Human Alveolar Epithelial Cell Responses to Core–Shell Superparamagnetic Iron Oxide Nanoparticles (SPIONs)

Langmuir ◽  
2015 ◽  
Vol 31 (13) ◽  
pp. 3829-3839 ◽  
Author(s):  
Doris Antoinette Mbeh ◽  
Laura Karina Mireles ◽  
Dimitri Stanicki ◽  
Lyes Tabet ◽  
Karim Maghni ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Epithelial Cell ◽  
Iron Oxide Nanoparticles ◽  
Alveolar Epithelial Cell ◽  
Superparamagnetic Iron Oxide ◽  
Oxide Nanoparticles ◽  
Core Shell ◽  
Alveolar Epithelial ◽  
Cell Responses ◽  
Human Alveolar Epithelial Cell

scholarly journals Cyclodextrin-Appended Superparamagnetic Iron Oxide Nanoparticles as Cholesterol-Mopping Agents

2021 ◽  
Vol 9 ◽  
Author(s):  
Antonino Puglisi ◽  
Simone Bassini ◽  
Erik Reimhult
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Cholesterol Metabolism ◽  
Genetic Disorders ◽  
Superparamagnetic Iron Oxide ◽  
Binding Activity ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Core Shell ◽  
Full Characterization

Cholesterol plays a crucial role in major cardiovascular and neurodegenerative diseases, including Alzheimer’s disease and rare genetic disorders showing altered cholesterol metabolism. Cyclodextrins (CDs) have shown promising therapeutic efficacy based on their capacity to sequester and mobilise cholesterol. However, the administration of monomeric CDs suffers from several drawbacks due to their lack of specificity and poor pharmacokinetics. We present core-shell superparamagnetic iron oxide nanoparticles (SPIONs) functionalised with CDs appended to poly (2-methyl-2-oxazoline) polymers grafted in a dense brush to the iron oxide core. The CD-decorated nanoparticles (CySPIONs) are designed so that the macrocycle is specifically cleaved off the nanoparticle’s shell at a slightly acidic pH. In the intended use, free monomeric CDs will then mobilise cholesterol out of the lysosome to the cytosol and beyond through the formation of an inclusion complex. Hence, its suitability as a therapeutic platform to remove cholesterol in the lysosomal compartment. Synthesis and full characterization of the polymer as well as of the core-shell SPION are presented. Cholesterol-binding activity is shown through an enzymatic assay.

Recent developments in the synthesis, properties, and biomedical applications of core/shell superparamagnetic iron oxide nanoparticles with gold

2017 ◽  
Vol 5 (11) ◽  
pp. 2212-2225 ◽  
Author(s):  
Sandip Sabale ◽  
Priyanka Kandesar ◽  
Vidhya Jadhav ◽  
Rachel Komorek ◽  
Radha Kishan Motkuri ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Biomedical Applications ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Core Shell ◽  
Synthesis Properties ◽  
Recent Developments ◽  
Biomedical Field

In the last decade, Gold (Au) coated superparamagnetic iron oxide nanoparticles (SPIONs), have immensely promoted the advancement of diagnostics and theranostics in the biomedical field.

scholarly journals SPION@polydehydroalanine hybrid particles

RSC Advances ◽  
2015 ◽  
Vol 5 (40) ◽  
pp. 31920-31929 ◽  
Author(s):  
Moritz von der Lühe ◽  
Ulrike Günther ◽  
Andreas Weidner ◽  
Christine Gräfe ◽  
Joachim H. Clement ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Hybrid Nanoparticles ◽  
Oxide Nanoparticles ◽  
Core Shell ◽  
Hybrid Particles

We report on the coating of superparamagnetic iron oxide nanoparticles using polyanionic or polyzwitterionic materials based on polydehydroalanine. The resulting core–shell hybrid nanoparticles exhibit shells of different charge and thickness.

TARGETING CYCLIN B1 WITH ANTISENSE OLIGONUCLETOTIDES- COATED SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES

2018 ◽  
Vol 6 (10) ◽  
Author(s):  
Hosam Zaghloul ◽  
Doaa A. Shahin ◽  
Ibrahim El- Dosoky ◽  
Mahmoud E. El-awady ◽  
Fardous F. El-Senduny ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Cellular Uptake ◽  
Superparamagnetic Iron Oxide ◽  
Cyclin B1 ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Mcf7 Cells ◽  
M Phase ◽  
The Impact

Antisense oligonucleotides (ASO) represent an attractive trend as specific targeting molecules but sustain poor cellular uptake meanwhile superparamagnetic iron oxide nanoparticles (SPIONs) offer stability of ASO and improved cellular uptake. In the present work we aimed to functionalize SPIONs with ASO targeting the mRNA of Cyclin B1 which represents a potential cancer target and to explore its anticancer activity. For that purpose, four different SPIONs-ASO conjugates, S-M (1–4), were designated depending on the sequence of ASO and constructed by crosslinking carboxylated SPIONs to amino labeled ASO. The impact of S-M (1–4) on the level of Cyclin B1, cell cycle, ROS and viability of the cells were assessed by flowcytometry. The results showed that S-M3 and S-M4 reduced the level of Cyclin B1 by 35 and 36%, respectively. As a consequence to downregulation of Cyclin B1, MCF7 cells were shown to be arrested at G2/M phase (60.7%). S-M (1–4) led to the induction of ROS formation in comparison to the untreated control cells. Furthermore, S-M (1–4) resulted in an increase in dead cells compared to the untreated cells and SPIONs-treated cells. In conclusion, targeting Cyclin B1 with ASO-coated SPIONs may represent a specific biocompatible anticancer strategy.

Sign in / Sign up

Export Citation Format

Share Document