scholarly journals Potassium Channel Modulators as Possible Treatment for Pain

2012 ◽  
Vol 3 (8) ◽  
pp. 608-609
Author(s):  
Ahmed F. Abdel-Magid
Keyword(s):  
Potassium Channel ◽  
Potassium Channel Modulators

scholarly journals Effect of Potassium Channel Modulators on Morphine Withdrawal in Mice

2010 ◽  
Vol 4 ◽  
pp. SART.S6211 ◽  
Author(s):  
Vikas Seth ◽  
Mushtaq Ahmad ◽  
Prerna Upadhyaya ◽  
Monika Sharma ◽  
Vijay Moghe
Keyword(s):  
Potassium Channel ◽  
Withdrawal Syndrome ◽  
Channel Blocker ◽  
Inhibitory Effect ◽  
Morphine Withdrawal ◽  
The Other ◽  
Opioid Antagonist ◽  
Potassium Channel Openers ◽  
Potassium Channel Modulators ◽  
Withdrawal Signs

The present study was conducted to investigate the effect of potassium channel openers and blockers on morphine withdrawal syndrome. Mice were rendered dependent on morphine by subcutaneous injection of morphine; four hours later, withdrawal was induced by using an opioid antagonist, naloxone. Mice were observed for 30 minutes for the withdrawal signs ie, the characteristic jumping, hyperactivity, urination and diarrhea. ATP-dependent potassium (K+ATP) channel modulators were injected intraperitoneally (i.p.) 30 minutes before the naloxone. It was found that a K+ATP channel opener, minoxidil (12.5–50 mg/kg i.p.), suppressed the morphine withdrawal significantly. On the other hand, the K+ATP channel blocker glibenclamide (12.5–50 mg/kg i.p.) caused a significant facilitation of the withdrawal. Glibenclamide was also found to abolish the minoxidil's inhibitory effect on morphine withdrawal. The study concludes that K+ATP channels play an important role in the genesis of morphine withdrawal and K+ATP channel openers could be useful in the management of opioid withdrawal. As morphine opens K+ATP channels in neurons, the channel openers possibly act by mimicking the effects of morphine on neuronal K+ currents.

Influence of potassium channel modulators on morphine state-dependent memory of passive avoidance

2004 ◽  
Vol 15 (2) ◽  
pp. 103-110 ◽  
Author(s):  
M. R. Zarrindast ◽  
M. R. Jafari ◽  
B. Shafaghi ◽  
B. Djahanguiri
Keyword(s):  
Potassium Channel ◽  
Passive Avoidance ◽  
State Dependent ◽  
Potassium Channel Modulators

Effect of potassium channel modulators on male sexual behavior

Life Sciences ◽  
1996 ◽  
Vol 60 (4-5) ◽  
pp. 263-267 ◽  
Author(s):  
A. Benelli ◽  
R. Arletti ◽  
R. Poggioli ◽  
E. Cavazzuti ◽  
M. Mameli ◽  
...  
Keyword(s):  
Sexual Behavior ◽  
Potassium Channel ◽  
Male Sexual Behavior ◽  
Potassium Channel Modulators

Molecular Determinants for the Activating/Blocking Actions of the 2H-1,4-Benzoxazine Derivatives, a Class of Potassium Channel Modulators Targeting the Skeletal Muscle KATP Channels

2008 ◽  
Vol 74 (1) ◽  
pp. 50-58 ◽  
Author(s):  
Domenico Tricarico ◽  
Antonietta Mele ◽  
Giulia Maria Camerino ◽  
Antonio Laghezza ◽  
Giuseppe Carbonara ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Potassium Channel ◽  
Katp Channels ◽  
Molecular Determinants ◽  
Potassium Channel Modulators

Effects of potassium channel modulators on myogenic spontaneous phasic contractile activity in human detrusor from neurogenic patients

2010 ◽  
Vol 108 (4) ◽  
pp. 604-611 ◽  
Author(s):  
Stephanie Oger ◽  
Delphine Behr-Roussel ◽  
Diane Gorny ◽  
Jacques Bernabé ◽  
Eva Comperat ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Contractile Activity ◽  
Potassium Channel Modulators ◽  
Human Detrusor
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