scholarly journals Study of Kaempferol Glycoside as an Insulin Mimic Reveals Glycon To Be the Key Active Structure

2010 ◽  
Vol 2 (1) ◽  
pp. 17-21 ◽  
Author(s):  
Kazuaki Yamasaki ◽  
Ryogo Hishiki ◽  
Eisuke Kato ◽  
Jun Kawabata
Keyword(s):  
Active Structure ◽  
Kaempferol Glycoside ◽  
Insulin Mimic

True Catalytically Active Structure in Mo–V-Based Mixed Oxide Catalysts for Selective Oxidation of Acrolein

ACS Catalysis ◽  
2021 ◽  
pp. 10294-10307
Author(s):  
Satoshi Ishikawa ◽  
Yudai Yamada ◽  
Naoki Kashio ◽  
Nagisa Noda ◽  
Kosuke Shimoda ◽  
...  
Keyword(s):  
Selective Oxidation ◽  
Mixed Oxide ◽  
Oxide Catalysts ◽  
Active Structure ◽  
Mixed Oxide Catalysts ◽  
Catalytically Active

Potential-driven surface active structure rearrangement over FeP@NC towards efficient electrocatalytic hydrogen evolution

2019 ◽  
Vol 21 (15) ◽  
pp. 7918-7923 ◽  
Author(s):  
Fumin Tang ◽  
Hui Su ◽  
Xu Zhao ◽  
Hui Zhang ◽  
Fengchun Hu ◽  
...  
Keyword(s):  
Hydrogen Evolution ◽  
Hydrogen Evolution Reaction ◽  
Active Structure ◽  
Structure Rearrangement ◽  
Surface Active

Understanding the variation of active structure during the hydrogen evolution reaction (HER) process is of great importance for aiding in the design of optimized electrocatalysts.

scholarly journals Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2288 ◽  
Author(s):  
Wijdan M. Dabeek ◽  
Melissa Ventura Marra
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Vegetable Intake ◽  
Cardiovascular Effects ◽  
Fruit And Vegetable Intake ◽  
Food Sources ◽  
Free Form ◽  
Kaempferol Glycoside ◽  
Plant Sources ◽  
Reduced Risk

Fruit and vegetable intake has been associated with a reduced risk of cardiovascular disease. Quercetin and kaempferol are among the most ubiquitous polyphenols in fruit and vegetables. Most of the quercetin and kaempferol in plants is attached to sugar moieties rather than in the free form. The types and attachments of sugars impact bioavailability, and thus bioactivity. This article aims to review the current literature on the bioavailability of quercetin and kaempferol from food sources and evaluate the potential cardiovascular effects in humans. Foods with the highest concentrations of quercetin and kaempferol in plants are not necessarily the most bioavailable sources. Glucoside conjugates which are found in onions appear to have the highest bioavailability in humans. The absorbed quercetin and kaempferol are rapidly metabolized in the liver and circulate as methyl, glucuronide, and sulfate metabolites. These metabolites can be measured in the blood and urine to assess bioactivity in human trials. The optimal effective dose of quercetin reported to have beneficial effect of lowering blood pressure and inflammation is 500 mg of the aglycone form. Few clinical studies have examined the potential cardiovascular effects of high intakes of quercetin- and kaempferol-rich plants. However, it is possible that a lower dosage from plant sources could be effective due to of its higher bioavailability compared to the aglycone form. Studies are needed to evaluate the potential cardiovascular benefits of plants rich in quercetin and kaempferol glycoside conjugates.

scholarly journals Active stiffening of mitral valve leaflets in the beating heart

2009 ◽  
Vol 296 (6) ◽  
pp. H1766-H1773 ◽  
Author(s):  
Akinobu Itoh ◽  
Gaurav Krishnamurthy ◽  
Julia C. Swanson ◽  
Daniel B. Ennis ◽  
Wolfgang Bothe ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Contractile Activity ◽  
Complex Function ◽  
Beating Heart ◽  
Therapeutic Approaches ◽  
Active Structure ◽  
Highly Active ◽  
Adaptive Capabilities ◽  
Β Receptor ◽  
Isovolumic Relaxation

The anterior leaflet of the mitral valve (MV), viewed traditionally as a passive membrane, is shown to be a highly active structure in the beating heart. Two types of leaflet contractile activity are demonstrated: 1) a brief twitch at the beginning of each beat (reflecting contraction of myocytes in the leaflet in communication with and excited by left atrial muscle) that is relaxed by midsystole and whose contractile activity is eliminated with β-receptor blockade and 2) sustained tone during isovolumic relaxation, insensitive to β-blockade, but doubled by stimulation of the neurally rich region of aortic-mitral continuity. These findings raise the possibility that these leaflets are neurally controlled tissues, with potentially adaptive capabilities to meet the changing physiological demands on the heart. They also provide a basis for a permanent paradigm shift from one viewing the leaflets as passive flaps to one viewing them as active tissues whose complex function and dysfunction must be taken into account when considering not only therapeutic approaches to MV disease, but even the definitions of MV disease itself.

scholarly journals Blue flower coloration of Corydalis ambigua requires ferric ion and kaempferol glycoside

2021 ◽  
Vol 85 (1) ◽  
pp. 61-68
Author(s):  
Kumi Yoshida ◽  
Takeya Oniduka ◽  
Kin-ichi Oyama ◽  
Tadao Kondo
Keyword(s):  
Emission Spectroscopy ◽  
Atomic Emission ◽  
Early Spring ◽  
Blue Flower ◽  
Ferric Ion ◽  
Ferric Ions ◽  
Kaempferol Glycoside ◽  
Cotton Effects ◽  
Blue Coloration ◽  
Exciton Type

Abstract Corydalis ambigua (Japanese name, Ezoengosaku) flowers bloom with blue to purplish petals in early spring in Hokkaido prefecture. In this study, a mechanism for blue petal coloration by ferric ions and keampferol glycoside was elucidated. Blue petals and cell sap exhibited similar visible (Vis) spectra, with λmax at approximately 600 nm and circular dichroism (CD) with positive exciton-type Cotton effects in the Vis region. Analysis of the organic components of the petals confirmed cyanidin 3-O-sambubioside and kaempferol 3-O-sambubioside as the major flavonoids. Mg, Al, and Fe were detected in petals using atomic emission spectroscopy. Color, Vis absorption, and CD consistent with those of blue petals were reproduced by mixing cyanidin 3-O-sambubioside, kaempferol 3-O-sambubioside, and Fe3+ in a buffered aqueous solution at pH 6.5. Both Fe3+ and flavonol were essential for blue coloration.

Robust adaptive control of a slewing active structure

1999 ◽  
Author(s):  
David G. Wilson ◽  
Gordon G. Parker ◽  
Gregory P. Starr ◽  
Rush D. Robinett III
Keyword(s):  
Adaptive Control ◽  
Robust Adaptive Control ◽  
Active Structure ◽  
Robust Adaptive

scholarly journals Thymic hormone-containing cells. V. Immunohistological detection of metallothionein within the cells bearing thymulin (a zinc-containing hormone) in human and mouse thymuses.

1984 ◽  
Vol 32 (9) ◽  
pp. 942-946 ◽  
Author(s):  
W Savino ◽  
P C Huang ◽  
A Corrigan ◽  
S Berrih ◽  
M Dardenne
Keyword(s):  
Epithelial Cells ◽  
Biologically Active ◽  
Thymic Epithelial Cells ◽  
Cell Organelles ◽  
Thymic Hormone ◽  
Double Labeling ◽  
Active Structure ◽  
Transitional Metals ◽  
Zinc Storage ◽  
High Binding Affinity

Using an immunofluorescence (IF) assay, the presence of metallothionein (MT) was investigated in sections of normal and pathologic human thymuses as well as in cultures of thymic epithelial cells. This protein, known to have a high binding affinity for class II B transitional metals, such as zinc, was detected in the epithelial component of the thymus. Moreover, double labeling experiments with the anti-MT and an anti-thymulin monoclonal antibody showed that all cells containing thymulin, a thymic hormone whose active structure is known to contain zinc, also exhibited large amounts of metallothionein. These results, together with the fact that zinc and thymulin have been detected in the same type of cell organelles, lead to the conclusion that the MT present in thymic epithelial cells might be involved in the mechanism of zinc storage in these cells, thus favoring the secretion of thymulin in its biologically active, zinc-containing form.

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