Charge-Conversional PEG-Polypeptide Polyionic Complex Nanoparticles from Simple Blending of a Pair of Oppositely Charged Block Copolymers as an Intelligent Vehicle for Efficient Antitumor Drug Delivery

2014 ◽  
Vol 11 (5) ◽  
pp. 1562-1574 ◽  
Author(s):  
Shixian Lv ◽  
Wantong Song ◽  
Zhaohui Tang ◽  
Mingqiang Li ◽  
Haiyang Yu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Antitumor Drug ◽  
Intelligent Vehicle ◽  
Oppositely Charged ◽  
Polyionic Complex

scholarly journals A review of nanotechnology with an emphasis on Nanoplex

2015 ◽  
Vol 51 (2) ◽  
pp. 255-263
Author(s):  
Rupali Nanasaheb Kadam ◽  
Raosaheb Sopanrao Shendge ◽  
Vishal Vijay Pande
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Drug Loading ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
X Ray ◽  
Conventional Drug ◽  
Anionic Drugs ◽  
Oppositely Charged ◽  
The Brain

<p>The use of nanotechnology based on the development and fabrication of nanostructures is one approach that has been employed to overcome the challenges involved with conventional drug delivery systems. Formulating Nanoplex is the new trend in nanotechnology. A nanoplex is a complex formed by a drug nanoparticle with an oppositely charged polyelectrolyte. Both cationic and anionic drugs form complexes with oppositely charged polyelectrolytes. Compared with other nanostructures, the yield of Nanoplex is greater and the complexation efficiency is better. Nanoplex are also easier to prepare. Nanoplex formulation is characterized through the production yield, complexation efficiency, drug loading, particle size and zeta potential using scanning electron microscopy, differential scanning calorimetry, X-ray diffraction and dialysis studies. Nanoplex have wide-ranging applications in different fields such as cancer therapy, gene drug delivery, drug delivery to the brain and protein and peptide drug delivery.</p>

scholarly journals Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances

2021 ◽  
Vol 9 (1) ◽  
pp. 38-50
Author(s):  
Hien Phan ◽  
Vincenzo Taresco ◽  
Jacques Penelle ◽  
Benoit Couturaud
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Amphiphilic Block Copolymers ◽  
Stimuli Responsive ◽  
Site Specific ◽  
On Demand ◽  
Redox Agents

Stimuli-responsive amphiphilic block copolymers obtained by PISA have emerged as promising nanocarriers for enhancing site-specific and on-demand drug release in response to a range of stimuli such as pH, redox agents, light or temperature.

Nanoparticles for Drug Delivery Prepared from Amphiphilic PLGA Zwitterionic Block Copolymers with Sharp Contrast in Polarity between Two Blocks

2010 ◽  
Vol 122 (22) ◽  
pp. 3859-3864 ◽  
Author(s):  
Zhiqiang Cao ◽  
Qiuming Yu ◽  
Hong Xue ◽  
Gang Cheng ◽  
Shaoyi Jiang
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Sharp Contrast

scholarly journals Nanochitosan: Commemorating the Metamorphosis of an ExoSkeletal Waste to a Versatile Nutraceutical

Nanomaterials ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 821
Author(s):  
Iyyakkannu Sivanesan ◽  
Manikandan Muthu ◽  
Judy Gopal ◽  
Nazim Hasan ◽  
Syed Kashif Ali ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Antitumor Drug ◽  
Organic Polymer ◽  
Clinical Settings ◽  
Future Perspectives ◽  
Research Focus ◽  
Nano Structures

Chitin (poly-N-acetyl-D-glucosamine) is the second (after cellulose) most abundant organic polymer. In its deacetylated form—chitosan—becomes a very interesting material for medical use. The chitosan nano-structures whose preparation is described in this article shows unique biomedical value. The preparation of nanochitosan, as well as the most vital biomedical applications (antitumor, drug delivery and other medical uses), have been discussed in this review. The challenges confronting the progress of nanochitosan from benchtop to bedside clinical settings have been evaluated. The need for inclusion of nano aspects into chitosan research, with improvisation from nanotechnological inputs has been prescribed for breaking down the limitations. Future perspectives of nanochitosan and the challenges facing nanochitosan applications and the areas needing research focus have been highlighted.

Polymeric topology and composition constrained polyether–polyester micelles for directional antitumor drug delivery

2013 ◽  
Vol 9 (11) ◽  
pp. 8875-8884 ◽  
Author(s):  
Di Li ◽  
Hai Sun ◽  
Jianxun Ding ◽  
Zhaohui Tang ◽  
Ying Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Antitumor Drug

Smart polymeric particle encapsulated gadolinium oxide and europium: theranostic probes for magnetic resonance/optical imaging and antitumor drug delivery

2016 ◽  
Vol 4 (6) ◽  
pp. 1100-1107 ◽  
Author(s):  
Ruiqing Liu ◽  
Shuang Liang ◽  
Cun Jiang ◽  
Li Zhang ◽  
Tianmeng Yuan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Optical Imaging ◽  
Emulsion Polymerization ◽  
Gadolinium Oxide ◽  
Antitumor Drug ◽  
Ph Responsive ◽  
Polymeric Particles ◽  
Polymeric Particle

Paramagnetic, luminescent, and temperature/pH-responsive polymeric particles with MR/optical imaging and antitumor drug delivery capability are prepared by emulsifier-free emulsion polymerization.

On-demand shape transformation of polymer vesicles via site-specific isomerization of hydrazone photoswitches in monodisperse hydrophobic oligomers

2021 ◽  
Author(s):  
Valene Wang ◽  
Jiwon Kim ◽  
Junyoung Kim ◽  
Seul Woo Lee ◽  
Kyoung Taek Kim
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Conformational Change ◽  
Self Assembly ◽  
Shape Control ◽  
Shape Transformation ◽  
Site Specific ◽  
On Demand ◽  
Polymer Vesicles

The shape control of nanostructures formed by the solution self-assembly of block copolymers is of significance for drug delivery. In particular, site-specific perturbation resulting in the conformational change of the...

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