In Situ Kinetics of Self-Assembly by Surface Plasmon Resonance Spectroscopy

Langmuir ◽  
1996 ◽  
Vol 12 (20) ◽  
pp. 4731-4740 ◽  
Author(s):  
Kevin A. Peterlinz ◽  
R. Georgiadis
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Self Assembly ◽  
Resonance Spectroscopy ◽  
Surface Plasmon Resonance Spectroscopy ◽  
Kinetics Of

scholarly journals Investigations of Surface Interactions between PEGDA-Polymer and Drug using Surface Plasmon Resonance

2021 ◽  
Vol 7 (2) ◽  
pp. 708-710
Author(s):  
Helge Lange ◽  
Natalia Rekowska ◽  
Katharina Wulf ◽  
Niels Grabow ◽  
Thomas Eickner
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Release Kinetics ◽  
Average Molecular Weight ◽  
Surface Interactions ◽  
Resonance Spectroscopy ◽  
Surface Plasmon Resonance Spectroscopy ◽  
Dexamethasone Phosphate ◽  
Kinetics Of

Abstract For the development of combination products, the determination of the release kinetics of polymer-based drug delivery systems (DDS) is a central and often timeconsuming investigation. Classical methods are often unsuitable for large-scale screening of potential polymers for combination products. We present a rapid method based on surface plasmon resonance spectroscopy (SPR), using PEGDA700 (Poly(ethylene glycol) diacrylate, average molecular weight (Mn) 700) as an example. This method is capable of determinating the kinetics of drug association and subsequent release within minutes. The proportion of desorption and diffusion can be determined separately. Surface plasmon resonance spectroscopy (SPR) is a label-free and very sensitive optical technique, which allows for real-time observation of surface interactions. The prepared SPR chips were spin-coated with PEGDA700 and crosslinked via photoinduced polymerization. The association and dissociation kinetics of dexamethasone phosphate in swollen PEGDA700 have been studied at different concentrations. The maximum loading of the surface was also obtained by this method. The study of PEGDA presented here identified the wellestablished SPR-based spectroscopy as a potential tool in the development of combination products.

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