Balancing the Pharmacokinetics and Pharmacodynamics of Interferon-α2b and Human Serum Albumin Fusion Protein by Proteolytic or Reductive Cleavage Increases Its in Vivo Therapeutic Efficacy

2012 ◽  
Vol 9 (3) ◽  
pp. 664-670 ◽  
Author(s):  
Hong Liang Zhao ◽  
Chong Xue ◽  
Ji Liang Du ◽  
Min Ren ◽  
Shan Xia ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Fusion Protein ◽  
Serum Albumin ◽  
Human Serum ◽  
Therapeutic Efficacy ◽  
Reductive Cleavage ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Interferon Α2b

Disruption ofPichia pastoris PMR1 gene decreases its folding capacity on human serum albumin and interferon-α2b fusion protein

Yeast ◽  
2008 ◽  
Vol 25 (4) ◽  
pp. 279-286 ◽  
Author(s):  
Hong Liang Zhao ◽  
Chong Xue ◽  
Yang Wang ◽  
Qing Fen Duan ◽  
Xiang Hua Xiong ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Fusion Protein ◽  
Serum Albumin ◽  
Human Serum ◽  
Interferon Α2b

Circumventing the heterogeneity and instability of human serum albumin-interferon-α2b fusion protein by altering its orientation

2007 ◽  
Vol 131 (3) ◽  
pp. 245-252 ◽  
Author(s):  
Hong Liang Zhao ◽  
Chong Xue ◽  
Yang Wang ◽  
Xian Yu Li ◽  
Xiang Hua Xiong ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Fusion Protein ◽  
Serum Albumin ◽  
Human Serum ◽  
Interferon Α2b

Increasing the homogeneity, stability and activity of human serum albumin and interferon-α2b fusion protein by linker engineering

2008 ◽  
Vol 61 (1) ◽  
pp. 73-77 ◽  
Author(s):  
Hong Liang Zhao ◽  
Xue Qin Yao ◽  
Chong Xue ◽  
Yang Wang ◽  
Xiang Hua Xiong ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Fusion Protein ◽  
Serum Albumin ◽  
Human Serum ◽  
Interferon Α2b

Pharmacokinetics and in vitro and in vivo anti-tumor response of an interleukin-2-human serum albumin fusion protein in mice

2004 ◽  
Vol 54 (6) ◽  
pp. 535-547 ◽  
Author(s):  
Robert J. Melder ◽  
Blaire L. Osborn ◽  
Todd Riccobene ◽  
Palanisamy Kanakaraj ◽  
Ping Wei ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Fusion Protein ◽  
Serum Albumin ◽  
Human Serum ◽  
Tumor Response ◽  
Interleukin 2

Long-Acting Human Serum Albumin-Thioredoxin Fusion Protein Suppresses Bleomycin-Induced Pulmonary Fibrosis Progression

2013 ◽  
Vol 345 (2) ◽  
pp. 271-283 ◽  
Author(s):  
Ryota Tanaka ◽  
Hiroshi Watanabe ◽  
Azusa Kodama ◽  
Victor Tuan Giam Chuang ◽  
Yu Ishima ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Pulmonary Fibrosis ◽  
Fusion Protein ◽  
Serum Albumin ◽  
Human Serum ◽  
Fibrosis Progression ◽  
Long Acting

In vitro and in vivo antitubercular activity of benzothiazinone-loaded human serum albumin nanocarriers designed for inhalation

2020 ◽  
Vol 328 ◽  
pp. 339-349 ◽  
Author(s):  
Ayasha Patel ◽  
Natalja Redinger ◽  
Adrian Richter ◽  
Arcadia Woods ◽  
Paul Robert Neumann ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Antitubercular Activity

An effective and safe treatment strategy for rheumatoid arthritis based on human serum albumin and Kolliphor® HS 15

Nanomedicine ◽  
2019 ◽  
Vol 14 (16) ◽  
pp. 2169-2187 ◽  
Author(s):  
Ting Gong ◽  
Pei Zhang ◽  
Caifeng Deng ◽  
Yu Xiao ◽  
Tao Gong ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Therapeutic Strategy ◽  
Inflammatory Cell ◽  
In Vivo Studies ◽  
Targeting Ability

Aim: We aimed to construct human serum albumin-Kolliphor® HS 15 nanoparticles (HSA-HS15 NPs) to overcome the limitations in targeted therapy for rheumatoid arthritis (RA) and enhance the safety of drug-loaded HSA NPs. Methodology: Celastrol (CLT)-loaded HSA-HS15 NPs were prepared and the properties were adequately investigated; the treatment effect were evaluated in RA rats; in vitro and in vivo studies were performed to explain the mechanism. Results: CLT-HSA-HS15 NPs had remarkable treatment ability and enhanced safety in the treatment of RA compared with free CLT and CLT-HSA NPs. Conclusion: HSA-HS15 NPs could be a safe and efficient therapeutic strategy for the treatment of RA, because of the inflammatory targeting ability of albumin, the added HS15 and ELVIS effect (extravasation through leaky vasculature followed by inflammatory cell-mediated sequestration) of nanoparticles.

Bioengineered Human Serum Albumin Fusion Protein as Target/Enzyme/pH Three-Stage Propulsive Drug Vehicle for Tumor Therapy

ACS Nano ◽  
2020 ◽  
Vol 14 (12) ◽  
pp. 17405-17418
Author(s):  
Mingyu Wang ◽  
Li Zhang ◽  
Yanfei Cai ◽  
Yang Yang ◽  
Lipeng Qiu ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Fusion Protein ◽  
Serum Albumin ◽  
Human Serum ◽  
Tumor Therapy ◽  
Drug Vehicle ◽  
Target Enzyme
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