scholarly journals A Covalently Stabilized Lipid−Polycation−DNA (sLPD) Vector for Antisense Oligonucleotide Delivery

2011 ◽  
Vol 8 (3) ◽  
pp. 709-715 ◽  
Author(s):  
Xiaojuan Yang ◽  
Yong Peng ◽  
Bo Yu ◽  
Jianhua Yu ◽  
Chenguang Zhou ◽  
...  
Keyword(s):  
Antisense Oligonucleotide ◽  
Oligonucleotide Delivery

Targeted Lipid Nanoparticles for Antisense Oligonucleotide Delivery

2014 ◽  
Vol 15 (9) ◽  
pp. 847-855 ◽  
Author(s):  
Raquel Petrilli ◽  
Josimar Eloy ◽  
Juliana Marchetti ◽  
Renata Lopez ◽  
Robert Lee
Keyword(s):  
Antisense Oligonucleotide ◽  
Lipid Nanoparticles ◽  
Oligonucleotide Delivery

scholarly journals Ethylcellulose nanoparticles as a new “in vitro” transfection tool for antisense oligonucleotide delivery

2020 ◽  
Vol 229 ◽  
pp. 115451 ◽  
Author(s):  
S. Leitner ◽  
S. Grijalvo ◽  
C. Solans ◽  
R. Eritja ◽  
M.J. García-Celma ◽  
...  
Keyword(s):  
Antisense Oligonucleotide ◽  
Oligonucleotide Delivery ◽  
In Vitro Transfection

scholarly journals A Polyethylenimine-Linoleic Acid Conjugate for Antisense Oligonucleotide Delivery

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Jing Xie ◽  
Lesheng Teng ◽  
Zhaogang Yang ◽  
Chenguang Zhou ◽  
Yang Liu ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Ribonucleotide Reductase ◽  
Antisense Oligonucleotide ◽  
Cellular Internalization ◽  
Protein Levels ◽  
Gel Retardation Assay ◽  
Promising Agent ◽  
Acid Conjugate ◽  
Oligonucleotide Delivery ◽  
Specific Inhibitors

A novel antisense oligonucleotide (ASO) carrier, polyethylenimine conjugated to linoleic acid (PEI-LA), was synthesized and evaluated for delivery of LOR-2501 to tumor cells. LOR-2501 is an ASO targeting ribonucleotide reductase R1 subunit (RRM1). In this study, PEI-LA was synthesized by reacting PEI (Mw ~ 800) with linoleoyl chloride. Gel retardation assay showed complete complexation between PEI-LA and LOR-2501 at N/P ratio above 8. No significant cytotoxicity was observed with these complexes at the tested dosage levels. Interestingly, at N/P ratio of >6, levels of cellular uptake of PEI-LA/LOR-2501 were double that of PEI/LOR-2501 complexes of the same N/P ratio. PEI-LA/LOR-2501 induced downregulation of 64% and 70% of RRM1 at mRNA and protein levels, respectively. The highest transfection activity was shown by PEI-LA/LOR-2501 complexes at N/P ratio of 10. Finally, using pathway specific inhibitors, clathrin-mediated endocytosis was shown to be the principle mechanism of cellular internalization of these complexes. In conclusion, PEI-LA is a promising agent for the delivery of ASOs and warrants further investigation.

Tailor-made core-shell nanospheres for antisense oligonucleotide delivery: IV.Adsorption/release behaviour

2001 ◽  
Vol 12 (12) ◽  
pp. 1339-1357 ◽  
Author(s):  
Luisa Tondelli ◽  
Elisa Canto ◽  
Alessandra Pistagna ◽  
Stefano Buttò ◽  
Antonella Tripiciano ◽  
...  
Keyword(s):  
Antisense Oligonucleotide ◽  
Core Shell ◽  
Oligonucleotide Delivery

scholarly journals Magnetofection—A highly efficient tool for antisense oligonucleotide delivery in vitro and in vivo

2003 ◽  
Vol 7 (5) ◽  
pp. 700-710 ◽  
Author(s):  
Florian Krötz ◽  
Cor de Wit ◽  
Hae-Young Sohn ◽  
Stefan Zahler ◽  
Torsten Gloe ◽  
...  
Keyword(s):  
Antisense Oligonucleotide ◽  
Efficient Tool ◽  
Highly Efficient ◽  
Oligonucleotide Delivery

Click conjugated polymeric immuno-nanoparticles for targeted siRNA and antisense oligonucleotide delivery

Biomaterials ◽  
2013 ◽  
Vol 34 (33) ◽  
pp. 8408-8415 ◽  
Author(s):  
Dianna P.Y. Chan ◽  
Glen F. Deleavey ◽  
Shawn C. Owen ◽  
Masad J. Damha ◽  
Molly S. Shoichet
Keyword(s):  
Antisense Oligonucleotide ◽  
Oligonucleotide Delivery

An anionic long-circulating liposome that improves radioiodinated antisense oligonucleotide delivery in vitro and in vivo

2011 ◽  
Vol 31 (1) ◽  
pp. 20-28 ◽  
Author(s):  
Jiawei Xie ◽  
Chao Ma ◽  
Jizheng Lin ◽  
Guoming Wang ◽  
Anren Kuang ◽  
...  
Keyword(s):  
Antisense Oligonucleotide ◽  
Oligonucleotide Delivery
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