Preparation of New α-Hydroxy Acids Derived from Amino Acids and Their Corresponding Polyesters

2008 ◽  
Vol 41 (20) ◽  
pp. 7259-7263 ◽  
Author(s):  
Naomi Cohen-Arazi ◽  
Jeoshua Katzhendler ◽  
Michal Kolitz ◽  
Abraham J. Domb
Keyword(s):  
Amino Acids ◽  
Hydroxy Acids

Chirality Sensing of Amines, Diamines, Amino Acids, Amino Alcohols, and α-Hydroxy Acids with a Single Probe

2013 ◽  
Vol 135 (48) ◽  
pp. 18052-18055 ◽  
Author(s):  
Keith W. Bentley ◽  
Yea G. Nam ◽  
Jaslynn M. Murphy ◽  
Christian Wolf
Keyword(s):  
Amino Acids ◽  
Amino Alcohols ◽  
Hydroxy Acids ◽  
Single Probe

Biodegradable Polymers Derived from Amino Acids for Biological Applications

2010 ◽  
Vol 76 ◽  
pp. 30-35 ◽  
Author(s):  
Naomi Cohen-Arazi ◽  
Ilanit Hagag ◽  
Michal Kolitz ◽  
Abraham J. Domb ◽  
Jeoshua Katzhendler
Keyword(s):  
Amino Acids ◽  
Molecular Weight ◽  
Ring Opening ◽  
Building Blocks ◽  
Ring Opening Polymerization ◽  
Microwave Assisted Synthesis ◽  
Hydroxy Acids ◽  
Natural Amino Acids ◽  
Direct Condensation ◽  
Positively Charged

Optically active α-hydroxy acids derived from amino acids have been synthesized and polymerized into new biodegradable polyesters. The variety of functional side chains enables the design of positively charged, negatively charged, hydrophobic and hydrophilic chiral building blocks or any combination of these constituents. Hydroxy acids of 15 natural amino acids were prepared with retention of configuration using a straightforward and reliable method of diazotization of α-amino acids. Polyesters were synthesized from these hydroxy acids by a number of methods: direct condensation in bulk, microwave assisted synthesis and ring opening polymerization. The molecular weight of the prepared polymers ranges between 2000 to 5000Da for the direct condensation and the microwave methods, whereas the ring opening polymerization results in high molecular weight polymers (20000 to 30000Da). The polymers were analyzed for their optical activity (Circular Dichroism Spectroscopy), thermal properties (DSC), solubility, molecular weight and polydispersity (GPC), and aqueous degradation. These polymers were tested for their compatibility to neuronal cells growth and differentiation.

Chiroptical sensing of unprotected amino acids, hydroxy acids, amino alcohols, amines and carboxylic acids with metal salts

2019 ◽  
Vol 55 (44) ◽  
pp. 6297-6300 ◽  
Author(s):  
Ciarán C. Lynch ◽  
Zeus A. De los Santos ◽  
Christian Wolf
Keyword(s):  
Amino Acids ◽  
Carboxylic Acids ◽  
Amino Alcohols ◽  
Metal Salts ◽  
Hydroxy Acids ◽  
Optical Chirality ◽  
Iron Palladium

Optical chirality sensing of unprotected amino acids, hydroxy acids, amino alcohols, amines and carboxylic acids based on a practical mix-and-measure protocol with readily available copper, iron, palladium, manganese, cerium or rhodium salts is demonstrated.

531. Effects of γ-radiation. Part I. Polymer formation from sugars, hydroxy-acids, and amino-acids

1959 ◽  
Vol 0 (0) ◽  
pp. 2648-2654 ◽  
Author(s):  
S. A. Barker ◽  
P. M. Grant ◽  
M. Stacey ◽  
R. B. Ward
Keyword(s):  
Amino Acids ◽  
Hydroxy Acids ◽  
Γ Radiation ◽  
Polymer Formation

Observations on the Elimination of Water from 2-Hydroxy Acids in the Metabolism of Amino Acids byClostridium sporogenes

1985 ◽  
Vol 366 (2) ◽  
pp. 1057-1062 ◽  
Author(s):  
Christa MACHACEK-PITSCH ◽  
Peter RAUSCHENBACH ◽  
Helmut SIMON
Keyword(s):  
Amino Acids ◽  
Hydroxy Acids

Oxidation of .alpha.-amino acids and .alpha.-hydroxy acids by Fremy's salt. A model for oxidases?

1986 ◽  
Vol 51 (22) ◽  
pp. 4285-4287 ◽  
Author(s):  
Angel Garcia-Raso ◽  
Pedro M. Deya ◽  
Jose M. Saa
Keyword(s):  
Amino Acids ◽  
Hydroxy Acids ◽  
Alpha Hydroxy Acids
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