scholarly journals Cross-Linking Induced Phase Separation in SAN/SMA Semi-interpenetrating Polymer Networks Observed by Solid State NMR and Site Specific Isotope Enrichment

2000 ◽  
Vol 33 (15) ◽  
pp. 5544-5548 ◽  
Author(s):  
F. M. Mulder ◽  
W. Heinen ◽  
M. van Duin ◽  
J. Lugtenburg ◽  
H. J. M. de Groot
Keyword(s):  
Phase Separation ◽  
Solid State ◽  
Solid State Nmr ◽  
Polymer Networks ◽  
Interpenetrating Polymer Networks ◽  
Cross Linking ◽  
Isotope Enrichment ◽  
Site Specific

Development and Characterization of LBG-PVA Interpenetrating Networks Incorporating Gliclazide for Sustained Release

2020 ◽  
Vol 15 ◽  
Author(s):  
Ashish Katoch ◽  
Manju Nagpal ◽  
Malkiet Kaur ◽  
Manjinder Singh ◽  
Geeta Aggarwal ◽  
...  
Keyword(s):  
Solid State ◽  
Sustained Release ◽  
Half Life ◽  
Solid State Nmr ◽  
Oral Dosage ◽  
Cross Linking ◽  
Interpenetrating Networks ◽  
Dsc Studies ◽  
Biological Half Life ◽  
Percentage Yield

Background: Controlled oral dosage forms have always been preferred for drugs with variable absorption, and short biological half life and frequent dosing. The prime goal with sustained release systems is to maintain uniform therapeutic blood levels for longer periods of time. Interpenetrating networks (IPNs) have been evidenced as uniform sustained release systems. In current study, polyvinyl alcohol (PVA) and locust bean gum (LBG) based IPNs were developed for the oral sustained release drug delivery of gliclazide (shows variable absorption). Method: The IPNs were synthesized by emulsion cross-linking method using glutaraldehyde (GA) as a cross linking agent. Gliclazide is a potential second generation, short-acting sulfonylurea oral hypoglycemic agent is having a short biological half-life (2-4 h), variable absorption and poor oral bioavailability. Various batches of IPNs were formulated by varying LBG: PVA ratio and evaluated for percentage yield, drug entrapment efficiency (DEE), swelling properties and in vitro drug release studies. Further characterizations were done by Fourier Transform Infrared Spectroscopy (FTIR), C13 Solid state NMR, X-Ray diffraction study (XRD), Scanning electron microscopy (SEM), and Differential scanning microscopy (DSC) studies. Results: The percentage yield, drug entrapment and equilibrium swelling was observed to be dependent on PVA-LBG ratio and GA amount. Sustained release of drug was observed in all IPN formulations (approx 59 - 86% in 8 h in various batches) with variable release kinetics. SEM studies revealed the regular structures of IPNs. FTIR, XRD, C13 Solid state NMR and DSC studies proposed that drug was successfully incorporated into the formed IPNs. Conclusion: IPNs of LBG and PVA can be used as a promising carrier with uniform sustained release characteristics.

Phase separation in the polyurethane/poly(2-hydroxyethyl methacrylate) semi-interpenetrating polymer networks synthesized by different ways

2008 ◽  
Vol 48 (3) ◽  
pp. 588-597 ◽  
Author(s):  
Lyudmyla V. Karabanova ◽  
Gisele Boiteux ◽  
Gerard Seytre ◽  
Isabelle Stevenson ◽  
Andrew W. Lloyd ◽  
...  
Keyword(s):  
Phase Separation ◽  
Polymer Networks ◽  
Interpenetrating Polymer Networks ◽  
Hydroxyethyl Methacrylate

scholarly journals Site-Specific Identification of an Aβ Fibril-Heparin Interaction Site by Using Solid-State NMR Spectroscopy

2012 ◽  
Vol 124 (52) ◽  
pp. 13317-13320
Author(s):  
Jillian Madine ◽  
Maya J. Pandya ◽  
Matthew R. Hicks ◽  
Alison Rodger ◽  
Edwin A. Yates ◽  
...  
Keyword(s):  
Solid State ◽  
Nmr Spectroscopy ◽  
Solid State Nmr ◽  
Site Specific ◽  
Specific Identification ◽  
Interaction Site ◽  
Solid State Nmr Spectroscopy ◽  
Heparin Interaction

Emissive Semi-Interpenetrating Polymer Networks for Ink-Jet Printed Multilayer OLEDs

2021 ◽  
Author(s):  
Susanna V. Kunz ◽  
Cameron M. Cole ◽  
Thomas Baumann ◽  
Prashant Murlidhar Sonar ◽  
Soniya Yambem ◽  
...  
Keyword(s):  
Light Emitting Diodes ◽  
Polymer Networks ◽  
Interpenetrating Polymer Networks ◽  
Organic Light Emitting Diodes ◽  
Cross Linking ◽  
Solution Processing ◽  
Light Emitting ◽  
Polymer Precursors ◽  
Organic Light ◽  
Ink Jet

Solution-processing of multilayered Organic Light Emitting Diodes (OLEDs) remains a challenge that is often addressed by cross-linking polymer precursors into insoluble networks. Herein, we blend an emissive polymer carrying a...

A structural study of silicon-based interpenetrating polymer networks by solid state 1H and 13C NMR spectroscopy

2002 ◽  
Vol 602-603 ◽  
pp. 321-333 ◽  
Author(s):  
Masatoshi Kobayashi ◽  
Shigeki Kuroki ◽  
Isao Ando ◽  
Kazuo Yamauchi ◽  
Hideaki Kimura ◽  
...  
Keyword(s):  
Solid State ◽  
Nmr Spectroscopy ◽  
Structural Study ◽  
13C Nmr ◽  
Polymer Networks ◽  
13C Nmr Spectroscopy ◽  
Interpenetrating Polymer Networks ◽  
1H And 13C Nmr ◽  
Silicon Based
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