Oligo(ethylene oxide) Self-Assembled Monolayers with Self-Limiting Packing Densities for the Inhibition of Nonspecific Protein Adsorption

Langmuir ◽  
2009 ◽  
Vol 25 (9) ◽  
pp. 5026-5030 ◽  
Author(s):  
David J. Vanderah ◽  
Ryan J. Vierling ◽  
Marlon L. Walker
Keyword(s):  
Ethylene Oxide ◽  
Protein Adsorption ◽  
Self Assembled Monolayers ◽  
Assembled Monolayers ◽  
Self Assembled ◽  
Nonspecific Protein Adsorption ◽  
Packing Densities

Self-Assembled Monolayers as Models for Studying Protein Adsorption to Polymer Surfaces

1991 ◽  
Vol 237 ◽  
Author(s):  
Kevin L. Prime ◽  
George M. Whttesides
Keyword(s):  
Ethylene Oxide ◽  
Protein Adsorption ◽  
Organic Materials ◽  
Polymer Surfaces ◽  
Self Assembled Monolayers ◽  
Assembled Monolayers ◽  
Poly Ethylene Oxide ◽  
Self Assembled ◽  
Protein Resistant ◽  
Poly Ethylene

ABSTRACTSelf-assembled monolayers (SAMs) of functionalized alkanethiolates on gold are a well-characterized system for studying the interfacial properties of organic materials. We have used SAMs as models for the surfaces of organic polymers and used mem to study the adsorption of proteins onto organic materials. We have formed SAMs from mixtures of alkanethiols in which one alkanethiol is hydrophobic and the other is terminated by a short (2 ≤ n ≤ 17) oligomer of poly(ethylene oxide). These “mixed” SAMs effectively resist the adsorption of fibrinogen from moderately concentrated (1 mg/mL) solutions. Protein adsorption begins when < 5% of the accessible area of the surface consists of hydrophobic groups. These findings suggest that real protein-resistant monolayers must present an almost defect-free surface of oligo(ethylene oxide) groups in order to eliminate adsorption.

Self-Assembled Monolayers of Methyl 1-Thiahexa(ethylene oxide) for the Inhibition of Protein Adsorption

Langmuir ◽  
2002 ◽  
Vol 18 (12) ◽  
pp. 4674-4680 ◽  
Author(s):  
David J. Vanderah ◽  
Gintaras Valincius ◽  
Curtis W. Meuse
Keyword(s):  
Ethylene Oxide ◽  
Protein Adsorption ◽  
Self Assembled Monolayers ◽  
Assembled Monolayers ◽  
Self Assembled

Endothelial Cell Growth and Protein Adsorption on Terminally Functionalized, Self-Assembled Monolayers of Alkanethiolates on Gold

Langmuir ◽  
1997 ◽  
Vol 13 (13) ◽  
pp. 3404-3413 ◽  
Author(s):  
Caren D. Tidwell ◽  
Sylvie I. Ertel ◽  
Buddy D. Ratner ◽  
Barbara J. Tarasevich ◽  
Sundar Atre ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Growth ◽  
Protein Adsorption ◽  
Self Assembled Monolayers ◽  
Assembled Monolayers ◽  
Endothelial Cell Growth ◽  
Self Assembled

Enantiopure Chiral Poly(glycerol methacrylate) Self-Assembled Monolayers Knock Down Protein Adsorption and Cell Adhesion

2013 ◽  
Vol 2 (10) ◽  
pp. 1377-1387 ◽  
Author(s):  
Zheng Li ◽  
Alexander Köwitsch ◽  
Guoying Zhou ◽  
Thomas Groth ◽  
Bodo Fuhrmann ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Protein Adsorption ◽  
Self Assembled Monolayers ◽  
Knock Down ◽  
Assembled Monolayers ◽  
Self Assembled

Molecular dynamics of self-assembled monolayers of functionalized alkanethiols for protein adsorption

2009 ◽  
Author(s):  
B. Szefczyk ◽  
M. N. D. S. Cordeiro ◽  
J. A. N. F. Gomes ◽  
Joaquín Marro ◽  
Pedro L. Garrido ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Protein Adsorption ◽  
Self Assembled Monolayers ◽  
Assembled Monolayers ◽  
Self Assembled

Variation in Tenacity of Protein Adsorption on Self-Assembled Monolayers with Monolayer Order As Observed by X-ray Reflectivity

Langmuir ◽  
1997 ◽  
Vol 13 (7) ◽  
pp. 1881-1883 ◽  
Author(s):  
Stanislaw Petrash ◽  
Nina B. Sheller ◽  
William Dando ◽  
Mark D. Foster
Keyword(s):  
Protein Adsorption ◽  
Self Assembled Monolayers ◽  
X Ray ◽  
Assembled Monolayers ◽  
Self Assembled
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