scholarly journals Interaction between Cell-Penetrating Peptides and Acid-Sensitive Anionic Oligopeptides as a Model for the Design of Targeted Drug Carriers

2014 ◽  
Vol 11 (5) ◽  
pp. 1583-1590 ◽  
Author(s):  
Chunmeng Sun ◽  
Wei-Chiang Shen ◽  
Jiasheng Tu ◽  
Jennica L. Zaro
Keyword(s):  
Drug Carriers ◽  
Cell Penetrating Peptides ◽  
Cell Penetrating ◽  
Targeted Drug

scholarly journals Recent Advances in Cell Penetrating Peptide-Based Anticancer Therapies

Molecules ◽  
2019 ◽  
Vol 24 (5) ◽  
pp. 927 ◽  
Author(s):  
Justine Habault ◽  
Jean-Luc Poyet
Keyword(s):  
Tissue Specificity ◽  
Chemical Compounds ◽  
Drug Carriers ◽  
Cell Penetrating Peptides ◽  
Amino Acid Sequences ◽  
Recent Advances ◽  
Cell Penetrating ◽  
A Cell ◽  
Low Toxicity ◽  
Applied Biology

Cell-penetrating-peptides (CPPs) are small amino-acid sequences characterized by their ability to cross cellular membranes. They can transport various bioactive cargos inside cells including nucleic acids, large proteins, and other chemical compounds. Since 1988, natural and synthetic CPPs have been developed for applications ranging from fundamental to applied biology (cell imaging, gene editing, therapeutics delivery). In recent years, a great number of studies reported the potential of CPPs as carriers for the treatment of various diseases. Apart from a good efficacy due to a rapid and potent delivery, a crucial advantage of CPP-based therapies is the peptides low toxicity compared to most drug carriers. On the other hand, they are quite unstable and lack specificity. Higher specificity can be obtained using a cell-specific CPP to transport the therapeutic agent or using a non-specific CPP to transport a cargo with a targeted activity. CPP-cargo complexes can also be conjugated to another moiety that brings cell- or tissue-specificity. Studies based on all these approaches are showing promising results. Here, we focus on recent advances in the potential usage of CPPs in the context of cancer therapy, with a particular interest in CPP-mediated delivery of anti-tumoral proteins.

Acid-Active Cell-Penetrating Peptides for in Vivo Tumor-Targeted Drug Delivery

2013 ◽  
Vol 135 (2) ◽  
pp. 933-940 ◽  
Author(s):  
Erlei Jin ◽  
Bo Zhang ◽  
Xuanrong Sun ◽  
Zhuxian Zhou ◽  
Xinpeng Ma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Cell Penetrating Peptides ◽  
Active Cell ◽  
Cell Penetrating ◽  
Targeted Drug
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