Prevention of Protein Adsorption by Tethered Poly(ethylene oxide) Layers:  Experiments and Single-Chain Mean-Field Analysis

Langmuir ◽  
1998 ◽  
Vol 14 (1) ◽  
pp. 176-186 ◽  
Author(s):  
Timothy McPherson ◽  
Argaw Kidane ◽  
Igal Szleifer ◽  
Kinam Park
Keyword(s):  
Ethylene Oxide ◽  
Protein Adsorption ◽  
Mean Field ◽  
Field Analysis ◽  
Single Chain ◽  
Oxide Layers ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Poly(ethylene oxide) Layers Grafted to Dopamine-melanin Anchoring Layer: Stability and Resistance to Protein Adsorption

2011 ◽  
Vol 12 (9) ◽  
pp. 3232-3242 ◽  
Author(s):  
Ognen Pop-Georgievski ◽  
Štěpán Popelka ◽  
Milan Houska ◽  
Dagmar Chvostová ◽  
Vladimír Proks ◽  
...  
Keyword(s):  
Ethylene Oxide ◽  
Protein Adsorption ◽  
Oxide Layers ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Poly(ethylene oxide) Grafted to Silicon Surfaces: Grafting Density and Protein Adsorption

1998 ◽  
Vol 31 (15) ◽  
pp. 5059-5070 ◽  
Author(s):  
Susan J. Sofia ◽  
V. Premnath ◽  
Edward W. Merrill
Keyword(s):  
Ethylene Oxide ◽  
Protein Adsorption ◽  
Silicon Surfaces ◽  
Grafting Density ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

scholarly journals Nonfouling Poly(ethylene oxide) Layers End-Tethered to Polydopamine

Langmuir ◽  
2012 ◽  
Vol 28 (40) ◽  
pp. 14273-14283 ◽  
Author(s):  
Ognen Pop-Georgievski ◽  
Dominique Verreault ◽  
Mark-Oliver Diesner ◽  
Vladimír Proks ◽  
Stefan Heissler ◽  
...  
Keyword(s):  
Ethylene Oxide ◽  
Oxide Layers ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Self-Assembled Monolayers as Models for Studying Protein Adsorption to Polymer Surfaces

1991 ◽  
Vol 237 ◽  
Author(s):  
Kevin L. Prime ◽  
George M. Whttesides
Keyword(s):  
Ethylene Oxide ◽  
Protein Adsorption ◽  
Organic Materials ◽  
Polymer Surfaces ◽  
Self Assembled Monolayers ◽  
Assembled Monolayers ◽  
Poly Ethylene Oxide ◽  
Self Assembled ◽  
Protein Resistant ◽  
Poly Ethylene

ABSTRACTSelf-assembled monolayers (SAMs) of functionalized alkanethiolates on gold are a well-characterized system for studying the interfacial properties of organic materials. We have used SAMs as models for the surfaces of organic polymers and used mem to study the adsorption of proteins onto organic materials. We have formed SAMs from mixtures of alkanethiols in which one alkanethiol is hydrophobic and the other is terminated by a short (2 ≤ n ≤ 17) oligomer of poly(ethylene oxide). These “mixed” SAMs effectively resist the adsorption of fibrinogen from moderately concentrated (1 mg/mL) solutions. Protein adsorption begins when < 5% of the accessible area of the surface consists of hydrophobic groups. These findings suggest that real protein-resistant monolayers must present an almost defect-free surface of oligo(ethylene oxide) groups in order to eliminate adsorption.

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