The First Report of Cyclopolymerization of Bis(oxazolines) To Give Optically Active Polymacrocycles

1995 ◽  
Vol 28 (1) ◽  
pp. 390-392 ◽  
Author(s):  
Rutger D. Puts ◽  
Dotsevi Y. Sogah
Keyword(s):  
Optically Active ◽  
First Report

Urinary sediments in sheep feeding on oestrogenic clover. III.* The identification of 4′-O-methyl equol as a major component of some sediments

1974 ◽  
Vol 25 (3) ◽  
pp. 509 ◽  
Author(s):  
MC Nottle ◽  
AB Beck
Keyword(s):  
Calcium Salt ◽  
Optically Active ◽  
The Other ◽  
Biochanin A ◽  
Chemical Identification ◽  
Main Metabolite ◽  
First Report

Chemical identification has been made of two types of sediment formed in the urine of sheep ingesting clovers high in formononetin. One type, described previously, consists of the calcium salt of the glucuronide of 4′-O-methyl equol (4′-methoxy-7-isoflavanol). The other contains unconjugated 4′-O-methyl equol associated with small amounts of equol, formononetin and biochanin A. This is the first report of the isolation of optically active 4′-O-methyl equol. The present findings indicate that, under some conditions, at present undefined, 4′-O-methyl equol may replace equol as the main metabolite of formononetin. When administered subcutaneously into mice, 4′-O-methyl equol is slightly less oestrogenic than equol, and its possible role in 'clover disease' of sheep is discussed. ____________________ *Part II, Aust. J. Agric. Res., 23: 693 (1972).

Short and Diastereoselective Total Synthesis of the Polyhydroxylated Pyrrolidine LAB-1: A Potent α-Glycosidase Inhibitor

Synthesis ◽  
2017 ◽  
Vol 49 (21) ◽  
pp. 4869-4875 ◽  
Author(s):  
Fernando Coelho ◽  
Erica da Silva ◽  
Nathália Yamakawa ◽  
Alcindo Dos Santos
Keyword(s):  
Total Synthesis ◽  
Optically Active ◽  
Biologically Active ◽  
First Report ◽  
Glycosidase Inhibitor

We described herein a total synthesis of 1,4-dideoxy-1,4-imino-l-arabinitol [(2S,3S,4S)-2-(hydroxymethyl)pyrrolidine-3,4-diol, LAB-1], a polyhydroxylated pyrrolidine, which has been demonstrated to be a selective and potent α-glycosidase inhibitor. The main features of our approach are its shortness, efficiency, and simplicity. The total synthesis was accomplished in 6 steps with an overall yield of 12%, starting from a chiral optically active Morita–Baylis–Hillman (MBH) adduct prepared (without epimerization), from Garner’s aldehyde. As far as we know, this is the first report describing the total synthesis of this biologically active pyrrolidine by exploring the synthetic versatility of a MBH adduct.

A fossil Aspergillus from Eocene Dominican amber

1988 ◽  
Vol 62 (01) ◽  
pp. 141-143 ◽  
Author(s):  
Gerard M. Thomas ◽  
George O. Poinar
Keyword(s):  
Dominican Republic ◽  
Fossil Species ◽  
First Report ◽  
Dominican Amber ◽  
Eocene Amber

A sporulating Aspergillus is described from a piece of Eocene amber originating from the Dominican Republic. The Aspergillus most closely resembles a form of the white spored phase of Aspergillus janus Raper and Thom. This is the first report of a fossil species of Aspergillus.

1392: First Report of a New Transurethral Detaching Prostatectomy of the Prostate (TUDP)

2005 ◽  
Vol 173 (4S) ◽  
pp. 377-378
Author(s):  
Yasunori Hiraoka ◽  
Kazuhiko Yamada ◽  
Yuji Shimizu ◽  
Hiroyuki Abe
Keyword(s):  
First Report
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