Synthesis and Pharmacological Evaluation of DHβE Analogues as Neuronal Nicotinic Acetylcholine Receptor Antagonists

Tue Heesgaard Jepsen; Anders A. Jensen; Mads Henrik Lund; Emil Glibstrup; Jesper Langgaard Kristensen

doi:10.1021/ml500094c

Synthesis and Pharmacological Evaluation of DHβE Analogues as Neuronal Nicotinic Acetylcholine Receptor Antagonists

ACS Medicinal Chemistry Letters ◽

10.1021/ml500094c ◽

2014 ◽

Vol 5 (7) ◽

pp. 766-770 ◽

Cited By ~ 15

Author(s):

Tue Heesgaard Jepsen ◽

Anders A. Jensen ◽

Mads Henrik Lund ◽

Emil Glibstrup ◽

Jesper Langgaard Kristensen

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Receptor Antagonists ◽

Nicotinic Acetylcholine ◽

Pharmacological Evaluation

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Design, Synthesis, and Biological Evaluation of Erythrina Alkaloid Analogues as Neuronal Nicotinic Acetylcholine Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm4013592 ◽

2013 ◽

Vol 56 (23) ◽

pp. 9673-9682 ◽

Cited By ~ 32

Author(s):

François Crestey ◽

Anders A. Jensen ◽

Morten Borch ◽

Jesper Tobias Andreasen ◽

Jacob Andersen ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Biological Evaluation ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Receptor Antagonists ◽

Nicotinic Acetylcholine ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Erythrina Alkaloid

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Recent developments in neuronal nicotinic acetylcholine receptor antagonists

Expert Opinion on Therapeutic Patents ◽

10.1517/13543776.10.10.1561 ◽

2000 ◽

Vol 10 (10) ◽

pp. 1561-1581 ◽

Cited By ~ 34

Author(s):

Linda P Dwoskin ◽

Rui Xu ◽

Joshua T Ayers ◽

Peter A Crooks

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Receptor Antagonists ◽

Nicotinic Acetylcholine ◽

Recent Developments

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Identification of polypeptides associated with a putative neuronal nicotinic acetylcholine receptor.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)33771-2 ◽

1982 ◽

Vol 257 (19) ◽

pp. 11390-11394

Author(s):

H Betz ◽

D Graham ◽

H Rehm

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine

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5371188 Neuronal nicotinic acetylcholine receptor compositions

Biotechnology Advances ◽

10.1016/0734-9750(96)84630-1 ◽

1995 ◽

Vol 13 (4) ◽

pp. 716

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine

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Genetic association analysis of tagging SNPs in alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes (CHRNA4 and CHRNB2) with schizophrenia in the Japanese population

Journal of Neural Transmission ◽

10.1007/s00702-008-0114-8 ◽

2008 ◽

Vol 115 (10) ◽

pp. 1457-1461 ◽

Cited By ~ 8

Author(s):

Taro Kishi ◽

Masashi Ikeda ◽

Tsuyoshi Kitajima ◽

Yoshio Yamanouchi ◽

Yoko Kinoshita ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Genetic Association ◽

Nicotinic Acetylcholine Receptor ◽

Association Analysis ◽

Japanese Population ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Genetic Association Analysis ◽

Nicotinic Acetylcholine

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Analysis of specificity of antibodies against synthetic fragments of different neuronal nicotinic acetylcholine receptor subunits

Biochemistry (Moscow) ◽

10.1134/s0006297906070078 ◽

2006 ◽

Vol 71 (7) ◽

pp. 749-758 ◽

Cited By ~ 7

Author(s):

I. V. Shelukhina ◽

E. V. Kryukova ◽

M. V. Skok ◽

E. Yu. Lykhmus ◽

M. N. Zhmak ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine

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Functional Properties of the Neuronal Nicotinic Acetylcholine Receptor β3 Promoter in the Developing Central Nervous System

Journal of Biological Chemistry ◽

10.1074/jbc.273.24.15131 ◽

1998 ◽

Vol 273 (24) ◽

pp. 15131-15137 ◽

Cited By ~ 11

Author(s):

Tomas Roztocil ◽

Lidia Matter-Sadzinski ◽

Marie Gomez ◽

Marc Ballivet ◽

Jean-Marc Matter

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Functional Properties ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine

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Glucocorticoid activation of the neuronal nicotinic acetylcholine receptor α7 subunit gene: involvement of transcription factor Egr-1

FEBS Letters ◽

10.1016/j.febslet.2004.04.049 ◽

2004 ◽

Vol 566 (1-3) ◽

pp. 247-250 ◽

Cited By ~ 19

Author(s):

Carmen Carrasco-Serrano ◽

Manuel Criado

Keyword(s):

Transcription Factor ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Subunit Gene ◽

Nicotinic Acetylcholine ◽

Α7 Subunit

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In Vitro Pharmacological Characterization of a Novel Selective α7 Neuronal Nicotinic Acetylcholine Receptor Agonist ABT-107

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.110.167072 ◽

2010 ◽

Vol 334 (3) ◽

pp. 863-874 ◽

Cited By ~ 40

Author(s):

John Malysz ◽

David J. Anderson ◽

Jens H. Grønlien ◽

Jianguo Ji ◽

William H. Bunnelle ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Agonist ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Pharmacological Characterization ◽

Nicotinic Acetylcholine

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Effects of α4β2 and α7 nicotinic acetylcholine receptor antagonists on place aversion induced by naloxone in single-dose morphine-treated rats

European Journal of Pharmacology ◽

10.1016/j.ejphar.2005.06.050 ◽

2005 ◽

Vol 519 (1-2) ◽

pp. 91-95 ◽

Cited By ~ 14

Author(s):

Seiki Motoshima ◽

Katsuya Suemaru ◽

Youichi Kawasaki ◽

Chunyu Jin ◽

Hiromu Kawasaki ◽

...

Keyword(s):

Single Dose ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Antagonists ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Place Aversion

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