Cationic Polyacrylamide Conformation on Mica Studied by Single Molecule “Pulling” with Scanning Probe Microscopy

2007 ◽  
Vol 40 (13) ◽  
pp. 4561-4567 ◽  
Author(s):  
Brett Brotherson ◽  
Lawrence A. Bottomley ◽  
Peter Ludovice ◽  
Yulin Deng
Keyword(s):  
Single Molecule ◽  
Scanning Probe Microscopy ◽  
Scanning Probe ◽  
Probe Microscopy ◽  
Cationic Polyacrylamide

Developments in Using Scanning Probe Microscopy To Study Molecules on Surfaces — From Thin Films and Single-Molecule Conductivity to Drug–Living Cell Interactions

2006 ◽  
Vol 59 (6) ◽  
pp. 359 ◽  
Author(s):  
Pall Thordarson ◽  
Rob Atkin ◽  
Wouter H. J. Kalle ◽  
Gregory G. Warr ◽  
Filip Braet
Keyword(s):  
Single Molecule ◽  
Scanning Probe Microscopy ◽  
Cell Interactions ◽  
Scanning Probe ◽  
Probe Microscopy ◽  
Force Microscopy ◽  
Atomic Force ◽  
Tunnelling Microscopy ◽  
Molecule Surface

Scanning probe microscopy (SPM) techniques, including atomic force microscopy (AFM) and scanning tunnelling microscopy (STM), have revolutionized our understanding of molecule–surface interactions. The high resolution and versatility of SPM techniques have helped elucidate the morphology of adsorbed surfactant layers, facilitated the study of electronically conductive single molecules and biomolecules connected to metal substrates, and allowed direct observation of real-time processes such as in situ DNA hybridization and drug–cell interactions. These examples illustrate the power that SPM possesses to study (bio)molecules on surfaces and will be discussed in depth in this review.

scholarly journals Spatially Correlated Single Molecule Spectroscopy and Scanning Probe Microscopy for Characterizing Aggregation of Semiconductor Nanocrystals and Biomolecules

2009 ◽  
Vol 15 (S2) ◽  
pp. 838-839
Author(s):  
A Van Orden ◽  
D Shepherd ◽  
M Yu
Keyword(s):  
Single Molecule ◽  
Scanning Probe Microscopy ◽  
Semiconductor Nanocrystals ◽  
Scanning Probe ◽  
Single Molecule Spectroscopy ◽  
Probe Microscopy ◽  
Spatially Correlated

Extended abstract of a paper presented at Microscopy and Microanalysis 2009 in Richmond, Virginia, USA, July 26 – July 30, 2009

scholarly journals Virtual reality visual feedback for hand-controlled scanning probe microscopy manipulation of single molecules

2015 ◽  
Vol 6 ◽  
pp. 2148-2153 ◽  
Author(s):  
Philipp Leinen ◽  
Matthew F B Green ◽  
Taner Esat ◽  
Christian Wagner ◽  
F Stefan Tautz ◽  
...  
Keyword(s):  
Virtual Reality ◽  
Visual Feedback ◽  
Single Molecule ◽  
Scanning Probe Microscopy ◽  
Single Molecules ◽  
Scanning Probe ◽  
Probe Microscopy ◽  
Atomic Force ◽  
Set Up ◽  
Molecular Compounds

Controlled manipulation of single molecules is an important step towards the fabrication of single molecule devices and nanoscale molecular machines. Currently, scanning probe microscopy (SPM) is the only technique that facilitates direct imaging and manipulations of nanometer-sized molecular compounds on surfaces. The technique of hand-controlled manipulation (HCM) introduced recently in Beilstein J. Nanotechnol. 2014, 5, 1926–1932 simplifies the identification of successful manipulation protocols in situations when the interaction pattern of the manipulated molecule with its environment is not fully known. Here we present a further technical development that substantially improves the effectiveness of HCM. By adding Oculus Rift virtual reality goggles to our HCM set-up we provide the experimentalist with 3D visual feedback that displays the currently executed trajectory and the position of the SPM tip during manipulation in real time, while simultaneously plotting the experimentally measured frequency shift (Δf) of the non-contact atomic force microscope (NC-AFM) tuning fork sensor as well as the magnitude of the electric current (I) flowing between the tip and the surface. The advantages of the set-up are demonstrated by applying it to the model problem of the extraction of an individual PTCDA molecule from its hydrogen-bonded monolayer grown on Ag(111) surface.

The Role of Scanning Probe Microscopy in Drug Delivery Research

1996 ◽  
Vol 13 (3-4) ◽  
pp. 225-256 ◽  
Author(s):  
Kevin M. Shakesheff ◽  
Martyn C. Davies ◽  
Clive J. Roberts ◽  
Saul J. B. Tendler ◽  
Philip M. Williams
Keyword(s):  
Drug Delivery ◽  
Scanning Probe Microscopy ◽  
Scanning Probe ◽  
Probe Microscopy
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