Novel Bivalent Ligands for D2/D3 Dopamine Receptors: Significant Cooperative Gain in D2 Affinity and Potency

Sanjib Gogoi; Swati Biswas; Gyan Modi; Tamara Antonio; Maarten E. A. Reith; Aloke K. Dutta

doi:10.1021/ml3002117

Novel Bivalent Ligands for D2/D3 Dopamine Receptors: Significant Cooperative Gain in D2 Affinity and Potency

ACS Medicinal Chemistry Letters ◽

10.1021/ml3002117 ◽

2012 ◽

Vol 3 (12) ◽

pp. 991-996 ◽

Cited By ~ 20

Author(s):

Sanjib Gogoi ◽

Swati Biswas ◽

Gyan Modi ◽

Tamara Antonio ◽

Maarten E. A. Reith ◽

...

Keyword(s):

Dopamine Receptors ◽

Bivalent Ligands ◽

Cooperative Gain

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Agonistic and Antagonistic Bivalent Ligands for Serotonin and Dopamine Receptors Including their Transporters

Current Topics in Medicinal Chemistry ◽

10.2174/156802607779941297 ◽

2007 ◽

Vol 7 (4) ◽

pp. 347-353 ◽

Cited By ~ 16

Author(s):

Michael Decker ◽

Jochen Lehmann

Keyword(s):

Dopamine Receptors ◽

Bivalent Ligands

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Remission of Recurrent Cochlear Hydrops Associated With Bromocriptine Treatment for Macroprolactinoma

American Journal of Audiology ◽

10.1044/2019_aja-18-0191 ◽

2019 ◽

Vol 28 (3) ◽

pp. 548-552

Author(s):

Andro Košec ◽

Ivan Kruljac ◽

Jakov Ajduk

Keyword(s):

Dopamine Receptors ◽

Male Patient ◽

Endolymphatic Hydrops ◽

Young Male ◽

Oral Steroid ◽

Case Description ◽

Diuretic Treatment ◽

Potential Therapeutic Role ◽

Transient Improvement ◽

Systemic Glucocorticoids

Objective Current recommendations for cochlear hydrops treatment include systemic glucocorticoids and diuretics. Cochlear cells express dopamine receptors, although their role is unknown in the pathophysiology of cochlear hydrops. Case Description We report the case of remission of recurrent right-sided cochlear hydrops in a young male patient treated with bromocriptine due to pituitary macroprolactinoma. Transient improvement was observed after oral steroid and diuretic treatment, but cochlear hydrops recurred until the dose of bromocriptine was increased to 10 mg daily. Conclusion Bromocriptine may stimulate dopamine receptors in cochlear cells with potential therapeutic role in patients with cochlear hydrops. There are no widely accepted and effective treatments for endolymphatic hydrops, and identifying potential new and efficacious therapeutics is of high relevance.

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