Evidence of a Novel Side Chain Structure in Regioregular Poly(3-alkylthiophenes)

1996 ◽  
Vol 29 (10) ◽  
pp. 3654-3656 ◽  
Author(s):  
T. J. Prosa ◽  
M. J. Winokur ◽  
R. D. McCullough
Keyword(s):  
Chain Structure ◽  
Side Chain ◽  
Regioregular Poly

scholarly journals Relationship of 25-hydroxyvitamin D3 side chain structure to biological activity.

1975 ◽  
Vol 250 (1) ◽  
pp. 226-230
Author(s):  
M F Holick ◽  
M Garabedian ◽  
H K Schnoes ◽  
H F DeLuca
Keyword(s):  
Biological Activity ◽  
Chain Structure ◽  
Side Chain ◽  
Relationship Of

scholarly journals Entropy driven chain effects on ligation chemistry

2015 ◽  
Vol 6 (2) ◽  
pp. 1061-1074 ◽  
Author(s):  
Kai Pahnke ◽  
Josef Brandt ◽  
Ganna Gryn'ova ◽  
Peter Lindner ◽  
Ralf Schweins ◽  
...  
Keyword(s):  
Building Block ◽  
Chain Structure ◽  
Step Change ◽  
Side Chain ◽  
On Demand ◽  
Bonding Systems ◽  
Intrinsic Stiffness

Entropic chain effects on dynamic bonding reactions are shown to enable the tuning of reaction equilibria not only by changing the mass of the reactants, but also by merely altering the building block side chain structure and thus the intrinsic stiffness. The findings enable a step change for the design of on-demand bonding systems and reversible ligation chemistry in general.

Nanostructure Control of a Regioregular Poly(3-alkylthiophene) Using an Oligopeptide Side Chain

2020 ◽  
Vol 53 (14) ◽  
pp. 6087-6098
Author(s):  
Samuel Mirie Njenga ◽  
Xiao Wang ◽  
Wei Jiang ◽  
Xiaobo Wan
Keyword(s):  
Side Chain ◽  
Regioregular Poly ◽  
Nanostructure Control

scholarly journals Cephalosporins’ Cross-Reactivity and the High Degree of Required Knowledge. Case Report and Review of the Literature

Antibiotics ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 209
Author(s):  
Stefano D’Errico ◽  
Paola Frati ◽  
Martina Zanon ◽  
Eleonora Valentinuz ◽  
Federico Manetti ◽  
...  
Keyword(s):  
Present Report ◽  
Specific Ige ◽  
Chain Structure ◽  
Cross Reactivity ◽  
Side Chain ◽  
Mast Cell Tryptase ◽  
Immunohistochemical Examination ◽  
Femoral Blood ◽  
The Subject ◽  
High Degree

Antibiotic cross-reactivity represents a phenomenon of considerable interest as well as antibiotic resistance. Immediate reactions to cephalosporins are reported in the literature with a prevalence of only 1–3% of the population, while anaphylactic reactions are rarely described (approximately 0.0001–0.1%) as well as fatalities. Allergic reaction to cephalosporins may occur because of sensitization to unique cephalosporin haptens or to determinants shared with penicillins. Cross-reactivity between cephalosporins represents, in fact, a well-known threatening event involving cephalosporins with similar or identical R1- or R2-side chains. The present report describes the case of a 79-year-old man who suddenly died after intramuscular administration of ceftriaxone. Serum dosage of mast cell tryptase from a femoral blood sample at 3 and 24 h detected values of 87.7μg/L and 93.5μg/L, respectively (cut-off value 44.3 μg/L); the serum-specific IgE for penicillins, amoxicillin, cephaclor and also for the most common allergens were also determined. A complete post-mortem examination was performed, including gross, histological and immunohistochemical examination, with an anti-tryptase antibody. The cause of death was identified as anaphylactic shock: past administrations of cefepime sensitized the subject to cephalosporins and a fatal cross-reactivity of ceftriaxone with cefepime occurred due to the identical seven-position side chain structure in both molecules. The reported case offers food for thought regarding the study of cross-reactivity and the need to clarify the predictability and preventability of the phenomenon in fatal events.

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