Surface-Conditioning Effect of Gold Substrates on Octadecanethiol Self-Assembled Monolayer Growth

Langmuir ◽  
1997 ◽  
Vol 13 (17) ◽  
pp. 4638-4643 ◽  
Author(s):  
Takao Ishida ◽  
Satoshi Tsuneda ◽  
Naoki Nishida ◽  
Masahiko Hara ◽  
Hiroyuki Sasabe ◽  
...  
Langmuir ◽  
2005 ◽  
Vol 21 (4) ◽  
pp. 1661-1661 ◽  
Author(s):  
C. O'Dwyer ◽  
G. Gay ◽  
B. Viaris de Lesegno ◽  
J. Weiner

Coatings ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1014
Author(s):  
Zijiao Zhang ◽  
Ni Kou ◽  
Weilong Ye ◽  
Shuo Wang ◽  
Jiaju Lu ◽  
...  

Background: Infection that is related to implanted biomaterials is a serious issue in the clinic. Antimicrobial peptides (AMPs) have been considered as an ideal alternative to traditional antibiotic drugs, for the treatment of infections, while some problems, such as aggregation and protein hydrolysis, are still the dominant concerns that compromise their antimicrobial efficiency in vivo. Methods: In this study, antimicrobial peptides underwent self-assembly on gold substrates, forming good antibacterial surfaces, with stable antibacterial behavior. The antimicrobial ability of AMPs grafted on the surfaces, with or without glycine spaces or a primer layer, was evaluated. Results: Specifically, three Pac-525 derivatives, namely, Ac-CGn-KWRRWVRWI-NH2 (n = 0, 2, or 6) were covalently grafted onto gold substrates via the self-assembling process for inhibiting the growth of Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Furthermore, the alkanethiols HS(CH)10SH were firstly self-assembled into monolayers, as a primer layer (SAM-SH) for the secondary self-assembly of Pac-525 derivatives, to effectively enhance the bactericidal performance of the grafted AMPs. The -(CH)10-S-S-G6Pac derivative was highly effective against S. aureus and E. coli, and reduced the viable amount of E. coli and S. aureus to 0.4% and 33.2%, respectively, after 24 h of contact. In addition, the immobilized AMPs showed good biocompatibility, promoting bone marrow stem cell proliferation. Conclusion: the self-assembled monolayers of the Pac-525 derivatives have great potential as a novel therapeutic method for the treatment of implanted biomaterial infections.


2006 ◽  
Vol 252 (10) ◽  
pp. 3532-3540 ◽  
Author(s):  
S. Pimanpang ◽  
Pei-I. Wang ◽  
G.-C. Wang ◽  
T.-M. Lu

2019 ◽  
Vol 3 (4) ◽  
pp. 636-639 ◽  
Author(s):  
Esther Frederick ◽  
Travis W. Shaw ◽  
Matthew G. Frith ◽  
Steven L. Bernasek

Carbene based self-assembled monolayers are demonstrated to be effective supports for forming highly stable surface-mounted metal–organic frameworks on gold substrates.


Langmuir ◽  
1998 ◽  
Vol 14 (26) ◽  
pp. 7456-7462 ◽  
Author(s):  
Katsuhiko Fujita ◽  
Masahiko Hara ◽  
Hiroyuki Sasabe ◽  
Wolfgang Knoll ◽  
Kazuma Tsuboi ◽  
...  

2004 ◽  
Vol 126 (30) ◽  
pp. 9369-9373 ◽  
Author(s):  
James M. Mellott ◽  
Daniel K. Schwartz

Sign in / Sign up

Export Citation Format

Share Document