Cholesteryl-(l-Lactic Acid)n̄Building Blocks for Self-Assembling Biomaterials

2002 ◽  
Vol 35 (3) ◽  
pp. 746-759 ◽  
Author(s):  
Harm-Anton Klok ◽  
Julia J. Hwang ◽  
Subramani N. Iyer ◽  
Samuel I. Stupp
Keyword(s):  
Lactic Acid ◽  
Self Assembling

The effect of the length of terminal n-alkyl carboxylate chain on self-assembling and photosensitive properties of chiral lactic acid derivatives

2019 ◽  
Vol 275 ◽  
pp. 829-838 ◽  
Author(s):  
Anna Poryvai ◽  
Alexej Bubnov ◽  
Damian Pociecha ◽  
Jiří Svoboda ◽  
Michal Kohout
Keyword(s):  
Lactic Acid ◽  
Self Assembling

scholarly journals Mechanical and Thermal Characteristics of Bio-Nanocomposites Consisting of Poly-L-lactic Acid and Self-Assembling Siloxane Nanoparticles with Three Phases

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Masatoshi Iji ◽  
Naoki Morishita
Keyword(s):  
Lactic Acid ◽  
Thermal Characteristics ◽  
Decomposition Temperature ◽  
Maximum Strength ◽  
Breaking Strain ◽  
Self Assembling ◽  
Heat Distortion Temperature ◽  
Average Size ◽  
The Impact ◽  
Three Phases

Biopolymer nanocomposites (bio-nanocomposite) consisting of poly-L-lactic acid (PLLA) and siloxane nanoparticles with three phases, a high-density siloxane phase (plural cores), an elastomeric silicone phase, and a caprolactone oligomer phase, were developed to increase the mechanical properties of PLLA. The nanoparticles, average size of 13 nm, were self-assembled by aggregation and condensation of an organosiloxane with three units: isocyanatepropyltrimethoxysilane (IPTS), polymethylpropyloxysiloxane (PMPS), and a caprolactone oligomer (CLO), which form each phase. The bio-nanocomposite was produced using PLLA and the nanoparticles. Bending and tensile testing showed that the use of these nanoparticles (5 wt% in PLLA) greatly increases the tenacity (breaking strain) of PLLA while maintaining its relatively high breaking (maximum) strength. The elongation of the nanocomposite was more than twice that of PLLA while the elasticity modulus and breaking (maximum) strength were comparable to those of PLLA. The nanoparticles also increased the impact strength of PLLA. The use of the nanoparticles almost did not show adverse affect on the thermal resistance of PLLA. The nanocomposite’s heat resistance indicated by the glass transition temperature and heat distortion temperature was fairly kept. The decomposition temperature of the nanocomposite somewhat increased.

scholarly journals A novel sensor for sequential and cellular detection of copper and lactic acid

2020 ◽  
Author(s):  
Nidhi Gour ◽  
Sumit Kharbanda ◽  
Deepak Kumar Pandey ◽  
Dheeraj K Singh ◽  
Dhiraj Bhatia ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Density Functional ◽  
Limit Of Detection ◽  
Sequential Detection ◽  
Yellow Fluorescence ◽  
Self Assembling ◽  
Golden Yellow ◽  
Wide Range ◽  
Dual Sensor ◽  
Lactate Levels

<div> <p>We report self assembling/aggregation properties of acyl-thiourea derivative, N-((6-methoxy-pyridin-2-yl)carbamothioyl)benzamide<a>(<b>NG1</b>) </a><a>[i1]</a> and the disaggregation induced emission which leads to its application as fluorescence and colorimetric probe for the sensitive detection of Cu<sup>2+</sup>. The microscopy analysis of <b>NG1</b>via SEM, and AFM reveal that it self-assembles to give fiber-like morphologies.Interestingly,<b>NG1</b> also assembles to fluorescent fibers which show tunable emission properties. Addition of Cu<sup>2+</sup>to these fibers causedisruption/disaggregation of fibers and a golden yellow fluorescence is produced due to disaggregation induced emission enhancement (DIEE). The application of <b>NG1</b> as selective sensor for copper was further assessed by UV visible and fluorescence spectroscopy. Limit of Detection(LOD) of Cu<sup>2+ </sup>with colorimetry was 2.5ppm while LOD of Cu<sup>2+</sup> with fluorescence was as low as 0.1ppm. This yellow fluorescence is quenched after the addition of lactic acid and hence <b>NG1</b> could potentially be used for the sequential detection of both Cu and lactate.Further, structural modification of the probe <b>NG1</b> suggest crucial role of both pyridine and acyl-thiourea moiety in the binding of Cu<sup>2+</sup>. The experimental results of interaction of <b>NG1</b> with Cu<sup>2+</sup> and lactate were also validated theoretically by quantum chemical calculations based on density functional theory (DFT). Finally, we explore the ability of <b>NG1</b>for the sequential detection of Cu<sup>2+</sup> and lactate in cells, which suggests<b>NG1</b> can be used effectively for the cellular imaging applications and to selectively sense Cu<sup>2+</sup>. To, the best of our knowledge,</p></div> <p>this is the first report wherein a dual sensor for Cu<sup>2+</sup>and lactate ion is synthesized and it may in allpossibilities pave the way for the diagnosis of Cu<sup>2+</sup>associated disorders like Wilson’s disease and in the detection of elevated lactate levels which are associated with the wide range of pathologies likemitochondrial diseases, cerebral ischemia and cancer.<b></b></p> <div> </div><br>

Modification of fibrous poly(l-lactic acid) scaffolds with self-assembling triblock molecules

Biomaterials ◽  
2004 ◽  
Vol 25 (27) ◽  
pp. 5847-5856 ◽  
Author(s):  
John C Stendahl ◽  
Leiming Li ◽  
Randal C Claussen ◽  
Samuel I Stupp
Keyword(s):  
Lactic Acid ◽  
Self Assembling

scholarly journals Self-assembling biomaterials: Liquid crystal phases of cholesteryl oligo(L-lactic acid) and their interactions with cells

2002 ◽  
Vol 99 (15) ◽  
pp. 9662-9667 ◽  
Author(s):  
J. J. Hwang ◽  
S. N. Iyer ◽  
L.-S. Li ◽  
R. Claussen ◽  
D. A. Harrington ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Liquid Crystal ◽  
Self Assembling ◽  
Crystal Phases ◽  
Liquid Crystal Phases

scholarly journals Design of polar self-assembling lactic acid derivatives possessing submicrometre helical pitch

2018 ◽  
Vol 9 ◽  
pp. 333-341 ◽  
Author(s):  
Alexej Bubnov ◽  
Cyril Vacek ◽  
Michał Czerwiński ◽  
Terezia Vojtylová ◽  
Wiktor Piecek ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Liquid Crystalline ◽  
Room Temperature ◽  
Scanning Calorimetry ◽  
Alkyl Chains ◽  
Temperature Range ◽  
Helical Pitch ◽  
Self Assembling ◽  
Electro Optic ◽  
Nanoscale Level

Several new lactic acid derivatives containing the keto linkage group far from the chiral part and short alkyl chains have been synthesized and characterised by polarising optical microscopy, differential scanning calorimetry, as well as electro-optic and dielectric spectroscopy. The materials possess a self-assembling behaviour on the nanoscale level as they form polar smectic liquid crystalline mesophases, namely the orthogonal paraelectric SmA* and the tilted ferroelectric SmC* phases, in a broad temperature range down to room temperature. A short helical pitch (≈120–320 nm), relatively high spontaneous polarisation (≈150 nC/cm2) and reasonable tilt angle values have been determined within the temperature range of the tilted ferroelectric SmC* phase. The obtained results make the new materials useful for the advanced mixture design and for further utilisation in electro-optic devices based on the deformed helix ferroelectric effect.

Effect of a bulky lateral substitution by chlorine atom and methoxy group on self-assembling properties of lactic acid derivatives

2014 ◽  
Vol 146 (1-2) ◽  
pp. 18-25 ◽  
Author(s):  
Maja Stojanović ◽  
Alexej Bubnov ◽  
Dušanka Ž. Obadović ◽  
Věra Hamplová ◽  
Miroslav Cvetinov ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Chlorine Atom ◽  
Methoxy Group ◽  
Self Assembling
Sign in / Sign up

Export Citation Format

Share Document