Theory of Block Polymer Micelles: Recent Advances and Current Challenges

2012 ◽  
Vol 45 (11) ◽  
pp. 4429-4440 ◽  
Author(s):  
E. B. Zhulina ◽  
O. V. Borisov
Keyword(s):  
Polymer Micelles ◽  
Block Polymer ◽  
Recent Advances

Cross-linking polymerization-induced self-assembly to produce branched core cross-linked star block polymer micelles

2020 ◽  
Vol 11 (26) ◽  
pp. 4335-4343 ◽  
Author(s):  
Jongmin Park ◽  
Nam Young Ahn ◽  
Myungeun Seo
Keyword(s):  
Self Assembly ◽  
Cross Linking ◽  
Polymer Micelles ◽  
Block Polymer ◽  
Cross Linker

Copolymerizing a cross-linker in the PISA process spontaneously produces branched core cross-linked block polymer micelles.

Core hyper-cross-linked star polymers from block polymer micelle precursors

2020 ◽  
Vol 11 (45) ◽  
pp. 7178-7184
Author(s):  
Jongmin Park ◽  
Stefan J. D. Smith ◽  
Colin D. Wood ◽  
Xavier Mulet ◽  
Myungeun Seo
Keyword(s):  
Star Polymers ◽  
Cross Linking ◽  
Polymer Micelle ◽  
Polymer Micelles ◽  
Block Polymer

Hyper-cross-linking of a core of block polymer micelles produces core cross-linked polymer with a spacious hyper-cross-linked core, which is solution-processible.

Release Kinetics Studies of Aromatic Molecules into Water from Block Polymer Micelles

1998 ◽  
Vol 31 (11) ◽  
pp. 3578-3587 ◽  
Author(s):  
Yue Teng ◽  
M. E. Morrison ◽  
P. Munk ◽  
S. E. Webber ◽  
Karel Procházka
Keyword(s):  
Release Kinetics ◽  
Polymer Micelles ◽  
Block Polymer ◽  
Aromatic Molecules ◽  
Kinetics Studies

Block Polymer Micelles Enable CRISPR/Cas9 Ribonucleoprotein Delivery: Physicochemical Properties Affect Packaging Mechanisms and Gene Editing Efficiency

2019 ◽  
Vol 52 (21) ◽  
pp. 8197-8206 ◽  
Author(s):  
Zhe Tan ◽  
Yaming Jiang ◽  
Mitra S. Ganewatta ◽  
Ramya Kumar ◽  
Allison Keith ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Gene Editing ◽  
Polymer Micelles ◽  
Block Polymer ◽  
Editing Efficiency

pH-induced outward movement of star centers within coumarin-centered star-block polymer micelles

2012 ◽  
Vol 48 (88) ◽  
pp. 10883 ◽  
Author(s):  
Jinqiang Jiang ◽  
Yan Liu ◽  
Yunhua Gong ◽  
Qiaozhen Shu ◽  
Ming Yin ◽  
...  
Keyword(s):  
Polymer Micelles ◽  
Block Polymer

scholarly journals Micelle-Forming Block Copolymers Tailored for Inhibition of P-gp-Mediated Multidrug Resistance: Structure to Activity Relationship

Pharmaceutics ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 579 ◽  
Author(s):  
Braunová ◽  
Kaňa ◽  
Kudláčová ◽  
Kostka ◽  
Bouček ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Block Copolymers ◽  
Drug Carriers ◽  
Biological Properties ◽  
Polypropylene Glycol ◽  
Polymer Micelles ◽  
Glycoprotein P ◽  
Block Polymer

Multidrug resistance (MDR) is often caused by the overexpression of efflux pumps, such as ABC transporters, in particular, P-glycoprotein (P-gp). Here, we investigate the di- and tri- block amphiphilic polymer systems based on polypropylene glycol (PPO) and copolymers of (N-(2-hydroxypropyl)methacrylamide) (PHPMA) as potential macromolecular inhibitors of P-gp, and concurrently, carriers of drugs, passively targeting solid tumors by the enhanced permeability and retention (EPR) effect. Interestingly, there were significant differences between the effects of di- and tri- block polymer-based micelles, with the former being significantly more thermodynamically stable and showing much higher P-gp inhibition ability. The presence of Boc-protected hydrazide groups or the Boc-deprotection method did not affect the physico-chemical or biological properties of the block copolymers. Moreover, diblock polymer micelles could be loaded with free PPO containing 5–40 wt % of free PPO, which showed increased P-gp inhibition in comparison to the unloaded micelles. Loaded polymer micelles containing more than 20 wt % free PPO showed a significant increase in toxicity; thus, loaded diblock polymer micelles containing 5–15 wt % free PPO are potential candidates for in vitro and in vivo application as potent MDR inhibitors and drug carriers.

Synthesis and in vitro evaluation of pH-sensitive PEG-I-dC16 block polymer micelles for anticancer drug delivery

2016 ◽  
Vol 68 (6) ◽  
pp. 751-761 ◽  
Author(s):  
Huang Rongbin ◽  
Xiang Lei ◽  
Liu Ying ◽  
Deng Xiangping ◽  
Cao Xuan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Ph Sensitive ◽  
Polymer Micelles ◽  
In Vitro Evaluation ◽  
Block Polymer ◽  
Anticancer Drug Delivery

Multicompartment Block Polymer Micelles

2011 ◽  
Vol 45 (1) ◽  
pp. 2-19 ◽  
Author(s):  
Adam O. Moughton ◽  
Marc A. Hillmyer ◽  
Timothy P. Lodge
Keyword(s):  
Polymer Micelles ◽  
Block Polymer
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