Synthesis of Temperature Responsive Biohybrid Guar-Based Grafted Copolymers by Click Chemistry

2010 ◽  
Vol 43 (16) ◽  
pp. 6843-6852 ◽  
Author(s):  
Morgan Tizzotti ◽  
Caroline Creuzet ◽  
Marie-Pierre Labeau ◽  
Thierry Hamaide ◽  
Fernande Boisson ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Temperature Responsive

scholarly journals Nanohybrid polymer brushes on silica for bioseparation

2016 ◽  
Vol 4 (19) ◽  
pp. 3247-3256 ◽  
Author(s):  
Lingdong Jiang ◽  
Héctor Bagán ◽  
Tripta Kamra ◽  
Tongchang Zhou ◽  
Lei Ye
Keyword(s):  
Atom Transfer Radical Polymerization ◽  
Click Chemistry ◽  
Radical Polymerization ◽  
Polymer Brushes ◽  
Atom Transfer ◽  
Temperature Responsive ◽  
Responsive Polymer

Surface-initiated atom transfer radical polymerization and click chemistry are used to synthesize temperature-responsive polymer brushes for glycoprotein separation.

Retrieval of resorptive human osteoclasts from temperature-responsive plastic

2016 ◽  
Author(s):  
Arjen Gebraad ◽  
Teuvo Hentunen ◽  
Tiina Laitala-Leinonen
Keyword(s):  
Temperature Responsive ◽  
Human Osteoclasts

Click Chemistry Expedited Radiosynthesis: Sulfur [18F]fluoride Exchange of Aryl Fluorosulfates

2019 ◽  
Author(s):  
Qinheng Zheng ◽  
Hongtao Xu ◽  
Hua Wang ◽  
Wen-Ge Han Du ◽  
Nan Wang ◽  
...  
Keyword(s):  
Click Chemistry ◽  
High Performance ◽  
Isotopic Exchange ◽  
Tumor Imaging ◽  
Radiochemical Yield ◽  
Exchange Method ◽  
Molar Activity ◽  
Positron Emission ◽  
Sulfur Fluoride

The lack of simple, efficient [<sup>18</sup>F]fluorination processes and new target-specific organofluorine probes remains the major challenge of fluorine-18-based positron emission tomography (PET). We report here a fast isotopic exchange method for the radiosynthesis of aryl [<sup>18</sup>F]fluorosulfate based PET agents enabled by the emerging sulfur fluoride exchange (SuFEx) click chemistry. The method has been applied to the fully-automated <sup>18</sup>F-radiolabeling of twenty-five structurally diverse aryl fluorosulfates with excellent radiochemical yield (83–100%) and high molar activity (up to 281 GBq µmol<sup>–1</sup>) at room temperature in 30 seconds. The purification of radiotracers requires no time-consuming high-performance liquid chromatography (HPLC), but rather a simple cartridge filtration. The utility of aryl [<sup>18</sup>F]fluorosulfate is demonstrated by the <i>in vivo</i> tumor imaging by targeting poly(ADP-ribose) polymerase 1 (PARP1).

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