HPMA Copolymer-Bound Doxorubicin Induces Apoptosis in Human Ovarian Carcinoma Cells by a Fas-Independent Pathway

Alexander Malugin; Pavla Kopečková; Jindřich Kopeček

doi:10.1021/mp049967q

HPMA Copolymer-Bound Doxorubicin Induces Apoptosis in Human Ovarian Carcinoma Cells by a Fas-Independent Pathway

Molecular Pharmaceutics ◽

10.1021/mp049967q ◽

2004 ◽

Vol 1 (3) ◽

pp. 174-182 ◽

Cited By ~ 18

Author(s):

Alexander Malugin ◽

Pavla Kopečková ◽

Jindřich Kopeček

Keyword(s):

Ovarian Carcinoma ◽

Carcinoma Cells ◽

Hpma Copolymer ◽

Ovarian Carcinoma Cells ◽

Human Ovarian Carcinoma ◽

Human Ovarian Carcinoma Cells

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Synthesis of HPMA Copolymer Containing Adriamycin Bound via an Acid-Labile Spacer and its Activity toward Human Ovarian Carcinoma Cells

Journal of Bioactive and Compatible Polymers ◽

10.1177/088391159901400601 ◽

1999 ◽

Vol 14 (6) ◽

pp. 447-456 ◽

Cited By ~ 31

Author(s):

Won-Moon Choi ◽

Pavla Kopečková ◽

Tamara Minko ◽

Jindřich Kopeček

Keyword(s):

Ovarian Carcinoma ◽

Carcinoma Cells ◽

Hpma Copolymer ◽

Ovarian Carcinoma Cells ◽

Human Ovarian Carcinoma ◽

Acid Labile ◽

Human Ovarian Carcinoma Cells

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Subcellular trafficking of HPMA copolymer–Tat conjugates in human ovarian carcinoma cells

Journal of Controlled Release ◽

10.1016/s0168-3659(03)00213-x ◽

2003 ◽

Vol 91 (1-2) ◽

pp. 53-59 ◽

Cited By ~ 39

Author(s):

A Nori

Keyword(s):

Ovarian Carcinoma ◽

Carcinoma Cells ◽

Subcellular Trafficking ◽

Hpma Copolymer ◽

Ovarian Carcinoma Cells ◽

Human Ovarian Carcinoma ◽

Human Ovarian Carcinoma Cells

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Combination Chemotherapy and Photodynamic Therapy with Fab′ Fragment Targeted HPMA Copolymer Conjugates in Human Ovarian Carcinoma Cells

Molecular Pharmaceutics ◽

10.1021/mp800006e ◽

2008 ◽

Vol 5 (5) ◽

pp. 696-709 ◽

Cited By ~ 46

Author(s):

Jarunee Hongrapipat ◽

Pavla Kopečková ◽

Jihua Liu ◽

Sompol Prakongpan ◽

Jindřich Kopeček

Keyword(s):

Photodynamic Therapy ◽

Ovarian Carcinoma ◽

Combination Chemotherapy ◽

Carcinoma Cells ◽

Hpma Copolymer ◽

Fab Fragment ◽

Ovarian Carcinoma Cells ◽

Human Ovarian Carcinoma ◽

Hpma Copolymer Conjugates ◽

Human Ovarian Carcinoma Cells

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Chronic exposure of human ovarian carcinoma cells to free or HPMA copolymer-bound mesochlorin e6 does not induce P-glycoprotein-mediated multidrug resistance

Biomaterials ◽

10.1016/s0142-9612(00)00161-7 ◽

2000 ◽

Vol 21 (21) ◽

pp. 2203-2210 ◽

Cited By ~ 26

Author(s):

Monica Tijerina ◽

Kirk D Fowers ◽

Pavla Kopečková ◽

Jindrich Kopeček

Keyword(s):

Multidrug Resistance ◽

Ovarian Carcinoma ◽

Chronic Exposure ◽

Carcinoma Cells ◽

Hpma Copolymer ◽

Ovarian Carcinoma Cells ◽

P Glycoprotein ◽

Human Ovarian Carcinoma ◽

Human Ovarian Carcinoma Cells

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Mechanisms of Cytotoxicity in Human Ovarian Carcinoma Cells Exposed to Free Mce6 or HPMA Copolymer–Mce6 Conjugates¶

Photochemistry and Photobiology ◽

10.1562/0031-8655(2003)077<0645:mociho>2.0.co;2 ◽

2003 ◽

Vol 77 (6) ◽

pp. 645 ◽

Cited By ~ 17

Author(s):

Monica Tijerina ◽

Pavla Kope&cbreve;ková ◽

Jindŕich Kope&cbreve;ek

Keyword(s):

Ovarian Carcinoma ◽

Carcinoma Cells ◽

Hpma Copolymer ◽

Ovarian Carcinoma Cells ◽

Human Ovarian Carcinoma ◽

Human Ovarian Carcinoma Cells

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Time- and concentration-dependent apoptosis and necrosis induced by free and HPMA copolymer-bound doxorubicin in human ovarian carcinoma cells

Journal of Controlled Release ◽

10.1016/s0168-3659(00)00301-1 ◽

2000 ◽

Vol 69 (1) ◽

pp. 185-196 ◽

Cited By ~ 22

Author(s):

Marina Demoy ◽

Tamara Minko ◽

Pavla Kopečková ◽

Jindřich Kopeček

Keyword(s):

Ovarian Carcinoma ◽

Carcinoma Cells ◽

Hpma Copolymer ◽

Ovarian Carcinoma Cells ◽

Human Ovarian Carcinoma ◽

Apoptosis And Necrosis ◽

Human Ovarian Carcinoma Cells

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Combination cytotoxicity of backbone degradable HPMA copolymer gemcitabine and platinum conjugates toward human ovarian carcinoma cells

European Journal of Pharmaceutics and Biopharmaceutics ◽

10.1016/j.ejpb.2013.11.008 ◽

2014 ◽

Vol 87 (1) ◽

pp. 187-196 ◽

Cited By ~ 33

Author(s):

Acharaporn Duangjai ◽

Kui Luo ◽

Yan Zhou ◽

Jiyuan Yang ◽

Jindřich Kopeček

Keyword(s):

Ovarian Carcinoma ◽

Carcinoma Cells ◽

Hpma Copolymer ◽

Ovarian Carcinoma Cells ◽

Human Ovarian Carcinoma ◽

Human Ovarian Carcinoma Cells

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Mechanisms of Cytotoxicity in Human Ovarian Carcinoma Cells Exposed to Free Mce6 or HPMA Copolymer-Mce6 Conjugates¶

Photochemistry and Photobiology ◽

10.1562/0031-8655(2003)0770645mociho2.0.co2 ◽

2007 ◽

Vol 77 (6) ◽

pp. 645-652 ◽

Cited By ~ 1

Author(s):

Monica Tijerina ◽

Pavla Kopec̆ková ◽

Jindŕich Kopec̆ek

Keyword(s):

Ovarian Carcinoma ◽

Carcinoma Cells ◽

Hpma Copolymer ◽

Ovarian Carcinoma Cells ◽

Human Ovarian Carcinoma ◽

Human Ovarian Carcinoma Cells

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Preliminary evaluation of caspases-dependent apoptosis signaling pathways of free and HPMA copolymer-bound doxorubicin in human ovarian carcinoma cells

Journal of Controlled Release ◽

10.1016/s0168-3659(01)00220-6 ◽

2001 ◽

Vol 71 (3) ◽

pp. 227-237 ◽

Cited By ~ 36

Author(s):

Tamara Minko ◽

Pavla Kopečková ◽

Jindřich Kopeček

Keyword(s):

Ovarian Carcinoma ◽

Signaling Pathways ◽

Carcinoma Cells ◽

Preliminary Evaluation ◽

Hpma Copolymer ◽

Ovarian Carcinoma Cells ◽

Human Ovarian Carcinoma ◽

Human Ovarian Carcinoma Cells

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Urinary chorionic gonadotropin with mitogenic effects on human ovarian carcinoma cells

Acta Endocrinologica ◽

10.1530/acta.0.117s053 ◽

1988 ◽

Vol 117 (4_Suppl) ◽

pp. S53-S54

Author(s):

J. HOFMANN ◽

F. HÖLZEL ◽

R. HACKENBERG ◽

K.-D. SCHULZ

Keyword(s):

Ovarian Carcinoma ◽

Chorionic Gonadotropin ◽

Carcinoma Cells ◽

Ovarian Carcinoma Cells ◽

Human Ovarian Carcinoma ◽

Human Ovarian Carcinoma Cells

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