Chemically Reducible Lipid Bilayer Coated Mesoporous Silica Nanoparticles Demonstrating Controlled Release and HeLa and Normal Mouse Liver Cell Biocompatibility and Cellular Internalization

2012 ◽  
Vol 9 (9) ◽  
pp. 2770-2777 ◽  
Author(s):  
Robert A. Roggers ◽  
Victor S.-Y. Lin ◽  
Brian G. Trewyn
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Liver Cell ◽  
Mouse Liver ◽  
Normal Mouse ◽  
Mesoporous Silica Nanoparticles ◽  
Cellular Internalization ◽  
Mouse Liver Cell ◽  
Cell Biocompatibility

P(VPBA-DMAEA) as a pH-sensitive nanovalve for mesoporous silica nanoparticles based controlled release

2015 ◽  
Vol 26 (10) ◽  
pp. 1203-1208 ◽  
Author(s):  
Yu-Jie Chang ◽  
Xi-Zhen Liu ◽  
Qing Zhao ◽  
Xiao-Hai Yang ◽  
Ke-Min Wang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Ph Sensitive

scholarly journals Ultrasound-mediated cavitation-enhanced extravasation of mesoporous silica nanoparticles for controlled-release drug delivery

2018 ◽  
Vol 340 ◽  
pp. 2-8 ◽  
Author(s):  
Juan L. Paris ◽  
Christophoros Mannaris ◽  
M. Victoria Cabañas ◽  
Robert Carlisle ◽  
Miguel Manzano ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Release Drug

scholarly journals Anions as Triggers in Controlled Release Protocols from Mesoporous Silica Nanoparticles Functionalized with Macrocyclic Copper(II) Complexes

2016 ◽  
Vol 22 (39) ◽  
pp. 13935-13945 ◽  
Author(s):  
Sameh El Sayed ◽  
Michele Milani ◽  
Chiara Milanese ◽  
Maurizio Licchelli ◽  
Ramón Martínez-Máñez ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles

Floating tablets from mesoporous silica nanoparticles

2014 ◽  
Vol 2 (47) ◽  
pp. 8298-8302 ◽  
Author(s):  
Prasanna Lakshmi Abbaraju ◽  
Anand kumar Meka ◽  
Siddharth Jambhrunkar ◽  
Jun Zhang ◽  
Chun Xu ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Dissolution Rate ◽  
Mesoporous Silica Nanoparticles ◽  
Floating Tablets

Floating tablets were prepared using hydrophobic (curcumin) and hydrophilic (captopril) drug loaded mesoporous silica nanoparticles respectively, leading to an improved dissolution rate of curcumin and controlled release for captopril.

scholarly journals Particle-Size-Dependent Delivery of Antitumoral miRNA Using Targeted Mesoporous Silica Nanoparticles

Pharmaceutics ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 505 ◽  
Author(s):  
Lisa Haddick ◽  
Wei Zhang ◽  
Sören Reinhard ◽  
Karin Möller ◽  
Hanna Engelke ◽  
...  
Keyword(s):  
Charged Particle ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Particle Surface ◽  
Growth Factor Receptor ◽  
Peptide Ligand ◽  
Cellular Internalization ◽  
Release Agent ◽  
Knock Down

Multifunctional core-shell mesoporous silica nanoparticles (MSN) were tailored in size ranging from 60 to 160 nm as delivery agents for antitumoral microRNA (miRNA). The positively charged particle core with a pore diameter of about 5 nm and a stellate pore morphology allowed for an internal, protective adsorption of the fragile miRNA cargo. A negatively charged particle surface enabled the association of a deliberately designed block copolymer with the MSN shell by charge-matching, simultaneously acting as a capping as well as endosomal release agent. Furthermore, the copolymer was functionalized with the peptide ligand GE11 targeting the epidermal growth factor receptor, EGFR. These multifunctional nanoparticles showed an enhanced uptake into EGFR-overexpressing T24 bladder cancer cells through receptor-mediated cellular internalization. A luciferase gene knock-down of up to 65% and additional antitumoral effects such as a decreased cell migration as well as changes in cell cycle were observed. We demonstrate that nanoparticles with a diameter of 160 nm show the fastest cellular internalization after a very short incubation time of 45 min and produce the highest level of gene knock-down.

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