Interaction of Poly(methacrylic acid) Brushes with Metal Ions:  Swelling Properties

2005 ◽  
Vol 38 (10) ◽  
pp. 4345-4354 ◽  
Author(s):  
Rupert Konradi ◽  
Jürgen Rühe
Keyword(s):  
Metal Ions ◽  
Methacrylic Acid ◽  
Swelling Properties

Adsorption of Dyes and Metal Ions by Acrylamide - Co - Acrylic Acid Hydrogels Synthesized by Gamma Radiation

2009 ◽  
Vol 609 ◽  
pp. 255-259 ◽  
Author(s):  
L. Aberkane-Mechebbek ◽  
S.F. Larbi-Youcef ◽  
M. Mahlous
Keyword(s):  
Acrylic Acid ◽  
Gamma Radiation ◽  
Metal Ions ◽  
Congo Red ◽  
Methyl Violet ◽  
Absorbed Dose ◽  
Swelling Properties ◽  
Swelling Rate ◽  
Ionic Nature ◽  
Dye Diffusion

Hydrogel based on acrylamide and acrylic acid was synthesized and crosslinked by gamma radiation at an absorbed dose of 8 kGy. Swelling properties of the hydrogel in water and in methyl violet and Congo red solutions were investigated. The results showed that the swelling rate of the hydrogel depends on the pH and the ionic nature of the dye. Diffusion of water and dyes solutions within the hydrogel was found to be of non-Fickian character. Contrary to the swelling behavior, the capacity of the hydrogel to adsorb dyes seems to be higher at weak pHs. Concerning metal ions uptake, the results showed that adsorption of Cu2+ increases with pH increasing from pH1 to pH4.

Fabrication and characterization of a novel semi-interpenetrating network hydrogel based on sodium carboxymethyl cellulose and poly(methacrylic acid) for oral insulin delivery

2020 ◽  
Vol 35 (1) ◽  
pp. 3-14
Author(s):  
Shunying Li ◽  
Zhiru Chen ◽  
Jun Wang ◽  
Libiao Yan ◽  
Tingting Chen ◽  
...  
Keyword(s):  
Oral Administration ◽  
Methacrylic Acid ◽  
Carboxymethyl Cellulose ◽  
Polymer Network ◽  
Insulin Delivery ◽  
Interpenetrating Polymer Network ◽  
Sodium Carboxymethyl Cellulose ◽  
Oral Insulin ◽  
Swelling Properties

In this research, pH-sensitive semi-interpenetrating polymer network hydrogels based on sodium carboxymethyl cellulose and poly(methacrylic acid) were synthesized using free radical polymerization and semi-interpenetrating polymer network approach for oral administration of insulin. The chemical structure and thermal stability of the hydrogels were characterized using Fourier transform infrared spectroscopy, X-ray diffraction, and thermogravimetric analysis measurements. The interior morphology was observed by scanning electron microscopy and the inner structure exhibited a porous honeycomb-like shape. The investigations on the swelling properties of hydrogels revealed their ability to response to pH value change. The in vitro release behavior of insulin was pH dependent and the release of insulin was much lower at pH 1.2 compared to pH 6.8. In vitro cytotoxicity assay indicated that the hydrogels were noncytotoxic to HeLa cells. A sustained reduction in blood glucose level was observed after oral administration of insulin-loaded hydrogel to diabetic rats at 75 IU/kg. These results indicated that the hydrogel would be a promising vehicle for oral insulin delivery systems.

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