Thixotropic Hydrogelators Based on a Cyclo(dipeptide) Derivative

Langmuir ◽  
2013 ◽  
Vol 29 (47) ◽  
pp. 14666-14673 ◽  
Author(s):  
Hiroko Hoshizawa ◽  
Yuta Minemura ◽  
Katsunori Yoshikawa ◽  
Masahiro Suzuki ◽  
Kenji Hanabusa
Keyword(s):  
Dipeptide Derivative

scholarly journals Synthesis and Characterizations of Dipeptide Derivative of Gentamicin

2019 ◽  
Vol 28 (2) ◽  
pp. 73-82
Author(s):  
Oun D. Khudair ◽  
Diar A. Fatih
Keyword(s):  
Acid Chloride ◽  
Solution Method ◽  
Hydroxyl Group ◽  
Hydroxyl Groups ◽  
Free Hydroxyl ◽  
Ester Linkage ◽  
Amine Groups ◽  
Conventional Solution ◽  
Dipeptide Derivative

Abstract       The target derivative are gentamicin linked with L-Val- L-Ala by an ester linkage. These were synthesized by esterification method, which included the reaction of -OH hydroxyl group on (carbon No.5) of gentamicin with the acid chloride of the corresponding dipeptide, The preparation of new derivative of gentamicin involved protected the primary & secondary amine groups of Gentamicin, by Ethylchloroformate (ECF) to give N-carbomethoxy Gentamicin which was used for further chemical synthesis involving the free hydroxyl groups. Then prepared dipeptide (L-Val- L-Ala) by conventional solution method in present DCC & HoBt then reacted with thionyl chloride to prepared acid chloride of dipeptides, then after, linked by ester linkage to N-protection gentamicin in present pyridine as base, finally deportation the amino group of synthesized compound by using TFAA in present anisole. The characterization of the titled compounds were performed utilizing FTIR spectroscopy, CHNS elemental analysis, and by measurements of their physical properties.  

scholarly journals Enhancement of platelet recovery in X-irradiated guinea pigs by romurtide, a synthetic muramyl dipeptide derivative

Blood ◽  
1994 ◽  
Vol 83 (9) ◽  
pp. 2480-2488 ◽  
Author(s):  
K Namba ◽  
T Otani ◽  
Y Osada
Keyword(s):  
Guinea Pigs ◽  
Therapeutic Potential ◽  
Muramyl Dipeptide ◽  
Recovery Phase ◽  
Platelet Recovery ◽  
Platelet Counts ◽  
Normal Platelet ◽  
Wbc Count ◽  
Time Required ◽  
Dipeptide Derivative

Abstract The response of megakaryocytes and platelets to the administration of romurtide, a synthetic muramyl dipeptide derivative, was investigated in normal and irradiated guinea pigs. Romurtide was administered subcutaneously in a single dose or daily doses at levels of 1 to 100 micrograms/animal/day to normal animals to assess the dose response. Subsequently, dosage at 100 micrograms/animal/d for 8 consecutive days was initiated in separate groups of animals immediately after 1 Gy total body x-irradiation. In normal animals, a significant dose- dependent increase in the platelet count was noted, and a prolonged thrombocytopoiesis was detectable from 7 through 15 days after the initiation of romurtide administered for 8 days at a dose of 100 micrograms/animal/d. A significant increase in the white blood cell (WBC) count was also observed during days 1 through 11 after beginning romurtide treatment. In the irradiated animals, the treatment with romurtide increased platelet counts during the recovery phase of thrombocytopenia, thus apparently decreasing the time required for recovery to a normal platelet level. Before the rapid recovery of platelet counts by romurtide treatment, a marked increase in the number of megakaryocytes was noted as early as 7 days after irradiation. This increase was accompanied by an accelerated shift of the size distribution of megakaryocytes toward larger size class. Thus, the mean megakaryocyte size was significantly greater in guinea pigs receiving romurtide than in controls. Preceding the increase in the number of megakaryocytes, the serum interleukin-6 levels were found to be approximately 5 times greater than those in control animals. Treatment with romurtide diminished the WBC count nadir, resulting in significantly higher WBC count levels than in controls. Elevation of the plasma fibrinogen level was observed in the treated animals, and normalized gradually after discontinuation of romurtide treatment. These results indicate a possible therapeutic potential of romurtide in the management of thrombocytopenia associated with myelosuppression.

scholarly journals Interplay between polarity and chirality in the electric-field-responsive columnar phase of a dipeptide derivative

2012 ◽  
Vol 4 (4) ◽  
pp. e11-e11 ◽  
Author(s):  
Naomi Koizumi ◽  
Govindaswamy Shanker ◽  
Fumito Araoka ◽  
Ken Ishikawa ◽  
Channabasaveshwar V Yelamaggad ◽  
...  
Keyword(s):  
Electric Field ◽  
Columnar Phase ◽  
Dipeptide Derivative

The Synthesis of a Cubane-Substituted Dipeptide

2012 ◽  
Vol 65 (6) ◽  
pp. 690 ◽  
Author(s):  
Quentin I. Churches ◽  
Roger J. Mulder ◽  
Jonathan M. White ◽  
John Tsanaktsidis ◽  
Peter J. Duggan
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
High Sensitivity ◽  
Pure Form ◽  
Bioactive Molecules ◽  
Side Chains ◽  
Cyclic Hydrocarbon ◽  
Wide Range ◽  
Effective Synthesis ◽  
Dipeptide Derivative

Amino acids and peptides bearing cyclic hydrocarbon side-chains are of interest in the development of a wide range of bioactive molecules. The preparation of an amino acid and a dipeptide derivative bearing an unfunctionalised cubane substituent is described. Attempts to prepare a cubylalanine derivative via the corresponding dehydroalanine were unsuccessful due to the high sensitivity of this vinyl cubane compound. Conversely, the addition of cubyllithium to a (RS)-glyoxylate sulfinimine led to an effective synthesis of a cubylglycine derivative and a cubane-substituted dipeptide in diastereomerically pure form.

Interleukin-1-induced sleep and febrile responses differentially altered by a muramyl dipeptide derivative

1989 ◽  
Vol 11 (8) ◽  
pp. 887-893 ◽  
Author(s):  
Alan B. Cady ◽  
Gilles Riveau ◽  
Louis Chedid ◽  
Charles A. Dinarello ◽  
Lars Johannsen ◽  
...  
Keyword(s):  
Interleukin 1 ◽  
Muramyl Dipeptide ◽  
Dipeptide Derivative

scholarly journals The first supramolecular peptidic hydrogelator containing taurine

2014 ◽  
Vol 50 (21) ◽  
pp. 2772-2774 ◽  
Author(s):  
Yi Kuang ◽  
Yuan Gao ◽  
Junfeng Shi ◽  
Jie Li ◽  
Bing Xu
Keyword(s):  
Amino Acid ◽  
Rich Phase ◽  
Proteinogenic Amino Acid ◽  
A Cell ◽  
Phase Behaviors ◽  
Dipeptide Derivative

The conjugation of taurine, a non-proteinogenic amino acid, with a dipeptide derivative affords a cell compatible, small molecular hydrogelator that self-assembles in water to exhibit rich phase behaviors.

Inhibition of endogenous pyrogen-induced fever by a muramyl dipeptide derivative

1984 ◽  
Vol 247 (3) ◽  
pp. C169-C174 ◽  
Author(s):  
M. Parant ◽  
G. Riveau ◽  
F. Parant ◽  
L. Chedid
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Muramyl Dipeptide ◽  
Central Effect ◽  
Intravenous Route ◽  
Endogenous Pyrogen ◽  
Febrile Response ◽  
Bacterial Peptidoglycan ◽  
Dipeptide Derivative

N-acetylmuramyl-L-alanyl-D-isoglutamine, or muramyl dipeptide (MDP), is a synthetic immunoadjuvant analogue of a bacterial peptidoglycan subunit that has a definite pyrogenic effect in the rabbit. Some adjuvant-active derivatives such as murabutide [MDP(Gln)-OnBu] or murametide [MDP(Gln)-OMe] are not pyrogenic. Murabutide did not stimulate human or rabbit cells to release endogenous pyrogen (EP), but murametide induced EP production at the same dosage levels as MDP. Moreover, plasma from rabbits treated with murametide transferred into untreated recipients elicited a febrile response typical of EP fever and comparable with that induced by plasma from MDP-treated animals. Murametide not only inhibited the central effect of EP that is generated but also the effect of an extra dose of EP administered later by the intravenous route. Moreover, pretreatment of rabbits with murametide decreased fever responses induced by certain high-molecular-weight exogenous pyrogens as mediated through the production of EP.

Use of a gel-forming dipeptide derivative as a carrier for antigen presentation

1995 ◽  
Vol 1 (6) ◽  
pp. 371-378 ◽  
Author(s):  
Rolands Vegners ◽  
Irina Shestakova ◽  
Ivars Kalvinsh ◽  
Robert M. Ezzell ◽  
Paul A. Janmey
Keyword(s):  
Antigen Presentation ◽  
Dipeptide Derivative
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