Radical reactions of highly polar molecules. Hydrocarbons as chain-transfer agents in fluoro olefin telomerizations

1983 ◽  
Vol 16 (3) ◽  
pp. 357-359 ◽  
Author(s):  
Leonard O. Moore
Keyword(s):  
Chain Transfer ◽  
Radical Reactions ◽  
Polar Molecules ◽  
Transfer Agents

Pseudoliving polymerization of vinyl acetate mediated by reversible addition-fragmentation chain-transfer agents

2011 ◽  
Vol 53 (7-8) ◽  
pp. 437-447 ◽  
Author(s):  
E. V. Chernikova ◽  
V. V. Yulusov ◽  
K. O. Mineeva ◽  
V. B. Golubev ◽  
E. S. Garina
Keyword(s):  
Vinyl Acetate ◽  
Chain Transfer ◽  
Reversible Addition ◽  
Transfer Agents

Living Radical Polymerization with Reversible Addition−Fragmentation Chain Transfer (RAFT Polymerization) Using Dithiocarbamates as Chain Transfer Agents

1999 ◽  
Vol 32 (21) ◽  
pp. 6977-6980 ◽  
Author(s):  
Roshan T. A. Mayadunne ◽  
Ezio Rizzardo ◽  
John Chiefari ◽  
Yen Kwong Chong ◽  
Graeme Moad ◽  
...  
Keyword(s):  
Radical Polymerization ◽  
Chain Transfer ◽  
Raft Polymerization ◽  
Living Radical Polymerization ◽  
Reversible Addition ◽  
Transfer Agents

Vinyl Sulfonate Esters: Efficient Chain Transfer Agents for the 3D Printing of Tough Photopolymers without Retardation

2018 ◽  
Vol 57 (29) ◽  
pp. 9165-9169 ◽  
Author(s):  
Konstanze Seidler ◽  
Markus Griesser ◽  
Markus Kury ◽  
Reghunathan Harikrishna ◽  
Peter Dorfinger ◽  
...  
Keyword(s):  
3D Printing ◽  
Chain Transfer ◽  
Transfer Agents

One-Pot Heterotelechelic Metathesis Polymers via Regioselective Chain Transfer Agents

2021 ◽  
pp. 1487-1492
Author(s):  
Ankita Mandal ◽  
Indradip Mandal ◽  
Andreas F. M. Kilbinger
Keyword(s):  
Chain Transfer ◽  
One Pot ◽  
Transfer Agents

One-Pot Synthesis of Ion-Containing CO2-Based Polycarbonates Using Protic Ionic Liquids as Chain Transfer Agents

2018 ◽  
Vol 51 (22) ◽  
pp. 9122-9130 ◽  
Author(s):  
Zhaohe Huang ◽  
Yanyan Wang ◽  
Na Zhang ◽  
Luhong Zhang ◽  
Donald J. Darensbourg
Keyword(s):  
Ionic Liquids ◽  
Chain Transfer ◽  
Protic Ionic Liquids ◽  
One Pot ◽  
One Pot Synthesis ◽  
Transfer Agents

Allyl sulfides and α-substituted acrylates as addition-fragmentation chain transfer agents for methacrylate polymer networks

2015 ◽  
Vol 54 (3) ◽  
pp. 394-406 ◽  
Author(s):  
Samuel Clark Ligon ◽  
Konstanze Seidler ◽  
Christian Gorsche ◽  
Markus Griesser ◽  
Norbert Moszner ◽  
...  
Keyword(s):  
Chain Transfer ◽  
Polymer Networks ◽  
Allyl Sulfides ◽  
Transfer Agents

scholarly journals Cell Culture Characterization of Prooxidative Chain-Transfer Agents as Novel Cytostatic Drugs

Molecules ◽  
2021 ◽  
Vol 26 (21) ◽  
pp. 6743
Author(s):  
Victoria Heymans ◽  
Sascha Kunath ◽  
Parvana Hajieva ◽  
Bernd Moosmann
Keyword(s):  
Chain Transfer ◽  
Human Tumor ◽  
C2c12 Cells ◽  
Hek293 Cells ◽  
Maximum Effect ◽  
Cytostatic Drugs ◽  
Clinical Role ◽  
Human Neuroblastoma ◽  
Transfer Agents

Prooxidative therapy is a well-established concept in infectiology and parasitology, in which prooxidative drugs like artemisinin and metronidazole play a pivotal clinical role. Theoretical considerations and earlier studies have indicated that prooxidative therapy might also represent a promising strategy in oncology. Here, we have investigated a novel class of prooxidative drugs, namely chain-transfer agents, as cytostatic agents in a series of human tumor cell lines in vitro. We have found that different chain-transfer agents of the lipophilic thiol class (like dodecane-1-thiol) elicited half-maximal effective concentrations in the low micromolar range in SY5Y cells (human neuroblastoma), Hela cells (human cervical carcinoma), HEK293 cells (immortalized human kidney), MCF7 cells (human breast carcinoma), and C2C12 cells (mouse myoblast). In contrast, HepG2 cells (human hepatocellular carcinoma) were resistant to toxicity, presumably through their high detoxification capacity for thiol groups. Cytotoxicity was undiminished by hypoxic culture conditions, but substantially lowered after cellular differentiation. Compared to four disparate, clinically used reference compounds in vitro (doxorubicin, actinomycin D, 5-fluorouracil, and hydroxyurea), chain-transfer agents emerged as comparably potent on a molar basis and on a maximum-effect basis. Our results indicate that chain-transfer agents possess a promising baseline profile as cytostatic drugs and should be explored further for anti-tumor chemotherapy.

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