Temperature-Controlled Behavior of Self-Assembly Gene Delivery Vectors Based on Complexes of DNA with Poly(l-lysine)-graft-poly(N-isopropylacrylamide)

2003 ◽  
Vol 36 (18) ◽  
pp. 6863-6872 ◽  
Author(s):  
David Oupický ◽  
Tomáš Reschel ◽  
Čestmír Koňák ◽  
Libuše Oupická
Keyword(s):  
Gene Delivery ◽  
Self Assembly ◽  
Gene Delivery Vectors ◽  
Temperature Controlled

Supramolecular Polymers for Potential Biomedical Applications

2011 ◽  
Vol 410 ◽  
pp. 94-97 ◽  
Author(s):  
Jun Li
Keyword(s):  
Tissue Engineering ◽  
Block Copolymers ◽  
Gene Delivery ◽  
Self Assembly ◽  
Functional Materials ◽  
Supramolecular Structures ◽  
Potential Drug ◽  
Engineering Applications ◽  
Supramolecular Architectures ◽  
Gene Delivery Vectors

The phenomena of molecular self-assembly have inspired interesting development of novel functional materials. We have been focusing on developing novel polymers with the ability to self-assemble into novel supramolecular structures, which can function as biomaterials for potential drug/gene delivery and tissue engineering applications. The key components in our macromolecular self-assembling structures include the biodegradable and biocompatible microbial biopolyesters, poly (β-hydroxyalkanoates), and the macrocyclic polysaccharides, cyclodextrins. A series of novel block copolymers and interlocked supramolecular architectures were designed and synthesized. They were characterized in terms of their molecular and supramolecular structures, as well as their properties and functions as biomaterials for potential drug and gene delivery, and tissue engineering applications. Amphiphilic block copolymers of different chain architectures composed of poly [(R)-3-hydroxybutyrate] as hydrophobic segments, and poly (ethylene glycol), poly (propylene glycol), or poly (N-isopropylacrylamide) as hydrophilic segments were synthesized. They could self-assemble to form stable micelles, nanopatterning thin films, and thermo-sensitive hydrogels, which were demonstrated to be promising potential biomaterials for controlled and sustained delivery of drugs and tissue engineering scaffolding materials. The self-assembly of block copolymers with cyclodextrins resulted in supramolecular hydrogels and cationic supramolecules, which were used as injectable drug delivery systems, and novel polymeric gene delivery vectors.

Recent advances in the analysis full/empty capsid ratio and genome integrity of adeno-associated virus (AAV) gene delivery vectors

2020 ◽  
Vol 20 ◽  
Author(s):  
L. Hajba ◽  
A. Guttman
Keyword(s):  
Gene Delivery ◽  
High Efficiency ◽  
Analytical Techniques ◽  
Viral Gene ◽  
Adeno Associated Virus ◽  
Gene Delivery Vectors ◽  
Empty Capsid ◽  
Purification Methods ◽  
Viral Gene Delivery

: Adeno-associated virus (AAV) is one of the most promising viral gene delivery vectors with long-term gene expression and disease correction featuring high efficiency and excellent safety in human clinical trials. During the production of AAV vectors,there are several quality control (QC)parameters that should be rigorously monitored to comply with clini-cal safety and efficacy. This review gives a short summary of the most frequently used AVV production and purification methods,focusing on the analytical techniques applied to determine the full/empty capsid ratio and the integrity of the encapsidated therapeutic DNA of the products.

Hierarchical Self-Assembly Route to “Polyplex-in-Hydrophobic-Core” Micelles for Gene Delivery

2021 ◽  
Vol 33 (17) ◽  
pp. 6860-6875
Author(s):  
Sundiata Kly ◽  
Lucas J. Andrew ◽  
Erin G. Moloney ◽  
Yuhang Huang ◽  
Jeremy E. Wulff ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Self Assembly ◽  
Hydrophobic Core

pH-sensitive N,N-(dimethyl)-N-alkanamine-N-oxides as gene delivery vectors

2017 ◽  
Vol 71 (9) ◽  
pp. 1739-1748 ◽  
Author(s):  
Gilda Liskayová ◽  
Lukáš Hubčík ◽  
Katarína Šišková ◽  
Ingrid Pauliková ◽  
Dominika Galliková ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Ph Sensitive ◽  
Gene Delivery Vectors

scholarly journals Magnetic Nanoparticle Assisted Self-assembly of Cell Penetrating Peptides-Oligonucleotides Complexes for Gene Delivery

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Moataz Dowaidar ◽  
Hani Nasser Abdelhamid ◽  
Mattias Hällbrink ◽  
Krista Freimann ◽  
Kaido Kurrikoff ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Self Assembly ◽  
Magnetic Nanoparticle ◽  
Cell Penetrating Peptides ◽  
Cell Penetrating

Structure–activity relationship studies of symmetrical cationic bolasomes as non-viral gene vectors

2016 ◽  
Vol 4 (33) ◽  
pp. 5575-5584 ◽  
Author(s):  
Zheng Huang ◽  
Yi-Mei Zhang ◽  
Qian Cheng ◽  
Ji Zhang ◽  
Yan-Hong Liu ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Viral Gene ◽  
Structure Activity ◽  
Gene Delivery Vectors ◽  
Gene Vectors

Bolalipids based on lysine or cyclen headgroups were synthesized and their structure–activity relationship as gene delivery vectors was studied.

Innate immune response induced by gene delivery vectors

2008 ◽  
Vol 354 (1-2) ◽  
pp. 9-15 ◽  
Author(s):  
Haruna Sakurai ◽  
Kenji Kawabata ◽  
Fuminori Sakurai ◽  
Shinsaku Nakagawa ◽  
Hiroyuki Mizuguchi
Keyword(s):  
Immune Response ◽  
Gene Delivery ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Gene Delivery Vectors

scholarly journals Design of Hybrid Lipid/Retroviral-Like Particle Gene Delivery Vectors

2013 ◽  
Vol 10 (5) ◽  
pp. 1725-1735 ◽  
Author(s):  
Rahul K. Keswani ◽  
Ian M. Pozdol ◽  
Daniel W. Pack
Keyword(s):  
Gene Delivery ◽  
Gene Delivery Vectors

scholarly journals Cationic lipids with a cyclen headgroup: synthesis and structure–activity relationship studies as non-viral gene vectors

RSC Advances ◽  
2017 ◽  
Vol 7 (30) ◽  
pp. 18681-18689 ◽  
Author(s):  
De-Chun Chang ◽  
Yi-Mei Zhang ◽  
Ji Zhang ◽  
Yan-Hong Liu ◽  
Xiao-Qi Yu
Keyword(s):  
Gene Delivery ◽  
Structure Activity Relationship ◽  
Cationic Lipids ◽  
Activity Relationship ◽  
Viral Gene ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Gene Delivery Vectors ◽  
Gene Vectors ◽  
Viral Gene Delivery

The structure–activity relationships of cyclen-based cationic lipids as non-viral gene delivery vectors were studied and clarified.

Cholesterol derived cationic lipids as potential non-viral gene delivery vectors and their serum compatibility

2016 ◽  
Vol 26 (10) ◽  
pp. 2401-2407 ◽  
Author(s):  
Jia Ju ◽  
Meng-Lei Huan ◽  
Ning Wan ◽  
Yi-Lin Hou ◽  
Xi-Xi Ma ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Cationic Lipids ◽  
Viral Gene ◽  
Gene Delivery Vectors ◽  
Viral Gene Delivery
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