Effect of Molecular Weight and Arm Number on the Growth and pH-Dependent Morphology of Star Poly[2-(dimethylamino)ethyl methacrylate]/Poly(styrenesulfonate) Multilayer Films

2010 ◽  
Vol 43 (21) ◽  
pp. 9087-9093 ◽  
Author(s):  
Zhizhang Guo ◽  
Xingyu Chen ◽  
Jianyu Xin ◽  
Duo Wu ◽  
Jianshu Li ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Multilayer Films ◽  
Ethyl Methacrylate ◽  
Ph Dependent

scholarly journals Contact time- and pH-dependent adhesion and cohesion of low molecular weight chitosan coated surfaces

2015 ◽  
Vol 117 ◽  
pp. 887-894 ◽  
Author(s):  
Chanoong Lim ◽  
Dong Woog Lee ◽  
Jacob N. Israelachvili ◽  
YongSeok Jho ◽  
Dong Soo Hwang
Keyword(s):  
Molecular Weight ◽  
Contact Time ◽  
Low Molecular Weight ◽  
Low Molecular Weight Chitosan ◽  
Ph Dependent ◽  
Coated Surfaces

pH dependent growth of poly(L-lysine)/poly(L-glutamic) acid multilayer films and their cell adhesion properties

2004 ◽  
Vol 570 (1-2) ◽  
pp. 13-29 ◽  
Author(s):  
Ludovic Richert ◽  
Youri Arntz ◽  
Pierre Schaaf ◽  
Jean-Claude Voegel ◽  
Catherine Picart
Keyword(s):  
Cell Adhesion ◽  
Glutamic Acid ◽  
Multilayer Films ◽  
Adhesion Properties ◽  
Ph Dependent ◽  
Dependent Growth

Thermoresponsive properties of 3-, 4-, 6-, and 12-armed star-shaped poly[2-(dimethylamino)ethyl methacrylate]s prepared by core-first group transfer polymerization

2014 ◽  
Vol 5 (16) ◽  
pp. 4701-4709 ◽  
Author(s):  
Seiya Kikuchi ◽  
Yougen Chen ◽  
Keita Fuchise ◽  
Kenji Takada ◽  
Junsuke Kitakado ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Molecular Weight ◽  
Mass Concentration ◽  
Group Transfer ◽  
Ethyl Methacrylate ◽  
Cloud Points

The thermoresponsive behavior of a variety of star-shaped poly[2-(dimethylamino)ethyl methacrylate]s was intensively investigated by evaluating the effect of mass concentration in aqueous solution, molecular weight, or arm number of the polymers on their cloud points.

Molecular Weight Dependence on the Disintegration of Spin-Assisted Weak Polyelectrolyte Multilayer Films

2013 ◽  
Vol 46 (11) ◽  
pp. 4580-4588 ◽  
Author(s):  
Yeongseon Jang ◽  
Jooyeon Seo ◽  
Bulent Akgun ◽  
Sushil Satija ◽  
Kookheon Char
Keyword(s):  
Molecular Weight ◽  
Multilayer Films ◽  
Polyelectrolyte Multilayer ◽  
Molecular Weight Dependence

scholarly journals Intratumoral Distribution and pH-Dependent Drug Release of High Molecular Weight HPMA Copolymer Drug Conjugates Strongly Depend on Specific Tumor Substructure and Microenvironment

2020 ◽  
Vol 21 (17) ◽  
pp. 6029
Author(s):  
Anne-Kathrin Noack ◽  
Henrike Lucas ◽  
Petr Chytil ◽  
Tomáš Etrych ◽  
Karsten Mäder ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Drug Release ◽  
High Molecular Weight ◽  
Cell Lines ◽  
Tumor Tissue ◽  
Tumor Type ◽  
Acidic Microenvironment ◽  
Drug Conjugates ◽  
Ph Dependent ◽  
Intratumoral Distribution

Stimulus-sensitive polymer drug conjugates based on high molecular weight N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers carrying doxorubicin via a pH-dependent cleavable bond (pHPMA-Dox) were previously shown to be able to overcome multi-drug resistance. Nevertheless, a tumor type dependent differential response was observed. Although an improved and more selective tumor accumulation of pHPMA-Dox is generally achieved due to the enhanced permeability and retention (EPR) effect, little is known about the fate of these conjugates upon entering the tumor tissue, which could explain the different responses. In this study, we compared in vitro and in vivo accumulation and Dox-activation of pHPMA-Dox in three cancer cell line models (1411HP, A2780cis, HT29) and derived xenograft tumors using a near-infrared fluorescence-labeled pHPMA-Dox conjugate. Firstly, cytotoxicity assays using different pH conditions proved a stepwise, pH-dependent increase in cytotoxic activity and revealed comparable sensitivity among the cell lines. Using multispectral fluorescence microscopy, we were able to track the distribution of drug and polymeric carrier simultaneously on cellular and histological levels. Microscopic analyses of cell monolayers confirmed the assumed mechanism of cell internalization of the whole conjugate followed by intracellular cleavage and nuclear accumulation of Dox in all three cell lines. In contrast, intratumoral distribution and drug release in xenograft tumors were completely different and were associated with different tissue substructures and microenvironments analyzed by Azan- and Hypoxisense®-staining. In 1411HP tumors, large vessels and less hypoxic/acidic microenvironments were associated with a pattern resulting from consistent tissue distribution and cellular uptake as whole conjugate followed by intracellular drug release. In A2780cis tumors, an inconsistent pattern of distribution partly resulting from premature drug release was associated with a more hypoxic/acidic microenvironment, compacted tumor tissue with compressed vessels and specific pre-damaged tissue structures. A completely different distribution pattern was observed in HT29 tumors, resulting from high accumulation of polymer in abundant fibrotic structures, with small embedded vessels featuring this tumor type together with pronounced premature drug release due to the strongly hypoxic/acidic microenvironment. In conclusion, the pattern of intratumoral distribution and drug release strongly depends on the tumor substructure and microenvironment and may result in different degrees of therapeutic efficacy. This reflects the pronounced heterogeneity observed in the clinical application of nanomedicines and can be exploited for the future design of such conjugates.

pH-Dependent Micellization of Poly(2-vinylpyridine)-block-poly((dimethylamino)ethyl methacrylate) Diblock Copolymers

2001 ◽  
Vol 34 (21) ◽  
pp. 7435-7440 ◽  
Author(s):  
Jean-François Gohy ◽  
Sayed Antoun ◽  
Robert Jérôme
Keyword(s):  
Diblock Copolymers ◽  
Ethyl Methacrylate ◽  
Ph Dependent

Chemical vapour deposition of soluble poly(p-xylylene) copolymers with tuneable properties

2016 ◽  
Vol 7 (1) ◽  
pp. 54-62 ◽  
Author(s):  
Ilka E. Paulus ◽  
Markus Heiny ◽  
V. Prasad Shastri ◽  
Andreas Greiner
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Chemical Vapour Deposition ◽  
Vapour Deposition ◽  
Chemical Vapour ◽  
Ethyl Methacrylate ◽  
High Molecular Weight Poly ◽  
Soluble Poly

High-molecular weight poly(p-xylylene) (PPX)/2-hydroxy-ethyl methacrylate (HEMA) copolymers are synthesized by chemical vapour deposition. The copolymer coatings are hydrophilic and show good cytocompatibility.

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