussa ◽

Satish K. Singh ◽

Michael Kimmel ◽

Sandeep Nema ◽

Elizabeth M. Topp

Keyword(s):

Monoclonal Antibody ◽

Solid State ◽

Mass Spectrometric ◽

Deuterium Exchange ◽

Mass Spectrometric Analysis ◽

Spectrometric Analysis ◽

Hydrogen Deuterium Exchange ◽

Igg1 Monoclonal Antibody ◽

Hydrogen Deuterium

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Ion mobility adds an additional dimension to mass spectrometric analysis of solution-phase hydrogen/deuterium exchange

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.3688 ◽

2008 ◽

Vol 22 (18) ◽

pp. 2898-2904 ◽

Cited By ~ 49

Author(s):

Roxana E. Iacob ◽

James P. Murphy ◽

John R. Engen

Keyword(s):

Ion Mobility ◽

Mass Spectrometric ◽

Deuterium Exchange ◽

Mass Spectrometric Analysis ◽

Solution Phase ◽

Spectrometric Analysis ◽

Hydrogen Deuterium Exchange ◽

Additional Dimension ◽

Hydrogen Deuterium

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Supercritical Fluid Chromatography Reduction of Hydrogen/Deuterium Back Exchange in Solution-Phase Hydrogen/Deuterium Exchange with Mass Spectrometric Analysis

Analytical Chemistry ◽

10.1021/ac060693n ◽

2006 ◽

Vol 78 (19) ◽

pp. 7058-7060 ◽

Cited By ~ 25

Author(s):

Mark R. Emmett ◽

Sasa Kazazic ◽

Alan G. Marshall ◽

Wei Chen ◽

Stone D.-H. Shi ◽

...

Keyword(s):

Supercritical Fluid ◽

Supercritical Fluid Chromatography ◽

Mass Spectrometric ◽

Deuterium Exchange ◽

Mass Spectrometric Analysis ◽

Solution Phase ◽

Spectrometric Analysis ◽

Hydrogen Deuterium Exchange ◽

Back Exchange ◽

Hydrogen Deuterium

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Hydrogen/Deuterium Exchange Mass Spectrometric Analysis of Conformational Changes Accompanying the Assembly of the Yeast Prion Ure2p into Protein Fibrils

Journal of Molecular Biology ◽

10.1016/j.jmb.2007.04.018 ◽

2007 ◽

Vol 369 (4) ◽

pp. 1113-1125 ◽

Cited By ~ 15

Author(s):

Virginie Redeker ◽

Frédéric Halgand ◽

Jean-Pierre Le Caer ◽

Luc Bousset ◽

Olivier Laprévote ◽

...

Keyword(s):

Conformational Changes ◽

Mass Spectrometric ◽

Deuterium Exchange ◽

Mass Spectrometric Analysis ◽

Spectrometric Analysis ◽

Hydrogen Deuterium Exchange ◽

Yeast Prion ◽

Protein Fibrils ◽

Hydrogen Deuterium

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Faculty Opinions recommendation of Supercritical fluid chromatography reduction of hydrogen/deuterium back exchange in solution-phase hydrogen/deuterium exchange with mass spectrometric analysis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1046680.496680 ◽

2006 ◽

Author(s):

Stephen Eyles

Keyword(s):

Supercritical Fluid ◽

Supercritical Fluid Chromatography ◽

Mass Spectrometric ◽

Deuterium Exchange ◽

Mass Spectrometric Analysis ◽

Solution Phase ◽

Spectrometric Analysis ◽

Hydrogen Deuterium Exchange ◽

Back Exchange ◽

Hydrogen Deuterium

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Expansion of time window for mass spectrometric measurement of amide hydrogen/deuterium exchange reactions

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.4814 ◽

2010 ◽

Vol 24 (24) ◽

pp. 3585-3592 ◽

Cited By ~ 46

Author(s):

Stephen J. Coales ◽

Sook Yen E ◽

Jessica E. Lee ◽

Anita Ma ◽

Jeffrey A. Morrow ◽

...

Keyword(s):

Time Window ◽

Mass Spectrometric ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Amide Hydrogen ◽

Exchange Reactions ◽

Mass Spectrometric Measurement ◽

Spectrometric Measurement ◽

Hydrogen Deuterium

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Metabolite identification of artemether by data-dependent accurate mass spectrometric analysis using an LTQ-Orbitrap hybrid mass spectrometer in combination with the online hydrogen/deuterium exchange technique

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.5214 ◽

2011 ◽

Vol 25 (21) ◽

pp. 3303-3313 ◽

Cited By ~ 15

Author(s):

Tian Liu ◽

Fuying Du ◽

Fanping Zhu ◽

Jie Xing

Keyword(s):

Mass Spectrometer ◽

Metabolite Identification ◽

Mass Spectrometric ◽

Mass Spectrometric Analysis ◽

Accurate Mass ◽

Spectrometric Analysis ◽

Hydrogen Deuterium Exchange ◽

Hybrid Mass Spectrometer ◽

Hydrogen Deuterium ◽

Exchange Technique

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Faculty Opinions recommendation of Expansion of time window for mass spectrometric measurement of amide hydrogen/deuterium exchange reactions.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.6749956.6915054 ◽

2010 ◽

Author(s):

Stephen Eyles

Keyword(s):

Time Window ◽

Mass Spectrometric ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Amide Hydrogen ◽

Exchange Reactions ◽

Mass Spectrometric Measurement ◽

Spectrometric Measurement ◽

Hydrogen Deuterium

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Metabolite identification of triptolide by data-dependent accurate mass spectrometric analysis in combination with online hydrogen/deuterium exchange and multiple data-mining techniques

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.5211 ◽

2011 ◽

Vol 25 (20) ◽

pp. 3167-3177 ◽

Cited By ~ 18

Author(s):

Fuying Du ◽

Ting Liu ◽

Tian Liu ◽

Yongwei Wang ◽

Yakun Wan ◽

...

Keyword(s):

Data Mining ◽

Metabolite Identification ◽

Mass Spectrometric ◽

Mass Spectrometric Analysis ◽

Accurate Mass ◽

Spectrometric Analysis ◽

Hydrogen Deuterium Exchange ◽

Data Mining Techniques ◽

Multiple Data ◽

Hydrogen Deuterium

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