Coaxial Electrospray Formulations for Improving Oral Absorption of a Poorly Water-Soluble Drug

2011 ◽  
Vol 8 (3) ◽  
pp. 807-813 ◽  
Author(s):  
Shaoling Zhang ◽  
Kohsaku Kawakami ◽  
Marina Yamamoto ◽  
Yoshie Masaoka ◽  
Makoto Kataoka ◽  
...  
Keyword(s):  
Oral Absorption ◽  
Water Soluble ◽  
Water Soluble Drug ◽  
Poorly Water Soluble ◽  
Coaxial Electrospray ◽  
Poorly Water Soluble Drug

Development of microparticles coated with poly-γ-glutamic acid to improve oral absorption of a poorly water-soluble drug

2019 ◽  
Vol 24 (8) ◽  
pp. 992-1001
Author(s):  
Yuri Ikeuchi-Takahashi ◽  
Yudai Shiokawa ◽  
Kazuki Sekita ◽  
Etsuo Yonemochi ◽  
Hiraku Onishi
Keyword(s):  
Glutamic Acid ◽  
Oral Absorption ◽  
Water Soluble ◽  
Water Soluble Drug ◽  
Poorly Water Soluble ◽  
Poorly Water Soluble Drug

Effect of Oil-in-Water Submicron Emulsion Surface Charge on Oral Absorption of a Poorly Water-Soluble Drug in Rats

Drug Delivery ◽  
2008 ◽  
Vol 15 (8) ◽  
pp. 503-514 ◽  
Author(s):  
Stéphanie Poullain-Termeau ◽  
Sylvie Crauste-Manciet ◽  
Denis Brossard ◽  
Saleh Muhamed ◽  
Georges Nicolaos ◽  
...  
Keyword(s):  
Surface Charge ◽  
Oral Absorption ◽  
Water Soluble ◽  
Water Soluble Drug ◽  
Oil In Water ◽  
Poorly Water Soluble ◽  
Submicron Emulsion ◽  
Poorly Water Soluble Drug

scholarly journals Influence of Particle Design on Oral Absorption of Poorly Water-Soluble Drug in a Silica Particle–Supercritical Fluid System

2011 ◽  
Vol 59 (6) ◽  
pp. 686-691 ◽  
Author(s):  
Hiroshi Miura ◽  
Makoto Kanebako ◽  
Hiroyuki Shirai ◽  
Hiroshi Nakao ◽  
Toshio Inagi ◽  
...  
Keyword(s):  
Supercritical Fluid ◽  
Silica Particle ◽  
Oral Absorption ◽  
Water Soluble ◽  
Fluid System ◽  
Water Soluble Drug ◽  
Poorly Water Soluble ◽  
Poorly Water Soluble Drug

scholarly journals Improved Oral Absorption of a Poorly Water-Soluble Drug, HO-221, by Wet-Bead Milling Producing Particles in Submicron Region.

1993 ◽  
Vol 41 (4) ◽  
pp. 737-740 ◽  
Author(s):  
Nobuo KONDO ◽  
Toru IWAO ◽  
Hirotoshi MASUDA ◽  
Kouichi YAMANOUCHI ◽  
Yoshiaki ISHIHARA ◽  
...  
Keyword(s):  
Oral Absorption ◽  
Water Soluble ◽  
Bead Milling ◽  
Water Soluble Drug ◽  
Poorly Water Soluble ◽  
Wet Bead Milling ◽  
Poorly Water Soluble Drug

NANO-SIZED SOLID DISPERSION OF A POORLY WATER-SOLUBLE DRUG

2012 ◽  
pp. 31-35
Author(s):  
Truong Dinh Thao Tran ◽  
Ha Lien Phuong Tran ◽  
Nghia Khanh Tran ◽  
Van Toi Vo
Keyword(s):  
Drug Release ◽  
Droplet Size ◽  
Solid Dispersion ◽  
Water Soluble ◽  
Drug Dissolution ◽  
Dissolution Enhancement ◽  
Particle Size Reduction ◽  
Water Soluble Drug ◽  
Poorly Water Soluble ◽  
Poorly Water Soluble Drug

Purposes: Aims of this study are dissolution enhancement of a poorly water-soluble drug by nano-sized solid dispersion and investigation of machenism of drug release from the solid dispersion. A drug for osteoporosis treatment was used as the model drug in the study. Methods: melting method was used to prepare the solid dispersion. Drug dissolution rate was investigated at pH 1.2 and pH 6.8. Drug crystallinity was studied using differential scanning calorimetric and powder X-ray diffraction. In addition, droplet size and contact angle of drug were determined to elucidate mechanism of drug release. Results: Drug dissolution from the solid dispersion was significantly increased at pH 1.2 and pH 6.8 as compared to pure drug. Drug crystallinity was changed to partially amorphous. Also dissolution enhancement of drug was due to the improved wettability. The droplet size of drug was in the scale of nano-size when solid dispersion was dispersed in dissolution media. Conclusions: nano-sized solid dispersion in this research was a successful preparation to enhance bioavailability of a poorly water-soluble drug by mechanisms of crystal changes, particle size reduction and increase of wet property.

Sign in / Sign up

Export Citation Format

Share Document